YLR147C / SMD3

Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR147C / SMD3

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.96|P-value:4.91E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:6.97|P-value:4.59E-12 ID:SGTC_93|Compound:0109-0045|FD-Score:-3.59|P-value:2.79E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.17|P-value:8.82E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.21|P-value:7.71E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.37|P-value:8.73E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.44|P-value:9.34E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.66|P-value:2.17E-4 ID:SGTC_476|Compound:mead acid|FD-Score:4.52|P-value:4.50E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:4.32|P-value:1.11E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.33|P-value:7.01E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.69|P-value:1.97E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.24|P-value:7.03E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.06|P-value:3.30E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:3.56|P-value:2.31E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.24|P-value:9.20E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.48|P-value:8.01E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.26|P-value:8.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.80|P-value:9.33E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_2225|Compound:6654152|FD-Score:5.27|P-value:1.18E-7 ID:SGTC_2261|Compound:9010538|FD-Score:3.18|P-value:8.54E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.33|P-value:5.26E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.42|P-value:7.15E-6 ID:SGTC_2344|Compound:7990960|FD-Score:7.28|P-value:5.35E-13 ID:SGTC_2374|Compound:9071832|FD-Score:3.20|P-value:8.14E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.38|P-value:5.79E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.04|P-value:3.64E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.09|P-value:2.93E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.31|P-value:5.49E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.41|P-value:5.26E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.49|P-value:5.34E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.44|P-value:4.75E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.43|P-value:3.64E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.99|P-value:4.47E-5 ID:SGTC_2934|Compound:9036370|FD-Score:4.01|P-value:4.06E-5 ID:SGTC_2953|Compound:9074162|FD-Score:4.86|P-value:9.51E-7 ID:SGTC_2969|Compound:9091408|FD-Score:4.60|P-value:3.12E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.28|P-value:6.23E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.15|P-value:3.24E-5 ID:SGTC_3201|Compound:9113999|FD-Score:5.09|P-value:3.01E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-4.09|P-value:4.20E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.25|P-value:1.49E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.96|P-value:4.91E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:6.97|P-value:4.59E-12 ID:SGTC_93|Compound:0109-0045|FD-Score:-3.59|P-value:2.79E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.17|P-value:8.82E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.21|P-value:7.71E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.37|P-value:8.73E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.44|P-value:9.34E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.66|P-value:2.17E-4 ID:SGTC_476|Compound:mead acid|FD-Score:4.52|P-value:4.50E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:4.32|P-value:1.11E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.33|P-value:7.01E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.69|P-value:1.97E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.24|P-value:7.03E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.06|P-value:3.30E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:3.56|P-value:2.31E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.24|P-value:9.20E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.48|P-value:8.01E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.26|P-value:8.80E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.80|P-value:9.33E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_2225|Compound:6654152|FD-Score:5.27|P-value:1.18E-7 ID:SGTC_2261|Compound:9010538|FD-Score:3.18|P-value:8.54E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.33|P-value:5.26E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.42|P-value:7.15E-6 ID:SGTC_2344|Compound:7990960|FD-Score:7.28|P-value:5.35E-13 ID:SGTC_2374|Compound:9071832|FD-Score:3.20|P-value:8.14E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.38|P-value:5.79E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.04|P-value:3.64E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.09|P-value:2.93E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.31|P-value:5.49E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.41|P-value:5.26E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.49|P-value:5.34E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-3.44|P-value:4.75E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.43|P-value:3.64E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.99|P-value:4.47E-5 ID:SGTC_2934|Compound:9036370|FD-Score:4.01|P-value:4.06E-5 ID:SGTC_2953|Compound:9074162|FD-Score:4.86|P-value:9.51E-7 ID:SGTC_2969|Compound:9091408|FD-Score:4.60|P-value:3.12E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.28|P-value:6.23E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.15|P-value:3.24E-5 ID:SGTC_3201|Compound:9113999|FD-Score:5.09|P-value:3.01E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-4.09|P-value:4.20E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.25|P-value:1.49E-5

Top fitness defect scores for YLR147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2344 7990960 7.28 77.0 µM 5.35E-13 13 1.67E-13 0.05
2 SGTC_81 0411-0046 6.97 10.0 µM 4.59E-12 16 1.60E-12 0.29
3 SGTC_2225 6654152 5.27 15.4 µM 1.18E-7 18 6.77E-8 0.22
4 SGTC_3201 9113999 5.09 49.5 µM 3.01E-7 3 1.80E-7 0.44
5 SGTC_2953 9074162 4.86 66.5 µM 9.51E-7 2 6.00E-7 0.25
6 SGTC_2969 9091408 4.60 28.7 µM 3.12E-6 3 2.08E-6 0.56
7 SGTC_476 mead acid 4.52 10.0 µM 4.50E-6 1 3.05E-6 0.87
8 SGTC_2797 7859098 4.49 81.8 µM 5.34E-6 7 3.64E-6 0.05
9 SGTC_2327 6189656 4.42 200.0 µM 7.15E-6 5 4.95E-6 0.09
10 SGTC_317 4495-0002 4.37 170.0 µM 8.73E-6 2 6.09E-6 0.36
11 SGTC_669 0108-0021 4.32 26.2 µM 1.11E-5 fatty acid desaturase (OLE1) 11 7.84E-6 0.23
12 SGTC_3306 9127676 4.25 59.8 µM 1.49E-5 3 1.07E-5 0.94
13 SGTC_2526 patulin 4.09 37.6 µM 2.93E-5 11 2.16E-5 0.02
14 SGTC_1854 st056233 4.06 32.9 µM 3.30E-5 amide catabolism 1 2.45E-5 0.18
15 SGTC_2492 derrusnin 4.04 100.0 µM 3.64E-5 5 2.71E-5 0.53
16 SGTC_2934 9036370 4.01 36.9 µM 4.06E-5 5 3.04E-5 0.20
17 SGTC_2894 9048625 3.99 32.5 µM 4.47E-5 8 3.36E-5 0.05
18 SGTC_35 0133-0054 3.96 64.1 µM 4.91E-5 7 3.70E-5 0.06
19 SGTC_2097 5376186 3.80 200.0 µM 9.33E-5 4 7.25E-5 0.40
20 SGTC_2162 5663267 3.77 200.0 µM 1.04E-4 12 8.12E-5 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 7.36E-31 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.118 6.33E-12 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.110 1.76E-10 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene
0.108 3.55E-10 YGR009C SEC9 het t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
0.094 5.94E-8 YDR361C BCP1 het Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
0.093 7.04E-8 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.092 8.47E-8 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.087 4.37E-7 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.087 4.52E-7 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.087 5.26E-7 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.086 5.43E-7 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.086 5.99E-7 YML004C GLO1 hom Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
0.085 7.36E-7 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.085 8.16E-7 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.083 1.50E-6 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm