YLR166C / SEC10

Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR166C / SEC10

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:4.19|P-value:3.79E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.33|P-value:5.66E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.91|P-value:1.14E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.87|P-value:1.26E-8 ID:SGTC_179|Compound:1273-0063|FD-Score:3.35|P-value:8.05E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.46|P-value:5.51E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.69|P-value:2.52E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.26|P-value:1.69E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.70|P-value:1.57E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.80|P-value:1.69E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.23|P-value:1.95E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.03|P-value:7.09E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.41|P-value:6.63E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.63|P-value:6.00E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.31|P-value:6.06E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.51|P-value:3.06E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.47|P-value:5.38E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-5.44|P-value:6.47E-8 ID:SGTC_1816|Compound:st051957|FD-Score:4.03|P-value:7.00E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.41|P-value:1.52E-5 ID:SGTC_1836|Compound:st055642|FD-Score:5.44|P-value:1.22E-7 ID:SGTC_1964|Compound:st076914|FD-Score:5.65|P-value:4.27E-8 ID:SGTC_2089|Compound:5281248|FD-Score:3.44|P-value:5.96E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-5.11|P-value:3.51E-7 ID:SGTC_2099|Compound:5377090|FD-Score:-3.98|P-value:5.28E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.29|P-value:9.83E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.26|P-value:7.22E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.69|P-value:4.56E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-3.24|P-value:7.71E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.23|P-value:3.21E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-5.19|P-value:2.33E-7 ID:SGTC_2274|Compound:7947094|FD-Score:-6.32|P-value:4.81E-10 ID:SGTC_2325|Compound:6158266|FD-Score:4.23|P-value:3.21E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.47|P-value:5.32E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.67|P-value:2.74E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.59|P-value:2.32E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.63|P-value:2.04E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.13|P-value:4.71E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.64|P-value:3.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.26|P-value:2.88E-5 ID:SGTC_2855|Compound:9016525|FD-Score:4.00|P-value:8.05E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.51|P-value:3.04E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.35|P-value:1.99E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.65|P-value:5.29E-6 ID:SGTC_3235|Compound:9132602|FD-Score:3.50|P-value:4.81E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.38|P-value:7.37E-4 ID:SGTC_57|Compound:miconazole|FD-Score:4.19|P-value:3.79E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.33|P-value:5.66E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.91|P-value:1.14E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.87|P-value:1.26E-8 ID:SGTC_179|Compound:1273-0063|FD-Score:3.35|P-value:8.05E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.46|P-value:5.51E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.69|P-value:2.52E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.26|P-value:1.69E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.70|P-value:1.57E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.80|P-value:1.69E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.23|P-value:1.95E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.03|P-value:7.09E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.41|P-value:6.63E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.63|P-value:6.00E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.31|P-value:6.06E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.51|P-value:3.06E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.47|P-value:5.38E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-5.44|P-value:6.47E-8 ID:SGTC_1816|Compound:st051957|FD-Score:4.03|P-value:7.00E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.41|P-value:1.52E-5 ID:SGTC_1836|Compound:st055642|FD-Score:5.44|P-value:1.22E-7 ID:SGTC_1964|Compound:st076914|FD-Score:5.65|P-value:4.27E-8 ID:SGTC_2089|Compound:5281248|FD-Score:3.44|P-value:5.96E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-5.11|P-value:3.51E-7 ID:SGTC_2099|Compound:5377090|FD-Score:-3.98|P-value:5.28E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.29|P-value:9.83E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.26|P-value:7.22E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.69|P-value:4.56E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-3.24|P-value:7.71E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.23|P-value:3.21E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-5.19|P-value:2.33E-7 ID:SGTC_2274|Compound:7947094|FD-Score:-6.32|P-value:4.81E-10 ID:SGTC_2325|Compound:6158266|FD-Score:4.23|P-value:3.21E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.47|P-value:5.32E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.67|P-value:2.74E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.59|P-value:2.32E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.63|P-value:2.04E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.13|P-value:4.71E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.64|P-value:3.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.26|P-value:2.88E-5 ID:SGTC_2855|Compound:9016525|FD-Score:4.00|P-value:8.05E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.51|P-value:3.04E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.35|P-value:1.99E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.65|P-value:5.29E-6 ID:SGTC_3235|Compound:9132602|FD-Score:3.50|P-value:4.81E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.38|P-value:7.37E-4

Top fitness defect scores for YLR166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_178 4092-0806 5.87 87.5 µM 1.26E-8 ergosterol depletion effects on membrane 13 2.16E-9 0.46
2 SGTC_1964 st076914 5.65 61.0 µM 4.27E-8 RPP1 & pyrimidine depletion 2 8.22E-9 0.71
3 SGTC_1836 st055642 5.44 81.0 µM 1.22E-7 2 2.59E-8 1.11
4 SGTC_2263 7948595 4.69 193.3 µM 4.56E-6 2 1.38E-6 0.43
5 SGTC_3210 9128157 4.65 49.5 µM 5.29E-6 6 1.62E-6 0.12
6 SGTC_1403 3909-7815 4.63 62.9 µM 6.00E-6 2 1.86E-6 0.22
7 SGTC_1824 st053723 4.41 68.6 µM 1.52E-5 2 5.17E-6 0.12
8 SGTC_2974 9094440 4.35 9.7 µM 1.99E-5 ergosterol biosynthesis 10 6.93E-6 0.04
9 SGTC_2821 7996764 4.26 71.4 µM 2.88E-5 8 1.04E-5 0.01
10 SGTC_2269 7935389 4.23 174.4 µM 3.21E-5 tubulin folding & SWR complex 4 1.17E-5 0.02
11 SGTC_2325 6158266 4.23 200.0 µM 3.21E-5 5 1.17E-5 0.44
12 SGTC_57 miconazole 4.19 162.5 nM 3.79E-5 ergosterol depletion effects on membrane 23 1.40E-5 0.08
13 SGTC_2543 pimpinellin 4.13 60.7 µM 4.71E-5 Golgi 3 1.79E-5 0.39
14 SGTC_1816 st051957 4.03 91.6 µM 7.00E-5 1 2.76E-5 0.37
15 SGTC_1371 2421-0008 4.03 32.7 µM 7.09E-5 mitochondrial processes 23 2.80E-5 0.08
16 SGTC_2855 9016525 4.00 58.4 µM 8.05E-5 4 3.22E-5 0.10
17 SGTC_1408 3909-7976 3.94 48.8 µM 1.00E-4 Golgi 6 4.10E-5 0.43
18 SGTC_175 3793-3120 3.91 23.7 µM 1.14E-4 5 4.71E-5 0.04
19 SGTC_1195 1502-0147 3.80 41.1 µM 1.69E-4 7 7.26E-5 0.27
20 SGTC_535 2293-4129 3.69 48.2 µM 2.52E-4 NEO1 13 1.12E-4 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.79E-10 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.083 1.51E-6 YFR022W ROG3 hom Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication
0.081 2.48E-6 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.080 3.30E-6 YGL160W AIM14 hom NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
0.075 1.30E-5 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.073 2.35E-5 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.072 2.93E-5 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.070 5.16E-5 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.069 6.53E-5 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.067 1.05E-4 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.065 1.56E-4 YJL156C SSY5 het Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p
0.065 1.59E-4 YKR004C ECM9 het Non-essential protein of unknown function
0.065 1.61E-4 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.064 2.22E-4 YLR296W_d YLR296W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.063 2.48E-4 YJL163C_p YJL163C_p hom Putative protein of unknown function