YLR169W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR169W / YLR169W

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.10|P-value:4.04E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.88|P-value:1.79E-5 ID:SGTC_57|Compound:miconazole|FD-Score:5.63|P-value:7.02E-10 ID:SGTC_207|Compound:4185-0010|FD-Score:13.90|P-value:2.53E-50 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.50|P-value:3.75E-35 ID:SGTC_252|Compound:miconazole|FD-Score:5.77|P-value:2.69E-10 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.54|P-value:5.12E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:4.81|P-value:1.15E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:14.50|P-value:3.45E-55 ID:SGTC_320|Compound:4092-0846|FD-Score:6.64|P-value:4.85E-13 ID:SGTC_327|Compound:1273-0057|FD-Score:4.79|P-value:1.29E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.40|P-value:1.20E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:14.40|P-value:2.89E-54 ID:SGTC_447|Compound:ml7|FD-Score:12.70|P-value:1.68E-42 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.97|P-value:3.45E-14 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-2.99|P-value:7.35E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.07|P-value:3.21E-8 ID:SGTC_459|Compound:nigericin|FD-Score:8.75|P-value:2.67E-21 ID:SGTC_514|Compound:4466-0038|FD-Score:3.59|P-value:5.42E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.32|P-value:1.69E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:6.26|P-value:8.36E-12 ID:SGTC_669|Compound:0108-0021|FD-Score:4.22|P-value:2.75E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:4.57|P-value:4.35E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:7.45|P-value:6.04E-16 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.26|P-value:7.50E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.15|P-value:7.37E-15 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.31|P-value:2.16E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.25|P-value:2.32E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.89|P-value:1.71E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.05|P-value:5.03E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.39|P-value:1.55E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.09|P-value:4.19E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.89|P-value:9.10E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.37|P-value:1.67E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.69|P-value:3.42E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.71|P-value:5.66E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.89|P-value:9.11E-8 ID:SGTC_1672|Compound:st016598|FD-Score:3.23|P-value:2.50E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.40|P-value:1.24E-4 ID:SGTC_1750|Compound:st081859|FD-Score:20.30|P-value:1.95E-105 ID:SGTC_1754|Compound:st042065|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_2006|Compound:4011487|FD-Score:9.13|P-value:5.55E-23 ID:SGTC_2021|Compound:4019055|FD-Score:3.55|P-value:6.43E-5 ID:SGTC_2123|Compound:5259487|FD-Score:2.91|P-value:8.35E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.83|P-value:2.24E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:2.90|P-value:8.67E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.34|P-value:1.89E-4 ID:SGTC_2537|Compound:larixol|FD-Score:2.92|P-value:8.07E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.34|P-value:1.54E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.80|P-value:2.54E-17 ID:SGTC_2693|Compound:st077581|FD-Score:2.93|P-value:7.94E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.09|P-value:2.81E-11 ID:SGTC_2823|Compound:7987624|FD-Score:3.96|P-value:9.94E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.60|P-value:3.56E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.08|P-value:5.26E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.45|P-value:9.94E-5 ID:SGTC_2948|Compound:9070189|FD-Score:2.87|P-value:9.88E-4 ID:SGTC_2989|Compound:9073649|FD-Score:6.04|P-value:4.13E-11 ID:SGTC_2991|Compound:9074669|FD-Score:2.89|P-value:8.92E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.90|P-value:8.70E-4 ID:SGTC_3018|Compound:9082602|FD-Score:9.49|P-value:1.05E-24 ID:SGTC_3021|Compound:9087658|FD-Score:2.95|P-value:7.21E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.29|P-value:6.74E-12 ID:SGTC_3042|Compound:9091578|FD-Score:2.89|P-value:8.91E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.43|P-value:2.59E-9 ID:SGTC_3204|Compound:9114183|FD-Score:-4.62|P-value:4.23E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-4.49|P-value:8.57E-7 ID:SGTC_3308|Compound:9128332|FD-Score:5.04|P-value:2.88E-8 ID:SGTC_3311|Compound:9131146|FD-Score:3.10|P-value:4.15E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-2.98|P-value:7.72E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.02|P-value:6.63E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.61|P-value:5.94E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-5.66|P-value:7.74E-10 ID:SGTC_3355|Compound:9151058|FD-Score:-3.20|P-value:3.29E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.10|P-value:4.04E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.88|P-value:1.79E-5 ID:SGTC_57|Compound:miconazole|FD-Score:5.63|P-value:7.02E-10 ID:SGTC_207|Compound:4185-0010|FD-Score:13.90|P-value:2.53E-50 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.50|P-value:3.75E-35 ID:SGTC_252|Compound:miconazole|FD-Score:5.77|P-value:2.69E-10 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.54|P-value:5.12E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:4.81|P-value:1.15E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:14.50|P-value:3.45E-55 ID:SGTC_320|Compound:4092-0846|FD-Score:6.64|P-value:4.85E-13 ID:SGTC_327|Compound:1273-0057|FD-Score:4.79|P-value:1.29E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.40|P-value:1.20E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:14.40|P-value:2.89E-54 ID:SGTC_447|Compound:ml7|FD-Score:12.70|P-value:1.68E-42 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.97|P-value:3.45E-14 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-2.99|P-value:7.35E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.07|P-value:3.21E-8 ID:SGTC_459|Compound:nigericin|FD-Score:8.75|P-value:2.67E-21 