YLR171W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR171W / YLR171W

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-5.42|P-value:4.88E-8 ID:SGTC_36|Compound:0335-0881|FD-Score:4.67|P-value:2.62E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:4.77|P-value:1.67E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:5.61|P-value:2.19E-8 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.15|P-value:9.43E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.83|P-value:9.51E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.50|P-value:3.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:10.20|P-value:6.57E-24 ID:SGTC_149|Compound:3970-0822|FD-Score:-4.04|P-value:3.41E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.40|P-value:4.69E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.41|P-value:8.84E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:3.18|P-value:9.91E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.02|P-value:4.86E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:16.50|P-value:4.59E-59 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.12|P-value:2.97E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.70|P-value:1.69E-30 ID:SGTC_252|Compound:miconazole|FD-Score:5.92|P-value:3.93E-9 ID:SGTC_254|Compound:nsc-64875|FD-Score:8.92|P-value:1.49E-18 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.81|P-value:1.03E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.61|P-value:2.20E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:8.82|P-value:3.47E-18 ID:SGTC_320|Compound:4092-0846|FD-Score:4.44|P-value:7.59E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.57|P-value:4.13E-6 ID:SGTC_447|Compound:ml7|FD-Score:5.78|P-value:8.35E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.85|P-value:9.15E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.15|P-value:2.58E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.49|P-value:6.14E-6 ID:SGTC_482|Compound:fipronil|FD-Score:3.81|P-value:1.04E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.48|P-value:3.57E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.92|P-value:6.88E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:2.35E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.72|P-value:1.24E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.07|P-value:3.74E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.18|P-value:9.77E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:4.13|P-value:2.82E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:7.55|P-value:8.61E-14 ID:SGTC_716|Compound:1683-5115|FD-Score:3.79|P-value:1.14E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-4.52|P-value:4.27E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:6.59|P-value:6.15E-11 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.30|P-value:1.14E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.18|P-value:8.53E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.80|P-value:1.07E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.44|P-value:7.43E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.80|P-value:1.56E-11 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.59|P-value:2.37E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.55|P-value:2.70E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.19|P-value:9.70E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.54|P-value:2.87E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.87|P-value:8.08E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.15|P-value:2.66E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.36|P-value:5.45E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.72|P-value:1.44E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.08|P-value:3.53E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.74|P-value:1.13E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.24|P-value:1.82E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.30|P-value:6.55E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.31|P-value:6.44E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.00|P-value:4.13E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.44|P-value:1.66E-10 ID:SGTC_1547|Compound:harmine|FD-Score:3.57|P-value:2.56E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.29|P-value:6.96E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.51|P-value:3.24E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.89|P-value:8.76E-12 ID:SGTC_1829|Compound:berberine|FD-Score:4.14|P-value:2.78E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_2006|Compound:4011487|FD-Score:10.30|P-value:3.67E-24 ID:SGTC_2021|Compound:4019055|FD-Score:3.49|P-value:3.45E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:14.40|P-value:3.50E-45 ID:SGTC_2257|Compound:7960413|FD-Score:4.23|P-value:1.92E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.20|P-value:9.38E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.68|P-value:1.70E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.94|P-value:6.36E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.82|P-value:8.34E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.44|P-value:4.11E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.10|P-value:3.32E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.54|P-value:2.40E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.59|P-value:2.53E-8 ID:SGTC_2623|Compound:humulene|FD-Score:5.47|P-value:4.78E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.27|P-value:6.34E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.21|P-value:8.85E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.68|P-value:1.41E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.62|P-value:1.81E-17 ID:SGTC_2815|Compound:7968870|FD-Score:4.06|P-value:3.78E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-5.25|P-value:1.18E-7 ID:SGTC_2870|Compound:9038528|FD-Score:4.61|P-value:3.57E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.29|P-value:6.82E-4 ID:SGTC_2948|Compound:9070189|FD-Score:5.84|P-value:6.00E-9 ID:SGTC_2991|Compound:9074669|FD-Score:3.34|P-value:5.82E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.53|P-value:2.54E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.76|P-value:2.10E-11 ID:SGTC_3046|Compound:9092212|FD-Score:4.03|P-value:4.35E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.76|P-value:1.76E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.60|P-value:2.31E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.43|P-value:4.19E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-4.50|P-value:4.65E-6 ID:SGTC_3277|Compound:9138724|FD-Score:-4.14|P-value:2.31E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.02|P-value:4.45E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-5.42|P-value:4.88E-8 ID:SGTC_36|Compound:0335-0881|FD-Score:4.67|P-value:2.62E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:4.77|P-value:1.67E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:5.61|P-value:2.19E-8 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.15|P-value:9.43E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.83|P-value:9.51E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.50|P-value:3.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:10.20|P-value:6.57E-24 ID:SGTC_149|Compound:3970-0822|FD-Score:-4.04|P-value:3.41E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.40|P-value:4.69E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.41|P-value:8.84E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:3.18|P-value:9.91E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.02|P-value:4.86E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:16.50|P-value:4.59E-59 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.12|P-value:2.97E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.70|P-value:1.69E-30 ID:SGTC_252|Compound:miconazole|FD-Score:5.92|P-value:3.93E-9 ID:SGTC_254|Compound:nsc-64875|FD-Score:8.92|P-value:1.49E-18 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.81|P-value:1.03E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.61|P-value:2.20E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:8.82|P-value:3.47E-18 ID:SGTC_320|Compound:4092-0846|FD-Score:4.44|P-value:7.59E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.57|P-value:4.13E-6 ID:SGTC_447|Compound:ml7|FD-Score:5.78|P-value:8.35E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.85|P-value:9.15E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.15|P-value:2.58E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.49|P-value:6.14E-6 ID:SGTC_482|Compound:fipronil|FD-Score:3.81|P-value:1.04E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.48|P-value:3.57E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.92|P-value:6.88E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:2.35E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.72|P-value:1.24E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.07|P-value:3.74E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.18|P-value:9.77E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:4.13|P-value:2.82E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:7.55|P-value:8.61E-14 ID:SGTC_716|Compound:1683-5115|FD-Score:3.79|P-value:1.14E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-4.52|P-value:4.27E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:6.59|P-value:6.15E-11 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.30|P-value:1.14E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.18|P-value:8.53E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.80|P-value:1.07E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.44|P-value:7.43E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.80|P-value:1.56E-11 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.59|P-value:2.37E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.55|P-value:2.70E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.19|P-value:9.70E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.54|P-value:2.87E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.87|P-value:8.08E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.15|P-value:2.66E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.36|P-value:5.45E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.72|P-value:1.44E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.08|P-value:3.53E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.74|P-value:1.13E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.24|P-value:1.82E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.30|P-value:6.55E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.31|P-value:6.44E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.00|P-value:4.13E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.44|P-value:1.66E-10 ID:SGTC_1547|Compound:harmine|FD-Score:3.57|P-value:2.56E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.29|P-value:6.96E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.51|P-value:3.24E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.89|P-value:8.76E-12 ID:SGTC_1829|Compound:berberine|FD-Score:4.14|P-value:2.78E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_2006|Compound:4011487|FD-Score:10.30|P-value:3.67E-24 ID:SGTC_2021|Compound:4019055|FD-Score:3.49|P-value:3.45E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:14.40|P-value:3.50E-45 ID:SGTC_2257|Compound:7960413|FD-Score:4.23|P-value:1.92E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.20|P-value:9.38E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.68|P-value:1.70E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.94|P-value:6.36E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.82|P-value:8.34E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.44|P-value:4.11E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.10|P-value:3.32E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.54|P-value:2.40E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.59|P-value:2.53E-8 ID:SGTC_2623|Compound:humulene|FD-Score:5.47|P-value:4.78E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.27|P-value:6.34E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.21|P-value:8.85E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.68|P-value:1.41E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.62|P-value:1.81E-17 ID:SGTC_2815|Compound:7968870|FD-Score:4.06|P-value:3.78E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-5.25|P-value:1.18E-7 ID:SGTC_2870|Compound:9038528|FD-Score:4.61|P-value:3.57E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.29|P-value:6.82E-4 ID:SGTC_2948|Compound:9070189|FD-Score:5.84|P-value:6.00E-9 ID:SGTC_2991|Compound:9074669|FD-Score:3.34|P-value:5.82E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.53|P-value:2.54E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.76|P-value:2.10E-11 ID:SGTC_3046|Compound:9092212|FD-Score:4.03|P-value:4.35E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.76|P-value:1.76E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.60|P-value:2.31E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.43|P-value:4.19E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-4.50|P-value:4.65E-6 ID:SGTC_3277|Compound:9138724|FD-Score:-4.14|P-value:2.31E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.02|P-value:4.45E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.27|P-value:7.45E-4

Top fitness defect scores for YLR171W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 16.50 4.5 µM 4.59E-59 endomembrane recycling 6 1.20E-61
2 SGTC_2249 haloperidol 14.40 116.4 µM 3.50E-45 ergosterol depletion effects on membrane 2 3.71E-47
3 SGTC_221 trifluoperazine 11.70 10.3 µM 1.69E-30 NEO1-PIK1 40 7.93E-32
4 SGTC_2006 4011487 10.30 200.0 µM 3.67E-24 endomembrane recycling 18 3.29E-25
5 SGTC_146 3448-8650 10.20 53.1 µM 6.57E-24 NEO1-PIK1 17 6.05E-25
6 SGTC_254 nsc-64875 8.92 3.8 µM 1.49E-18 ergosterol depletion effects on membrane 9 2.37E-19
7 SGTC_312 4092-0653 8.82 6.8 µM 3.47E-18 ergosterol depletion effects on membrane 18 5.75E-19
8 SGTC_2778 tioconazole 8.62 65.1 nM 1.81E-17 ergosterol depletion effects on membrane 18 3.22E-18
9 SGTC_689 0833-0039 7.55 98.0 µM 8.61E-14 ergosterol depletion effects on membrane 7 2.24E-14
10 SGTC_1750 st081859 6.89 2.4 µM 8.76E-12 endomembrane recycling 89 2.80E-12
11 SGTC_1072 oxiconazole 6.80 14.9 nM 1.56E-11 ergosterol depletion effects on membrane 16 5.13E-12
12 SGTC_3037 9091026 6.76 49.5 µM 2.10E-11 NEO1-PIK1 33 6.98E-12
13 SGTC_788 1182-0090 6.59 188.0 µM 6.15E-11 endomembrane recycling 28 2.15E-11
14 SGTC_1514 1189-1591 6.44 158.0 µM 1.66E-10 10 6.05E-11
15 SGTC_252 miconazole 5.92 1.3 nM 3.93E-9 ergosterol depletion effects on membrane 17 1.66E-9
16 SGTC_2948 9070189 5.84 9.4 µM 6.00E-9 plasma membrane duress 23 2.58E-9
17 SGTC_447 ml7 5.78 120.0 µM 8.35E-9 NEO1-PIK1 11 3.64E-9
18 SGTC_55 0767-0285 5.61 6.6 µM 2.19E-8 19 9.97E-9
19 SGTC_514 4466-0038 5.60 2.6 nM 2.35E-8 cell wall 87 1.07E-8
20 SGTC_2619 obliquin 5.59 87.9 µM 2.53E-8 cell wall 85 1.16E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.613 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.559 4.42E-275 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.512 9.35E-224 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.501 1.10E-212 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.472 2.60E-185 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.472 2.65E-185 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.410 3.60E-136 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.402 3.77E-130 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.374 1.31E-111 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.360 3.06E-103 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.326 8.39E-84 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.326 1.29E-83 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.316 3.87E-78 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.298 8.08E-70 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.293 3.40E-67 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase