YLR140W_d

Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR140W / YLR140W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.57|P-value:2.68E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.46|P-value:1.06E-16 ID:SGTC_70|Compound:0141-0289|FD-Score:3.73|P-value:1.45E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.79|P-value:1.13E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:5.62|P-value:2.41E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:4.07|P-value:3.85E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:-3.95|P-value:6.09E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.48|P-value:3.63E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.37|P-value:5.40E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.29|P-value:7.03E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.88|P-value:1.08E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.90|P-value:7.77E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.23|P-value:8.55E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.66|P-value:1.83E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.40|P-value:4.85E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.32|P-value:6.10E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.16|P-value:2.69E-5 ID:SGTC_1862|Compound:st057513|FD-Score:-4.18|P-value:2.32E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-4.76|P-value:1.80E-6 ID:SGTC_1906|Compound:st060206|FD-Score:3.55|P-value:2.88E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-4.09|P-value:3.44E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:7.52E-5 ID:SGTC_2026|Compound:5148700|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.42|P-value:4.58E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.49|P-value:3.51E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.54|P-value:2.86E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-4.00|P-value:4.93E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-4.72|P-value:2.19E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.27|P-value:7.63E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.41|P-value:4.55E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.27|P-value:7.66E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-5.14|P-value:2.82E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.08|P-value:3.68E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.60|P-value:4.05E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.21|P-value:9.30E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.36|P-value:5.60E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.91|P-value:7.27E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.42|P-value:8.84E-6 ID:SGTC_2821|Compound:7996764|FD-Score:7.21|P-value:1.24E-12 ID:SGTC_2825|Compound:7998094|FD-Score:-6.21|P-value:7.74E-10 ID:SGTC_2832|Compound:7992762|FD-Score:-3.49|P-value:3.44E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.60|P-value:2.27E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.44|P-value:4.26E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.37|P-value:5.29E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.62|P-value:2.10E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.37|P-value:5.44E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.48|P-value:3.59E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.77|P-value:1.20E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.57|P-value:2.68E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.46|P-value:1.06E-16 ID:SGTC_70|Compound:0141-0289|FD-Score:3.73|P-value:1.45E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.79|P-value:1.13E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:5.62|P-value:2.41E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:4.07|P-value:3.85E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:-3.95|P-value:6.09E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.48|P-value:3.63E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.37|P-value:5.40E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.29|P-value:7.03E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.88|P-value:1.08E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.90|P-value:7.77E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.23|P-value:8.55E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.66|P-value:1.83E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.40|P-value:4.85E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.32|P-value:6.10E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.16|P-value:2.69E-5 ID:SGTC_1862|Compound:st057513|FD-Score:-4.18|P-value:2.32E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-4.76|P-value:1.80E-6 ID:SGTC_1906|Compound:st060206|FD-Score:3.55|P-value:2.88E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-4.09|P-value:3.44E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:7.52E-5 ID:SGTC_2026|Compound:5148700|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.42|P-value:4.58E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.49|P-value:3.51E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.54|P-value:2.86E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-4.00|P-value:4.93E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-4.72|P-value:2.19E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.27|P-value:7.63E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.41|P-value:4.55E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.27|P-value:7.66E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-5.14|P-value:2.82E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.08|P-value:3.68E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.60|P-value:4.05E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.21|P-value:9.30E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.36|P-value:5.60E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.91|P-value:7.27E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.42|P-value:8.84E-6 ID:SGTC_2821|Compound:7996764|FD-Score:7.21|P-value:1.24E-12 ID:SGTC_2825|Compound:7998094|FD-Score:-6.21|P-value:7.74E-10 ID:SGTC_2832|Compound:7992762|FD-Score:-3.49|P-value:3.44E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.60|P-value:2.27E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.44|P-value:4.26E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.37|P-value:5.29E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.62|P-value:2.10E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.37|P-value:5.44E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.48|P-value:3.59E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.77|P-value:1.20E-4

Top fitness defect scores for YLR140W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_63 0099-0242 8.46 26.7 µM 1.06E-16 mitochondrial stress 5 1.38E-17 0.02
2 SGTC_2821 7996764 7.21 71.4 µM 1.24E-12 1 2.78E-13 1.12
3 SGTC_123 0083-0120 5.62 66.7 µM 2.41E-8 4 9.56E-9 0.04
4 SGTC_372 0155-0182 4.88 15.9 µM 1.08E-6 mitochondrial response to ROS 5 5.32E-7 0.95
5 SGTC_2600 tangeritin 4.60 88.0 µM 4.05E-6 1 2.15E-6 0.44
6 SGTC_2816 7982706 4.42 58.4 µM 8.84E-6 azole & statin 5 4.91E-6 0.20
7 SGTC_1788 fluconazole 4.16 20.0 µM 2.69E-5 azole & statin 7 1.59E-5 0.26
8 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.08 100.0 µM 3.68E-5 8 2.22E-5 0.30
9 SGTC_156 3474-0145 4.07 5.6 µM 3.85E-5 endomembrane recycling 4 2.33E-5 0.12
10 SGTC_2766 oltipraz 3.91 83.9 µM 7.27E-5 heme requiring 21 4.55E-5 0.07
11 SGTC_1930 st074634 3.90 34.3 µM 7.52E-5 RNA pol III & RNase P/MRP 14 4.71E-5 0.00
12 SGTC_479 n-linoleoylglycine 3.90 10.0 µM 7.77E-5 1 4.88E-5 0.53
13 SGTC_775 4577-0580 3.88 57.3 µM 8.39E-5 4 5.30E-5 0.10
14 SGTC_70 0141-0289 3.73 43.3 µM 1.45E-4 mitochondrial stress 21 9.46E-5 0.03
15 SGTC_2287 7945887 3.73 168.8 µM 1.46E-4 2 9.49E-5 0.22
16 SGTC_35 0133-0054 3.57 64.1 µM 2.68E-4 15 1.81E-4 0.05
17 SGTC_1906 st060206 3.55 94.7 µM 2.88E-4 4 1.95E-4 0.23
18 SGTC_2026 5148700 3.52 152.0 µM 3.19E-4 8 2.17E-4 0.08
19 SGTC_2103 5378138 3.49 10.0 µM 3.51E-4 3 2.40E-4 0.07
20 SGTC_3181 9108277 3.48 49.5 µM 3.59E-4 iron homeostasis 18 2.46E-4 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.54E-14 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.120 2.79E-12 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.117 8.77E-12 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.109 2.81E-10 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.108 3.78E-10 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.107 6.18E-10 YJL181W_p YJL181W_p hom Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication
0.104 1.35E-9 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.103 2.23E-9 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.101 4.93E-9 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.095 3.04E-8 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.01E-8 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.092 9.07E-8 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.091 1.14E-7 YGL129C RSM23 hom Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
0.090 1.63E-7 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
0.090 2.01E-7 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p