ID:SGTC_514|Compound:4466-0038|FD-Score:3.59|P-value:5.42E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.32|P-value:1.69E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:6.26|P-value:8.36E-12 ID:SGTC_669|Compound:0108-0021|FD-Score:4.22|P-value:2.75E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:4.57|P-value:4.35E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:7.45|P-value:6.04E-16 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.26|P-value:7.50E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.15|P-value:7.37E-15 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.31|P-value:2.16E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.25|P-value:2.32E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.89|P-value:1.71E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.05|P-value:5.03E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.39|P-value:1.55E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.09|P-value:4.19E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.89|P-value:9.10E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.37|P-value:1.67E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.69|P-value:3.42E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.71|P-value:5.66E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.89|P-value:9.11E-8 ID:SGTC_1672|Compound:st016598|FD-Score:3.23|P-value:2.50E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.40|P-value:1.24E-4 ID:SGTC_1750|Compound:st081859|FD-Score:20.30|P-value:1.95E-105 ID:SGTC_1754|Compound:st042065|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_2006|Compound:4011487|FD-Score:9.13|P-value:5.55E-23 ID:SGTC_2021|Compound:4019055|FD-Score:3.55|P-value:6.43E-5 ID:SGTC_2123|Compound:5259487|FD-Score:2.91|P-value:8.35E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.83|P-value:2.24E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:2.90|P-value:8.67E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.34|P-value:1.89E-4 ID:SGTC_2537|Compound:larixol|FD-Score:2.92|P-value:8.07E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.34|P-value:1.54E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.80|P-value:2.54E-17 ID:SGTC_2693|Compound:st077581|FD-Score:2.93|P-value:7.94E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.09|P-value:2.81E-11 ID:SGTC_2823|Compound:7987624|FD-Score:3.96|P-value:9.94E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.60|P-value:3.56E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.08|P-value:5.26E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.45|P-value:9.94E-5 ID:SGTC_2948|Compound:9070189|FD-Score:2.87|P-value:9.88E-4 ID:SGTC_2989|Compound:9073649|FD-Score:6.04|P-value:4.13E-11 ID:SGTC_2991|Compound:9074669|FD-Score:2.89|P-value:8.92E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.90|P-value:8.70E-4 ID:SGTC_3018|Compound:9082602|FD-Score:9.49|P-value:1.05E-24 ID:SGTC_3021|Compound:9087658|FD-Score:2.95|P-value:7.21E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.29|P-value:6.74E-12 ID:SGTC_3042|Compound:9091578|FD-Score:2.89|P-value:8.91E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.43|P-value:2.59E-9 ID:SGTC_3204|Compound:9114183|FD-Score:-4.62|P-value:4.23E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-4.49|P-value:8.57E-7 ID:SGTC_3308|Compound:9128332|FD-Score:5.04|P-value:2.88E-8 ID:SGTC_3311|Compound:9131146|FD-Score:3.10|P-value:4.15E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-2.98|P-value:7.72E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.02|P-value:6.63E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.61|P-value:5.94E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-5.66|P-value:7.74E-10 ID:SGTC_3355|Compound:9151058|FD-Score:-3.20|P-value:3.29E-4

Top fitness defect scores for YLR169W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 20.30 2.4 µM 1.95E-105 endomembrane recycling 14 6.18E-92
2 SGTC_312 4092-0653 14.50 6.8 µM 3.45E-55 ergosterol depletion effects on membrane 4 3.34E-48
3 SGTC_445 e6 berbamine 14.40 66.0 µM 2.89E-54 NEO1-PIK1 2 2.13E-47
4 SGTC_207 4185-0010 13.90 4.5 µM 2.53E-50 endomembrane recycling 9 5.73E-44
5 SGTC_447 ml7 12.70 120.0 µM 1.68E-42 NEO1-PIK1 1 3.69E-37
6 SGTC_221 trifluoperazine 11.50 10.3 µM 3.75E-35 NEO1-PIK1 42 9.16E-31
7 SGTC_3018 9082602 9.49 49.5 µM 1.05E-24 14 1.13E-21
8 SGTC_2006 4011487 9.13 200.0 µM 5.55E-23 endomembrane recycling 24 3.57E-20
9 SGTC_459 nigericin 8.75 15.3 µM 2.67E-21 8 1.04E-18
10 SGTC_2688 kanamycin b 7.80 96.7 µM 2.54E-17 calcium & mitochondrial duress 72 3.01E-15
11 SGTC_788 1182-0090 7.45 188.0 µM 6.04E-16 endomembrane recycling 25 4.76E-14
12 SGTC_1130 3454-2858 7.15 15.9 µM 7.37E-15 NEO1 26 4.20E-13
13 SGTC_449 xestospongin c 6.97 11.2 µM 3.45E-14 NEO1-PIK1 12 1.61E-12
14 SGTC_320 4092-0846 6.64 5.3 µM 4.85E-13 ergosterol depletion effects on membrane 10 1.61E-11
15 SGTC_3037 9091026 6.29 49.5 µM 6.74E-12 NEO1-PIK1 41 1.59E-10
16 SGTC_649 1123-0311 6.26 367.0 µM 8.36E-12 endomembrane recycling 24 1.92E-10
17 SGTC_2778 tioconazole 6.09 65.1 nM 2.81E-11 ergosterol depletion effects on membrane 29 5.50E-10
18 SGTC_2989 9073649 6.04 71.4 µM 4.13E-11 8 7.70E-10
19 SGTC_252 miconazole 5.77 1.3 nM 2.69E-10 ergosterol depletion effects on membrane 19 3.94E-9
20 SGTC_57 miconazole 5.63 162.5 nM 7.02E-10 ergosterol depletion effects on membrane 13 9.07E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.626 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.622 0 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.613 0 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.593 7.09E-318 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.589 3.16E-313 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.513 3.01E-225 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.501 1.10E-212 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.413 2.13E-138 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.384 4.52E-118 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.363 1.04E-104 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.344 9.74E-94 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.343 5.27E-93 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.336 2.40E-89 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.326 4.41E-84 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.320 2.33E-80 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton