YLR153C / ACS2

Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR153C / ACS2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.56|P-value:4.27E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.43|P-value:7.65E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:4.19|P-value:1.51E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.63|P-value:5.50E-9 ID:SGTC_115|Compound:0527-0192|FD-Score:5.15|P-value:4.54E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:3.99|P-value:2.91E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.37|P-value:1.99E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:4.41|P-value:7.24E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.61|P-value:9.18E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:6.23|P-value:3.93E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:4.02|P-value:2.61E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.36|P-value:8.67E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.22|P-value:1.38E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:14.30|P-value:2.30E-35 ID:SGTC_507|Compound:nimesulide|FD-Score:-4.11|P-value:1.99E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:10.70|P-value:1.45E-20 ID:SGTC_640|Compound:3381-0960|FD-Score:4.02|P-value:2.66E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.23|P-value:1.34E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.39|P-value:1.78E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:9.34|P-value:4.00E-16 ID:SGTC_795|Compound:0685-0265|FD-Score:6.08|P-value:8.11E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:8.07|P-value:1.70E-12 ID:SGTC_902|Compound:1120-0002|FD-Score:5.43|P-value:1.41E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:3.59|P-value:9.94E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.65|P-value:8.38E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:5.03|P-value:7.15E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:4.18|P-value:1.56E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.67|P-value:7.87E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.90|P-value:1.19E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.51|P-value:5.09E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:6.18|P-value:4.98E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:8.86|P-value:1.12E-14 ID:SGTC_1367|Compound:1812-0510|FD-Score:-11.70|P-value:3.63E-24 ID:SGTC_1590|Compound:st077108|FD-Score:5.58|P-value:7.44E-7 ID:SGTC_1591|Compound:genipin|FD-Score:3.69|P-value:7.28E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.36|P-value:8.48E-5 ID:SGTC_1749|Compound:st037932|FD-Score:4.03|P-value:2.59E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.31|P-value:1.02E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.88|P-value:4.18E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.09|P-value:2.12E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.05|P-value:2.43E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.65|P-value:8.32E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.81|P-value:1.70E-5 ID:SGTC_2869|Compound:9037858|FD-Score:4.11|P-value:2.00E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.80|P-value:5.30E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.56|P-value:4.25E-5 ID:SGTC_3120|Compound:9124077|FD-Score:7.49|P-value:5.42E-11 ID:SGTC_3288|Compound:9119690|FD-Score:6.91|P-value:1.31E-9 ID:SGTC_3304|Compound:9125678|FD-Score:27.50|P-value:9.82E-125 ID:SGTC_36|Compound:0335-0881|FD-Score:4.56|P-value:4.27E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.43|P-value:7.65E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:4.19|P-value:1.51E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.63|P-value:5.50E-9 ID:SGTC_115|Compound:0527-0192|FD-Score:5.15|P-value:4.54E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:3.99|P-value:2.91E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.37|P-value:1.99E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:4.41|P-value:7.24E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.61|P-value:9.18E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:6.23|P-value:3.93E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:4.02|P-value:2.61E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.36|P-value:8.67E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.22|P-value:1.38E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:14.30|P-value:2.30E-35 ID:SGTC_507|Compound:nimesulide|FD-Score:-4.11|P-value:1.99E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:10.70|P-value:1.45E-20 ID:SGTC_640|Compound:3381-0960|FD-Score:4.02|P-value:2.66E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.23|P-value:1.34E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.39|P-value:1.78E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:9.34|P-value:4.00E-16 ID:SGTC_795|Compound:0685-0265|FD-Score:6.08|P-value:8.11E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:8.07|P-value:1.70E-12 ID:SGTC_902|Compound:1120-0002|FD-Score:5.43|P-value:1.41E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:3.59|P-value:9.94E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.65|P-value:8.38E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:5.03|P-value:7.15E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:4.18|P-value:1.56E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.67|P-value:7.87E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.90|P-value:1.19E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.51|P-value:5.09E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:6.18|P-value:4.98E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:8.86|P-value:1.12E-14 ID:SGTC_1367|Compound:1812-0510|FD-Score:-11.70|P-value:3.63E-24 ID:SGTC_1590|Compound:st077108|FD-Score:5.58|P-value:7.44E-7 ID:SGTC_1591|Compound:genipin|FD-Score:3.69|P-value:7.28E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.36|P-value:8.48E-5 ID:SGTC_1749|Compound:st037932|FD-Score:4.03|P-value:2.59E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.31|P-value:1.02E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.88|P-value:4.18E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.09|P-value:2.12E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.05|P-value:2.43E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.65|P-value:8.32E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.81|P-value:1.70E-5 ID:SGTC_2869|Compound:9037858|FD-Score:4.11|P-value:2.00E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.80|P-value:5.30E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.56|P-value:4.25E-5 ID:SGTC_3120|Compound:9124077|FD-Score:7.49|P-value:5.42E-11 ID:SGTC_3288|Compound:9119690|FD-Score:6.91|P-value:1.31E-9 ID:SGTC_3304|Compound:9125678|FD-Score:27.50|P-value:9.82E-125

Top fitness defect scores for YLR153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3304 9125678 27.50 46.1 µM 9.82E-125 4 4.44E-167 3.48
2 SGTC_451 chloral hydrate 14.30 100.0 µM 2.30E-35 2 6.81E-47 7.67
3 SGTC_528 3492-0019 10.70 172.0 µM 1.45E-20 calcium & mitochondrial duress 3 5.15E-27 2.01
4 SGTC_794 k038-0031 9.34 316.0 µM 4.00E-16 ubiquinone biosynthesis & proteasome 3 4.65E-21 0.79
5 SGTC_1317 1273-0028 8.86 910.0 nM 1.12E-14 azole & statin 3 4.07E-19 1.06
6 SGTC_851 0394-0702 8.07 453.0 µM 1.70E-12 mitochondrial processes 5 3.39E-16 1.62
7 SGTC_3120 9124077 7.49 49.5 µM 5.42E-11 9 3.49E-14 1.34
8 SGTC_63 0099-0242 7.43 26.7 µM 7.65E-11 mitochondrial stress 9 5.54E-14 1.47
9 SGTC_3288 9119690 6.91 36.2 µM 1.31E-9 9 2.47E-12 0.62
10 SGTC_69 0096-0274 6.63 206.7 µM 5.50E-9 mitochondrial processes 16 1.69E-11 0.16
11 SGTC_676 falcarinol 6.39 140.0 µM 1.78E-8 3 8.07E-11 1.04
12 SGTC_158 k038-0087 6.37 26.4 µM 1.99E-8 ubiquinone biosynthesis & proteasome 13 9.40E-11 0.30
13 SGTC_273 hydroxyurea 6.23 18.1 mM 3.93E-8 heme biosynthesis & mitochondrial translocase 4 2.33E-10 0.37
14 SGTC_1255 0566-0045 6.18 221.0 µM 4.98E-8 excess fatty acid 5 3.20E-10 0.10
15 SGTC_795 0685-0265 6.08 78.0 µM 8.11E-8 excess fatty acid 3 6.13E-10 0.10
16 SGTC_1590 st077108 5.58 57.8 µM 7.44E-7 2 1.18E-8 0.54
17 SGTC_902 1120-0002 5.43 2.1 µM 1.41E-6 azole & statin 10 2.77E-8 0.01
18 SGTC_115 0527-0192 5.15 112.0 µM 4.54E-6 8 1.31E-7 0.10
19 SGTC_924 2046-0044 5.03 21.3 µM 7.15E-6 2 2.40E-7 0.35
20 SGTC_1168 k815-0004 4.90 80.5 µM 1.19E-5 DNA damage response 9 4.76E-7 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.483 1.63E-195 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.475 2.81E-188 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.365 2.68E-106 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.333 1.49E-87 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.315 3.00E-78 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.239 7.76E-45 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.232 2.62E-42 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.205 4.94E-33 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.193 1.29E-29 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.191 5.39E-29 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.182 2.52E-26 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.167 1.86E-22 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.160 1.00E-20 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.159 2.05E-20 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.155 2.14E-19 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance