YLR136C / TIS11

mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR136C / TIS11

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.93|P-value:9.05E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:2.99|P-value:7.24E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.14|P-value:5.35E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:2.99|P-value:7.30E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.07|P-value:5.46E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.25|P-value:3.15E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.02|P-value:6.86E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.96|P-value:6.94E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:4.85|P-value:1.27E-7 ID:SGTC_406|Compound:estrone|FD-Score:3.30|P-value:2.22E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.33|P-value:2.06E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:2.97|P-value:8.02E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.44|P-value:1.30E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.52|P-value:9.19E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.86|P-value:2.04E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.16|P-value:3.89E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.34|P-value:1.99E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.81|P-value:2.50E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.71|P-value:4.25E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.85|P-value:2.13E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.02|P-value:4.78E-8 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.31|P-value:2.34E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.72|P-value:2.75E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.81|P-value:1.66E-7 ID:SGTC_2100|Compound:5377183|FD-Score:3.83|P-value:2.31E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.56|P-value:7.54E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.06|P-value:5.60E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.37|P-value:1.68E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.38|P-value:1.59E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:3.66|P-value:4.95E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.47|P-value:1.14E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.20|P-value:3.90E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.87|P-value:1.91E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-2.98|P-value:8.05E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.12|P-value:4.65E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.42|P-value:1.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:2.99|P-value:7.22E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.98|P-value:1.18E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-6.97|P-value:7.02E-14 ID:SGTC_3207|Compound:9114163|FD-Score:5.26|P-value:1.14E-8 ID:SGTC_3221|Compound:9128209|FD-Score:3.02|P-value:6.68E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.66|P-value:4.99E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:2.93|P-value:9.05E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:2.99|P-value:7.24E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.14|P-value:5.35E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:2.99|P-value:7.30E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.07|P-value:5.46E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.25|P-value:3.15E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.02|P-value:6.86E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.96|P-value:6.94E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:4.85|P-value:1.27E-7 ID:SGTC_406|Compound:estrone|FD-Score:3.30|P-value:2.22E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.33|P-value:2.06E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:2.97|P-value:8.02E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.44|P-value:1.30E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.52|P-value:9.19E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.86|P-value:2.04E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.16|P-value:3.89E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.34|P-value:1.99E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.81|P-value:2.50E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.71|P-value:4.25E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.85|P-value:2.13E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.02|P-value:4.78E-8 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.31|P-value:2.34E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.72|P-value:2.75E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.81|P-value:1.66E-7 ID:SGTC_2100|Compound:5377183|FD-Score:3.83|P-value:2.31E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.56|P-value:7.54E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.06|P-value:5.60E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.37|P-value:1.68E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.38|P-value:1.59E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:3.66|P-value:4.95E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:3.47|P-value:1.14E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.20|P-value:3.90E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.87|P-value:1.91E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-2.98|P-value:8.05E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.12|P-value:4.65E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.42|P-value:1.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:2.99|P-value:7.22E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.98|P-value:1.18E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-6.97|P-value:7.02E-14 ID:SGTC_3207|Compound:9114163|FD-Score:5.26|P-value:1.14E-8 ID:SGTC_3221|Compound:9128209|FD-Score:3.02|P-value:6.68E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.66|P-value:4.99E-5

Top fitness defect scores for YLR136C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3207 9114163 5.26 49.5 µM 1.14E-8 10 7.26E-8
2 SGTC_1370 2001-0092 5.02 44.6 µM 4.78E-8 12 2.60E-7
3 SGTC_374 0880-0231 4.85 82.3 µM 1.27E-7 iron homeostasis 9 6.19E-7
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.38 3.7 µM 1.59E-6 57 5.86E-6
5 SGTC_431 k089-0097 4.33 107.0 µM 2.06E-6 iron homeostasis 26 7.41E-6
6 SGTC_1453 4237-0541 4.31 195.0 µM 2.34E-6 heme biosynthesis & mitochondrial translocase 20 8.29E-6
7 SGTC_288 1315-0019 4.25 35.1 µM 3.15E-6 RSC & ERG11 16 1.08E-5
8 SGTC_2546 rhodinyl acetate 4.20 100.0 µM 3.90E-6 9 1.31E-5
9 SGTC_51 1013-0126 4.14 23.4 µM 5.35E-6 26 1.73E-5
10 SGTC_3143 9086658 3.98 49.5 µM 1.18E-5 43 3.49E-5
11 SGTC_2621 lithochol-11-enic acid 3.87 100.0 µM 1.91E-5 26 5.38E-5
12 SGTC_757 1066-0008 3.86 322.0 µM 2.04E-5 Golgi 21 5.71E-5
13 SGTC_1262 0737-0114 3.85 49.6 µM 2.13E-5 21 5.93E-5
14 SGTC_2100 5377183 3.83 190.0 µM 2.31E-5 60S ribosome export 12 6.38E-5
15 SGTC_1084 voriconazole 3.81 435.0 nM 2.50E-5 azole & statin 30 6.84E-5
16 SGTC_2513 baicalein 3.66 25.6 µM 4.95E-5 calcium & mitochondrial duress 34 1.26E-4
17 SGTC_3308 9128332 3.66 17.6 µM 4.99E-5 plasma membrane duress 90 1.27E-4
18 SGTC_2164 5685496 3.56 200.0 µM 7.54E-5 30 1.83E-4
19 SGTC_724 3910-0327 3.52 137.0 µM 9.19E-5 ERG2 30 2.18E-4
20 SGTC_2516 gossypol 3.47 71.5 µM 1.14E-4 28 2.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.88E-45 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.240 2.97E-45 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.208 3.87E-34 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.208 5.00E-34 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.204 8.56E-33 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.197 1.51E-30 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.193 1.42E-29 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.193 2.09E-29 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.182 2.57E-26 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.182 3.89E-26 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.182 2.89E-26 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.180 9.97E-26 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.177 5.49E-25 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.176 7.98E-25 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.166 3.55E-22 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p