YLR151C / PCD1

Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR151C / PCD1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.05|P-value:9.24E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:5.30|P-value:3.48E-8 ID:SGTC_89|Compound:0302-0250|FD-Score:3.72|P-value:7.73E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:5.07|P-value:1.27E-7 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.28|P-value:3.97E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.22|P-value:5.23E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.18|P-value:5.70E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-4.07|P-value:1.65E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:5.03|P-value:1.58E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:3.85|P-value:4.57E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:4.49|P-value:2.45E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:3.69|P-value:8.88E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.15|P-value:6.36E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.56|P-value:1.40E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.75|P-value:6.77E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.10|P-value:1.52E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.34|P-value:3.42E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.51|P-value:9.67E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.40|P-value:2.61E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.62|P-value:1.10E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.03|P-value:2.06E-5 ID:SGTC_1627|Compound:st003713|FD-Score:-3.79|P-value:5.41E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.02|P-value:2.22E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.86|P-value:4.04E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.49|P-value:1.81E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.08|P-value:8.34E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.98|P-value:2.57E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.04|P-value:9.64E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.12|P-value:7.49E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.51|P-value:1.79E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.19|P-value:6.00E-4 ID:SGTC_2165|Compound:5727197|FD-Score:6.25|P-value:9.85E-11 ID:SGTC_2348|Compound:9022543|FD-Score:-3.89|P-value:3.56E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-3.79|P-value:5.52E-5 ID:SGTC_2350|Compound:9023895|FD-Score:5.33|P-value:2.93E-8 ID:SGTC_2363|Compound:9053361|FD-Score:3.17|P-value:6.47E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.46|P-value:2.59E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.56|P-value:1.76E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.66|P-value:9.22E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.33|P-value:3.39E-4 ID:SGTC_2625|Compound:euphol|FD-Score:6.73|P-value:3.82E-12 ID:SGTC_2781|Compound:5567276|FD-Score:-3.56|P-value:1.40E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.20|P-value:5.41E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.69|P-value:8.15E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.57|P-value:1.41E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.15|P-value:6.37E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.44|P-value:2.35E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.31|P-value:5.75E-6 ID:SGTC_2927|Compound:9011802|FD-Score:-3.33|P-value:3.31E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.77|P-value:6.31E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.38|P-value:3.00E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.12|P-value:7.26E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.47|P-value:2.00E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.58|P-value:1.37E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.05|P-value:9.24E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:5.30|P-value:3.48E-8 ID:SGTC_89|Compound:0302-0250|FD-Score:3.72|P-value:7.73E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:5.07|P-value:1.27E-7 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.28|P-value:3.97E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.22|P-value:5.23E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.18|P-value:5.70E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-4.07|P-value:1.65E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:5.03|P-value:1.58E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:3.85|P-value:4.57E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:4.49|P-value:2.45E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:3.69|P-value:8.88E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.15|P-value:6.36E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.56|P-value:1.40E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.75|P-value:6.77E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.10|P-value:1.52E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.34|P-value:3.42E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.51|P-value:9.67E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.40|P-value:2.61E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.62|P-value:1.10E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.03|P-value:2.06E-5 ID:SGTC_1627|Compound:st003713|FD-Score:-3.79|P-value:5.41E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.02|P-value:2.22E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.86|P-value:4.04E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.49|P-value:1.81E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.08|P-value:8.34E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.98|P-value:2.57E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.04|P-value:9.64E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.12|P-value:7.49E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.51|P-value:1.79E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.19|P-value:6.00E-4 ID:SGTC_2165|Compound:5727197|FD-Score:6.25|P-value:9.85E-11 ID:SGTC_2348|Compound:9022543|FD-Score:-3.89|P-value:3.56E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-3.79|P-value:5.52E-5 ID:SGTC_2350|Compound:9023895|FD-Score:5.33|P-value:2.93E-8 ID:SGTC_2363|Compound:9053361|FD-Score:3.17|P-value:6.47E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.46|P-value:2.59E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.56|P-value:1.76E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.66|P-value:9.22E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.33|P-value:3.39E-4 ID:SGTC_2625|Compound:euphol|FD-Score:6.73|P-value:3.82E-12 ID:SGTC_2781|Compound:5567276|FD-Score:-3.56|P-value:1.40E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.20|P-value:5.41E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.69|P-value:8.15E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.57|P-value:1.41E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.15|P-value:6.37E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.44|P-value:2.35E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.31|P-value:5.75E-6 ID:SGTC_2927|Compound:9011802|FD-Score:-3.33|P-value:3.31E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.77|P-value:6.31E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.38|P-value:3.00E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.12|P-value:7.26E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.47|P-value:2.00E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.58|P-value:1.37E-4

Top fitness defect scores for YLR151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2625 euphol 6.73 100.0 µM 3.82E-12 1 8.72E-12
2 SGTC_2165 5727197 6.25 32.1 µM 9.85E-11 12 2.01E-10
3 SGTC_2350 9023895 5.33 38.9 µM 2.93E-8 ergosterol biosynthesis 16 4.90E-8
4 SGTC_88 0180-0332 5.30 8.7 µM 3.48E-8 3 5.78E-8
5 SGTC_154 3389-1638 5.07 511.1 µM 1.27E-7 8 2.02E-7
6 SGTC_581 0958-0271 5.03 211.0 µM 1.58E-7 25 2.50E-7
7 SGTC_2574 2',4'-dihydroxychalcone 4.56 14.6 µM 1.76E-6 12 2.56E-6
8 SGTC_944 3370-0224 4.49 231.0 µM 2.45E-6 15 3.53E-6
9 SGTC_2870 9038528 4.31 13.0 µM 5.75E-6 15 8.04E-6
10 SGTC_1013 4112-3890 4.10 241.0 µM 1.52E-5 TSC3-RPN4 29 2.06E-5
11 SGTC_1522 st012842 4.03 45.6 µM 2.06E-5 RNA pol III & RNase P/MRP 24 2.75E-5
12 SGTC_1784 st039334 4.02 36.3 µM 2.22E-5 19 2.96E-5
13 SGTC_2001 4023502 3.98 57.7 µM 2.57E-5 mitochondrial processes 16 3.42E-5
14 SGTC_831 k061-1017 3.85 217.0 µM 4.57E-5 translation 69 5.96E-5
15 SGTC_3068 9116768 3.77 49.5 µM 6.31E-5 22 8.15E-5
16 SGTC_1009 4106-0057 3.75 9.9 µM 6.77E-5 18 8.72E-5
17 SGTC_89 0302-0250 3.72 142.1 µM 7.73E-5 25 9.91E-5
18 SGTC_947 3447-0010 3.69 211.0 µM 8.88E-5 17 1.13E-4
19 SGTC_1130 3454-2858 3.62 15.9 µM 1.15E-4 NEO1 104 1.46E-4
20 SGTC_1633 st005664 3.62 67.9 µM 1.18E-4 44 1.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.61E-13 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 1.83E-9 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.092 9.37E-8 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.082 1.71E-6 YPL219W PCL8 hom Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
0.077 9.10E-6 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.075 1.25E-5 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.075 1.30E-5 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.074 1.62E-5 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.073 2.17E-5 YBR015C MNN2 hom Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.073 2.27E-5 YML120C NDI1 hom NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID
0.073 2.57E-5 YGL197W MDS3 hom Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
0.072 2.75E-5 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.072 2.93E-5 YPR171W BSP1 hom Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
0.072 3.12E-5 YNL204C SPS18 hom Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
0.071 4.30E-5 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)