YLR168C / UPS2

Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR168C / UPS2

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.77|P-value:6.74E-7 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.11|P-value:8.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.94|P-value:3.33E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:3.88|P-value:4.26E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.10|P-value:8.38E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.75|P-value:7.30E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:3.90|P-value:3.88E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.10|P-value:8.56E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.35|P-value:3.47E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.17|P-value:6.59E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.44|P-value:2.48E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.14|P-value:1.34E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.52|P-value:1.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.24|P-value:4.58E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-4.85|P-value:3.78E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:3.92|P-value:3.54E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.44|P-value:2.47E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.13|P-value:7.53E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.34|P-value:3.60E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.73|P-value:8.01E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.64|P-value:1.00E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.75|P-value:7.39E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.99|P-value:2.29E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.97|P-value:2.83E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.10|P-value:8.56E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.63|P-value:1.04E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.20|P-value:5.42E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.04|P-value:9.55E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.53|P-value:1.75E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.10|P-value:1.59E-5 ID:SGTC_2316|Compound:5844804|FD-Score:7.59|P-value:6.58E-15 ID:SGTC_2318|Compound:6029776|FD-Score:-4.56|P-value:1.59E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-5.71|P-value:2.91E-9 ID:SGTC_2339|Compound:9000433|FD-Score:4.27|P-value:7.46E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-9.95|P-value:1.93E-24 ID:SGTC_2411|Compound:st077133|FD-Score:3.30|P-value:4.21E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.53|P-value:1.53E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.03|P-value:1.90E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-3.21|P-value:5.13E-4 ID:SGTC_2461|Compound:5755302|FD-Score:6.83|P-value:2.05E-12 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.59|P-value:1.65E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.53|P-value:1.55E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.73|P-value:7.05E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:5.29|P-value:4.06E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:10.10|P-value:4.23E-25 ID:SGTC_2736|Compound:butenafine|FD-Score:3.16|P-value:6.89E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.16|P-value:1.25E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.87|P-value:4.36E-5 ID:SGTC_2954|Compound:9074818|FD-Score:3.23|P-value:5.37E-4 ID:SGTC_2976|Compound:9009005|FD-Score:5.19|P-value:7.10E-8 ID:SGTC_3006|Compound:9075424|FD-Score:-3.54|P-value:1.48E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.46|P-value:2.29E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.86|P-value:4.53E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.07|P-value:1.88E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.51|P-value:1.89E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.02|P-value:2.36E-5 ID:SGTC_3288|Compound:9119690|FD-Score:3.32|P-value:3.89E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.20|P-value:5.30E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.77|P-value:6.74E-7 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.11|P-value:8.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.94|P-value:3.33E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:3.88|P-value:4.26E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.10|P-value:8.38E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.75|P-value:7.30E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:3.90|P-value:3.88E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.10|P-value:8.56E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.35|P-value:3.47E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.17|P-value:6.59E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.44|P-value:2.48E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.14|P-value:1.34E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.52|P-value:1.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.24|P-value:4.58E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-4.85|P-value:3.78E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:3.92|P-value:3.54E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.44|P-value:2.47E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.13|P-value:7.53E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.34|P-value:3.60E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.73|P-value:8.01E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.64|P-value:1.00E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.75|P-value:7.39E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.99|P-value:2.29E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.97|P-value:2.83E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.10|P-value:8.56E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.63|P-value:1.04E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.20|P-value:5.42E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.04|P-value:9.55E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.53|P-value:1.75E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.10|P-value:1.59E-5 ID:SGTC_2316|Compound:5844804|FD-Score:7.59|P-value:6.58E-15 ID:SGTC_2318|Compound:6029776|FD-Score:-4.56|P-value:1.59E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-5.71|P-value:2.91E-9 ID:SGTC_2339|Compound:9000433|FD-Score:4.27|P-value:7.46E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-9.95|P-value:1.93E-24 ID:SGTC_2411|Compound:st077133|FD-Score:3.30|P-value:4.21E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.53|P-value:1.53E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.03|P-value:1.90E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-3.21|P-value:5.13E-4 ID:SGTC_2461|Compound:5755302|FD-Score:6.83|P-value:2.05E-12 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.59|P-value:1.65E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.53|P-value:1.55E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.73|P-value:7.05E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:5.29|P-value:4.06E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:10.10|P-value:4.23E-25 ID:SGTC_2736|Compound:butenafine|FD-Score:3.16|P-value:6.89E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.16|P-value:1.25E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.87|P-value:4.36E-5 ID:SGTC_2954|Compound:9074818|FD-Score:3.23|P-value:5.37E-4 ID:SGTC_2976|Compound:9009005|FD-Score:5.19|P-value:7.10E-8 ID:SGTC_3006|Compound:9075424|FD-Score:-3.54|P-value:1.48E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.46|P-value:2.29E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.86|P-value:4.53E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.07|P-value:1.88E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.51|P-value:1.89E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.02|P-value:2.36E-5 ID:SGTC_3288|Compound:9119690|FD-Score:3.32|P-value:3.89E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.20|P-value:5.30E-4

Top fitness defect scores for YLR168C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2616 abietic acid 10.10 100.0 µM 4.23E-25 4 2.20E-24
2 SGTC_2316 5844804 7.59 197.4 µM 6.58E-15 2 1.62E-14
3 SGTC_2461 5755302 6.83 26.1 µM 2.05E-12 8 4.22E-12
4 SGTC_2614 arthonioic acid 5.29 13.4 µM 4.06E-8 5 6.18E-8
5 SGTC_2976 9009005 5.19 19.5 µM 7.10E-8 17 1.06E-7
6 SGTC_88 0180-0332 4.77 8.7 µM 6.74E-7 8 9.42E-7
7 SGTC_2496 diffractaic acid 4.59 79.8 µM 1.65E-6 13 2.24E-6
8 SGTC_2339 9000433 4.27 200.0 µM 7.46E-6 28 9.71E-6
9 SGTC_2831 7999036 4.16 19.5 µM 1.25E-5 36 1.60E-5
10 SGTC_1032 k061-1018 4.14 98.7 µM 1.34E-5 16 1.71E-5
11 SGTC_2274 7947094 4.10 46.1 µM 1.59E-5 33 2.03E-5
12 SGTC_3076 9116187 4.07 49.5 µM 1.88E-5 16 2.38E-5
13 SGTC_3286 9117135 4.02 37.2 µM 2.36E-5 11 2.97E-5
14 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.97 62.6 µM 2.83E-5 TSC3-RPN4 15 3.54E-5
15 SGTC_116 0155-0182 3.94 31.8 µM 3.33E-5 mitochondrial response to ROS 80 4.15E-5
16 SGTC_1078 idebenone 3.92 36.1 µM 3.54E-5 Golgi 43 4.40E-5
17 SGTC_331 k048-0133 3.90 24.5 µM 3.88E-5 RSC & ERG11 11 4.81E-5
18 SGTC_123 0083-0120 3.88 66.7 µM 4.26E-5 50 5.27E-5
19 SGTC_2921 7974240 3.87 10.7 µM 4.36E-5 60 5.39E-5
20 SGTC_3028 9087778 3.86 49.5 µM 4.53E-5 15 5.60E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.61E-12 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.119 5.21E-12 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.115 2.37E-11 YPL187W MF(ALPHA)1 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
0.111 1.15E-10 YPR083W MDM36 hom Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
0.109 2.56E-10 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.094 4.53E-8 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.088 2.89E-7 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.38E-7 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.083 1.67E-6 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
0.083 1.71E-6 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.082 1.94E-6 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.081 2.68E-6 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.080 3.54E-6 YML032C RAD52 hom Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
0.080 3.97E-6 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.15E-6 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation