YLR163C / MAS1

Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR163C / MAS1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:5.13|P-value:3.81E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:4.44|P-value:3.01E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.38|P-value:3.60E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:7.18|P-value:1.60E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:4.35|P-value:3.86E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.17|P-value:6.33E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.71|P-value:5.33E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:8.16|P-value:1.70E-10 ID:SGTC_229|Compound:benomyl|FD-Score:7.31|P-value:9.34E-9 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.60|P-value:2.39E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.43|P-value:3.94E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.83|P-value:9.91E-8 ID:SGTC_584|Compound:0986-0246|FD-Score:5.51|P-value:1.06E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-4.29|P-value:5.71E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.46|P-value:2.87E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-4.21|P-value:7.09E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:7.66|P-value:1.86E-9 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.69|P-value:1.84E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.87|P-value:8.59E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.12|P-value:7.30E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.16|P-value:6.55E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:5.13|P-value:3.76E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.46|P-value:3.56E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.54|P-value:2.25E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.68|P-value:1.52E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.17|P-value:6.37E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.18|P-value:1.65E-8 ID:SGTC_1632|Compound:st005650|FD-Score:4.31|P-value:4.35E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-4.10|P-value:9.47E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.55|P-value:9.35E-6 ID:SGTC_1716|Compound:st033144|FD-Score:-4.21|P-value:7.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.65|P-value:8.87E-6 ID:SGTC_1731|Compound:st035964|FD-Score:-4.24|P-value:6.55E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.27|P-value:6.01E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.49|P-value:2.63E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.72|P-value:5.13E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-5.78|P-value:5.59E-6 ID:SGTC_1911|Compound:st060208|FD-Score:4.98|P-value:6.01E-5 ID:SGTC_1916|Compound:st067606|FD-Score:6.54|P-value:2.33E-7 ID:SGTC_1968|Compound:st069590|FD-Score:-4.11|P-value:9.19E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.36|P-value:3.79E-4 ID:SGTC_2151|Compound:5563267|FD-Score:7.15|P-value:1.87E-8 ID:SGTC_2174|Compound:5790901|FD-Score:12.40|P-value:9.03E-22 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.53|P-value:9.92E-6 ID:SGTC_2319|Compound:6033012|FD-Score:5.44|P-value:1.34E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-5.93|P-value:3.27E-6 ID:SGTC_2350|Compound:9023895|FD-Score:-4.88|P-value:1.06E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.85|P-value:8.96E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.50|P-value:2.53E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.54|P-value:9.73E-6 ID:SGTC_2671|Compound:danthron|FD-Score:-4.10|P-value:9.40E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-4.15|P-value:8.28E-4 ID:SGTC_2870|Compound:9038528|FD-Score:7.76|P-value:1.19E-9 ID:SGTC_2924|Compound:9010168|FD-Score:-5.62|P-value:9.60E-6 ID:SGTC_3081|Compound:9117243|FD-Score:4.73|P-value:1.28E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.47|P-value:2.76E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-5.44|P-value:1.79E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-4.98|P-value:7.84E-5 ID:SGTC_3113|Compound:9123498|FD-Score:4.97|P-value:6.16E-5 ID:SGTC_3126|Compound:9127922|FD-Score:5.54|P-value:9.50E-6 ID:SGTC_3129|Compound:9127257|FD-Score:-4.17|P-value:7.90E-4 ID:SGTC_3130|Compound:9127414|FD-Score:5.17|P-value:3.26E-5 ID:SGTC_3142|Compound:9086498|FD-Score:6.62|P-value:1.70E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-5.39|P-value:2.14E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:5.13|P-value:3.81E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:4.44|P-value:3.01E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.38|P-value:3.60E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:7.18|P-value:1.60E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:4.35|P-value:3.86E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.17|P-value:6.33E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.71|P-value:5.33E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:8.16|P-value:1.70E-10 ID:SGTC_229|Compound:benomyl|FD-Score:7.31|P-value:9.34E-9 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.60|P-value:2.39E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.43|P-value:3.94E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.83|P-value:9.91E-8 ID:SGTC_584|Compound:0986-0246|FD-Score:5.51|P-value:1.06E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-4.29|P-value:5.71E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.46|P-value:2.87E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-4.21|P-value:7.09E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:7.66|P-value:1.86E-9 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.69|P-value:1.84E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.87|P-value:8.59E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.12|P-value:7.30E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.16|P-value:6.55E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:5.13|P-value:3.76E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.46|P-value:3.56E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.54|P-value:2.25E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.68|P-value:1.52E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.17|P-value:6.37E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.18|P-value:1.65E-8 ID:SGTC_1632|Compound:st005650|FD-Score:4.31|P-value:4.35E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-4.10|P-value:9.47E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.55|P-value:9.35E-6 ID:SGTC_1716|Compound:st033144|FD-Score:-4.21|P-value:7.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.65|P-value:8.87E-6 ID:SGTC_1731|Compound:st035964|FD-Score:-4.24|P-value:6.55E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.27|P-value:6.01E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.49|P-value:2.63E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.72|P-value:5.13E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-5.78|P-value:5.59E-6 ID:SGTC_1911|Compound:st060208|FD-Score:4.98|P-value:6.01E-5 ID:SGTC_1916|Compound:st067606|FD-Score:6.54|P-value:2.33E-7 ID:SGTC_1968|Compound:st069590|FD-Score:-4.11|P-value:9.19E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.36|P-value:3.79E-4 ID:SGTC_2151|Compound:5563267|FD-Score:7.15|P-value:1.87E-8 ID:SGTC_2174|Compound:5790901|FD-Score:12.40|P-value:9.03E-22 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.53|P-value:9.92E-6 ID:SGTC_2319|Compound:6033012|FD-Score:5.44|P-value:1.34E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-5.93|P-value:3.27E-6 ID:SGTC_2350|Compound:9023895|FD-Score:-4.88|P-value:1.06E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.85|P-value:8.96E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.50|P-value:2.53E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.54|P-value:9.73E-6 ID:SGTC_2671|Compound:danthron|FD-Score:-4.10|P-value:9.40E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-4.15|P-value:8.28E-4 ID:SGTC_2870|Compound:9038528|FD-Score:7.76|P-value:1.19E-9 ID:SGTC_2924|Compound:9010168|FD-Score:-5.62|P-value:9.60E-6 ID:SGTC_3081|Compound:9117243|FD-Score:4.73|P-value:1.28E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.47|P-value:2.76E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-5.44|P-value:1.79E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-4.98|P-value:7.84E-5 ID:SGTC_3113|Compound:9123498|FD-Score:4.97|P-value:6.16E-5 ID:SGTC_3126|Compound:9127922|FD-Score:5.54|P-value:9.50E-6 ID:SGTC_3129|Compound:9127257|FD-Score:-4.17|P-value:7.90E-4 ID:SGTC_3130|Compound:9127414|FD-Score:5.17|P-value:3.26E-5 ID:SGTC_3142|Compound:9086498|FD-Score:6.62|P-value:1.70E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-5.39|P-value:2.14E-5

