YLR145W / RMP1

Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR145W / RMP1

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:3.38|P-value:2.21E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.98|P-value:1.17E-7 ID:SGTC_394|Compound:menadione|FD-Score:3.03|P-value:7.98E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.73|P-value:5.73E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-4.14|P-value:9.10E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:3.67|P-value:6.67E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:5.29|P-value:1.98E-8 ID:SGTC_635|Compound:k038-0028|FD-Score:-3.39|P-value:2.31E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.43|P-value:1.83E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.79|P-value:4.14E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.08|P-value:7.32E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.26|P-value:3.51E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.31|P-value:3.13E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.11|P-value:6.59E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.77|P-value:4.89E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.08|P-value:6.76E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.02|P-value:8.28E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.71|P-value:5.04E-7 ID:SGTC_2058|Compound:5236698|FD-Score:2.97|P-value:9.88E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.23|P-value:3.86E-4 ID:SGTC_2272|Compound:7805186|FD-Score:5.01|P-value:9.42E-8 ID:SGTC_2276|Compound:7947513|FD-Score:3.95|P-value:2.03E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.79|P-value:4.06E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.38|P-value:2.18E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.84|P-value:3.25E-5 ID:SGTC_2476|Compound:5806916|FD-Score:-3.07|P-value:7.46E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.90|P-value:2.72E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.01|P-value:8.75E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.80|P-value:3.92E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.03|P-value:8.73E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.23|P-value:5.50E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.08|P-value:6.79E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-3.41|P-value:2.10E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.03|P-value:7.98E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.46|P-value:1.76E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:3.38|P-value:2.21E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.98|P-value:1.17E-7 ID:SGTC_394|Compound:menadione|FD-Score:3.03|P-value:7.98E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.73|P-value:5.73E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-4.14|P-value:9.10E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:3.67|P-value:6.67E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:5.29|P-value:1.98E-8 ID:SGTC_635|Compound:k038-0028|FD-Score:-3.39|P-value:2.31E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.43|P-value:1.83E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.79|P-value:4.14E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.08|P-value:7.32E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.26|P-value:3.51E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.31|P-value:3.13E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.11|P-value:6.59E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.77|P-value:4.89E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.08|P-value:6.76E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.02|P-value:8.28E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.71|P-value:5.04E-7 ID:SGTC_2058|Compound:5236698|FD-Score:2.97|P-value:9.88E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.23|P-value:3.86E-4 ID:SGTC_2272|Compound:7805186|FD-Score:5.01|P-value:9.42E-8 ID:SGTC_2276|Compound:7947513|FD-Score:3.95|P-value:2.03E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.79|P-value:4.06E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.38|P-value:2.18E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.84|P-value:3.25E-5 ID:SGTC_2476|Compound:5806916|FD-Score:-3.07|P-value:7.46E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.90|P-value:2.72E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.01|P-value:8.75E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.80|P-value:3.92E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.03|P-value:8.73E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.23|P-value:5.50E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.08|P-value:6.79E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-3.41|P-value:2.10E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.03|P-value:7.98E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.46|P-value:1.76E-6

Top fitness defect scores for YLR145W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_634 1611-4317 5.29 11.2 µM 1.98E-8 ERG2 2 6.23E-8 0.46
2 SGTC_2272 7805186 5.01 180.0 µM 9.42E-8 cell wall signaling 2 2.66E-7 1.27
3 SGTC_387 norethindrone acetate 4.98 66.7 µM 1.17E-7 2 3.25E-7 0.74
4 SGTC_1896 st058441 4.71 89.0 µM 5.04E-7 3 1.27E-6 0.10
5 SGTC_3280 9140961 4.46 49.5 µM 1.76E-6 60S ribosome export 4 4.06E-6 0.09
6 SGTC_2939 9044578 4.23 71.4 µM 5.50E-6 4 1.17E-5 0.21
7 SGTC_2276 7947513 3.95 42.1 µM 2.03E-5 4 3.95E-5 0.02
8 SGTC_2381 9035592 3.84 200.0 µM 3.25E-5 8 6.12E-5 0.32
9 SGTC_2842 9000675 3.80 19.5 µM 3.92E-5 10 7.29E-5 0.37
10 SGTC_2343 7990716 3.79 14.8 µM 4.06E-5 4 7.52E-5 0.04
11 SGTC_781 4335-2806 3.79 94.4 µM 4.14E-5 6 7.67E-5 0.03
12 SGTC_627 1391-0720 3.67 175.0 µM 6.67E-5 4 1.20E-4 0.01
13 SGTC_779 1360-0071 3.43 233.0 µM 1.83E-4 fatty acid desaturase (OLE1) 7 3.06E-4 0.01
14 SGTC_2367 9070478 3.38 135.4 µM 2.18E-4 cell wall 16 3.61E-4 0.03
15 SGTC_113 0099-0221 3.38 2.5 µM 2.21E-4 7 3.65E-4 0.22
16 SGTC_823 0417-1665 3.26 178.0 µM 3.51E-4 8 5.61E-4 0.02
17 SGTC_2159 5658611 3.23 73.8 µM 3.86E-4 13 6.13E-4 0.05
18 SGTC_1144 3486-0183 3.08 12.5 µM 6.76E-4 15 0.00103 0.04
19 SGTC_3088 9117578 3.08 49.5 µM 6.79E-4 amide catabolism 11 0.00104 0.10
20 SGTC_394 menadione 3.03 8.3 µM 7.98E-4 superoxide 15 0.00121 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.64E-9 YAL022C FUN26 hom Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
0.092 9.73E-8 YJR068W RFC2 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.084 1.06E-6 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.079 4.40E-6 YBR074W_p YBR074W_p hom Putative metalloprotease
0.078 5.77E-6 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
0.077 8.87E-6 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.076 9.95E-6 YBL069W AST1 hom Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication
0.075 1.54E-5 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
0.074 1.85E-5 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.074 1.97E-5 YER129W SAK1 hom Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
0.073 2.28E-5 YLR409C UTP21 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
0.072 3.26E-5 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.070 5.26E-5 YAL055W PEX22 hom Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
0.069 5.67E-5 YDL088C ASM4 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
0.068 7.51E-5 YGR153W_p YGR153W_p hom Putative protein of unknown function