YLR141W / RRN5

Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR141W / RRN5

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:-2.98|P-value:8.78E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:2.91|P-value:6.74E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.83|P-value:1.39E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.55|P-value:9.01E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.88|P-value:7.70E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.20|P-value:2.16E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.06|P-value:6.42E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.28|P-value:2.78E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.93|P-value:1.63E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:2.95|P-value:5.77E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.51|P-value:5.97E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.99|P-value:5.02E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.77|P-value:1.84E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.12|P-value:5.30E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.47|P-value:1.10E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.02|P-value:4.50E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.86|P-value:8.30E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-3.64|P-value:6.13E-5 ID:SGTC_1889|Compound:st059080|FD-Score:4.14|P-value:2.96E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.11|P-value:5.41E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.23|P-value:3.40E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.47|P-value:7.12E-5 ID:SGTC_1931|Compound:st074438|FD-Score:-3.70|P-value:4.81E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.71|P-value:2.43E-5 ID:SGTC_2019|Compound:4016004|FD-Score:4.67|P-value:1.70E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:5.67|P-value:3.50E-10 ID:SGTC_2060|Compound:5238662|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.39|P-value:9.99E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.06|P-value:3.85E-4 ID:SGTC_2281|Compound:7943571|FD-Score:4.84|P-value:6.43E-8 ID:SGTC_2303|Compound:7774051|FD-Score:3.66|P-value:3.00E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.07|P-value:3.62E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.40|P-value:9.77E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.52|P-value:5.66E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.63|P-value:3.53E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.04|P-value:4.08E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:2.88|P-value:7.49E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.95|P-value:1.54E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.04|P-value:7.09E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.67|P-value:6.54E-13 ID:SGTC_2821|Compound:7996764|FD-Score:3.16|P-value:2.62E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.11|P-value:1.28E-8 ID:SGTC_2825|Compound:7998094|FD-Score:4.66|P-value:1.84E-7 ID:SGTC_2963|Compound:9082507|FD-Score:3.39|P-value:1.00E-4 ID:SGTC_3007|Compound:9078383|FD-Score:2.83|P-value:8.97E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.10|P-value:5.54E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-4.17|P-value:5.26E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.85|P-value:2.42E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.15|P-value:2.85E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:-2.98|P-value:8.78E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:2.91|P-value:6.74E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.83|P-value:1.39E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.55|P-value:9.01E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.88|P-value:7.70E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.20|P-value:2.16E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.06|P-value:6.42E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.28|P-value:2.78E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.93|P-value:1.63E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:2.95|P-value:5.77E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.51|P-value:5.97E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.99|P-value:5.02E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.77|P-value:1.84E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.12|P-value:5.30E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.47|P-value:1.10E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.02|P-value:4.50E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.86|P-value:8.30E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-3.64|P-value:6.13E-5 ID:SGTC_1889|Compound:st059080|FD-Score:4.14|P-value:2.96E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.11|P-value:5.41E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.23|P-value:3.40E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.47|P-value:7.12E-5 ID:SGTC_1931|Compound:st074438|FD-Score:-3.70|P-value:4.81E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.71|P-value:2.43E-5 ID:SGTC_2019|Compound:4016004|FD-Score:4.67|P-value:1.70E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:5.67|P-value:3.50E-10 ID:SGTC_2060|Compound:5238662|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.39|P-value:9.99E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.06|P-value:3.85E-4 ID:SGTC_2281|Compound:7943571|FD-Score:4.84|P-value:6.43E-8 ID:SGTC_2303|Compound:7774051|FD-Score:3.66|P-value:3.00E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.07|P-value:3.62E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.40|P-value:9.77E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.52|P-value:5.66E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.63|P-value:3.53E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.04|P-value:4.08E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:2.88|P-value:7.49E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.95|P-value:1.54E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.04|P-value:7.09E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.67|P-value:6.54E-13 ID:SGTC_2821|Compound:7996764|FD-Score:3.16|P-value:2.62E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.11|P-value:1.28E-8 ID:SGTC_2825|Compound:7998094|FD-Score:4.66|P-value:1.84E-7 ID:SGTC_2963|Compound:9082507|FD-Score:3.39|P-value:1.00E-4 ID:SGTC_3007|Compound:9078383|FD-Score:2.83|P-value:8.97E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.10|P-value:5.54E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-4.17|P-value:5.26E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.85|P-value:2.42E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.15|P-value:2.85E-6

Top fitness defect scores for YLR141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2042 p-Dimethylaminoacetophenone 5.67 200.0 µM 3.50E-10 2 7.31E-9 1.25
2 SGTC_2823 7987624 5.11 58.4 µM 1.28E-8 7 1.60E-7 0.72
3 SGTC_2281 7943571 4.84 200.0 µM 6.43E-8 3 6.41E-7 1.06
4 SGTC_2019 4016004 4.67 108.0 µM 1.70E-7 7 1.48E-6 0.39
5 SGTC_2825 7998094 4.66 58.4 µM 1.84E-7 fatty acid desaturase (OLE1) 8 1.58E-6 0.11
6 SGTC_520 3584-0023 4.20 682.0 µM 2.16E-6 10 1.31E-5 0.03
7 SGTC_3185 9108267 4.15 49.5 µM 2.85E-6 60S ribosome export 4 1.66E-5 0.15
8 SGTC_1889 st059080 4.14 5.2 µM 2.96E-6 3 1.71E-5 0.12
9 SGTC_182 3448-4371 3.83 550.5 µM 1.39E-5 3 6.44E-5 0.44
10 SGTC_1167 k781-0610 3.77 148.0 µM 1.84E-5 RNA processing & uracil transport 8 8.21E-5 0.07
11 SGTC_2016 5121758 3.71 140.0 µM 2.43E-5 redox potentiating 21 1.04E-4 0.01
12 SGTC_2303 7774051 3.66 200.0 µM 3.00E-5 8 1.25E-4 9.68E-4
13 SGTC_2535 4',4'-dimethoxydalbergione 3.63 51.2 µM 3.53E-5 DNA damage response 3 1.43E-4 0.23
14 SGTC_2448 5185112 3.52 27.2 µM 5.66E-5 8 2.15E-4 0.04
15 SGTC_1030 k029-0042 3.51 36.7 µM 5.97E-5 TSC3-RPN4 8 2.25E-4 0.15
16 SGTC_1930 st074634 3.47 34.3 µM 7.12E-5 RNA pol III & RNase P/MRP 23 2.61E-4 0.20
17 SGTC_2395 5646831 3.40 180.2 µM 9.77E-5 5 3.43E-4 0.06
18 SGTC_2259 7964009 3.39 200.0 µM 9.99E-5 superoxide 8 3.50E-4 0.06
19 SGTC_2963 9082507 3.39 9.0 µM 1.00E-4 14 3.51E-4 0.08
20 SGTC_359 0081-0058 3.35 15.9 µM 1.18E-4 60S ribosome export 24 4.04E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 7.92E-17 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.126 2.62E-13 YKR074W AIM29 hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
0.120 2.81E-12 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.112 9.23E-11 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.103 2.08E-9 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.100 5.85E-9 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.090 1.88E-7 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.089 2.16E-7 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.083 1.64E-6 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.083 1.68E-6 YLR285C-A_p YLR285C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.082 1.75E-6 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.13E-6 YNL316C PHA2 hom Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
0.080 3.31E-6 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.079 4.73E-6 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.078 5.59E-6 YLR236C_d YLR236C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data