Top fitness defect scores for YLR163C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2174 5790901 12.40 200.0 µM 9.03E-22 tubulin folding & SWR complex 1 1.51E-35 4.08
2 SGTC_212 3807-4682 8.16 38.8 µM 1.70E-10 tubulin folding & SWR complex 7 1.65E-16 0.42
3 SGTC_2870 9038528 7.76 13.0 µM 1.19E-9 1 4.35E-15 3.11
4 SGTC_999 4022-0066 7.66 22.7 µM 1.86E-9 Golgi 4 9.24E-15 1.30
5 SGTC_229 benomyl 7.31 22.9 µM 9.34E-9 tubulin folding & SWR complex 7 1.38E-13 0.95
6 SGTC_171 k064-0041 7.18 9.7 µM 1.60E-8 heme requiring 4 3.41E-13 0.00
7 SGTC_1597 7-benzyloxygramine 7.18 47.5 µM 1.65E-8 calcium & mitochondrial duress 27 3.60E-13 0.08
8 SGTC_2151 5563267 7.15 85.4 µM 1.87E-8 9 4.46E-13 1.78
9 SGTC_3142 9086498 6.62 49.5 µM 1.70E-7 iron homeostasis 20 1.79E-11 0.18
10 SGTC_1916 st067606 6.54 49.2 µM 2.33E-7 1 3.04E-11 1.79
11 SGTC_1875 nocodazole 5.72 6.0 µM 5.13E-6 tubulin folding & SWR complex 17 5.28E-9 0.03
12 SGTC_207 4185-0010 5.71 4.5 µM 5.33E-6 endomembrane recycling 10 5.61E-9 0.75
13 SGTC_1643 st009866 5.55 20.2 µM 9.35E-6 12 1.43E-8 0.07
14 SGTC_3126 9127922 5.54 49.5 µM 9.50E-6 fatty acid desaturase (OLE1) 12 1.47E-8 0.14
15 SGTC_2619 obliquin 5.54 87.9 µM 9.73E-6 cell wall 18 1.53E-8 0.08
16 SGTC_2250 alverine citrate 5.53 130.0 µM 9.92E-6 20 1.58E-8 0.44
17 SGTC_584 0986-0246 5.51 15.4 µM 1.06E-5 heme requiring 9 1.78E-8 0.14
18 SGTC_2319 6033012 5.44 152.6 µM 1.34E-5 tubulin folding & SWR complex 2 2.60E-8 0.95
19 SGTC_3130 9127414 5.17 49.5 µM 3.26E-5 2 1.14E-7 0.84
20 SGTC_1151 3909-8316 5.13 15.3 µM 3.76E-5 4 1.44E-7 0.60

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.285 8.90E-64 YLR197W NOP56 het Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
0.235 2.07E-43 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.234 6.26E-43 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.217 6.78E-37 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.200 1.21E-31 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.191 1.09E-28 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.184 5.49E-27 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.182 1.96E-26 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.182 2.51E-26 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.174 3.42E-24 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.168 1.74E-22 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.164 1.74E-21 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.159 1.97E-20 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.158 4.96E-20 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.157 5.74E-20 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl