YLR176C / RFX1

Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR176C / RFX1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.26|P-value:3.66E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.16|P-value:5.40E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.18|P-value:4.95E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.16|P-value:5.46E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.03|P-value:8.15E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.30|P-value:3.18E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.07|P-value:7.10E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-4.30|P-value:4.02E-6 ID:SGTC_578|Compound:3460-0051|FD-Score:-5.40|P-value:1.03E-8 ID:SGTC_700|Compound:3453-2283|FD-Score:5.23|P-value:3.11E-8 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.46|P-value:1.65E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.99|P-value:1.82E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.19|P-value:6.88E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.08|P-value:6.80E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.75|P-value:5.25E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.66|P-value:7.54E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.39|P-value:2.28E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-4.12|P-value:9.57E-6 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.42|P-value:2.04E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.60|P-value:9.79E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:5.07|P-value:7.57E-8 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.82|P-value:3.85E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.80|P-value:4.26E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.28|P-value:3.42E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.55|P-value:1.19E-4 ID:SGTC_1687|Compound:st020778|FD-Score:-3.07|P-value:7.17E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:-4.23|P-value:5.55E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-4.45|P-value:1.97E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.62|P-value:8.90E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.10|P-value:6.73E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.63|P-value:8.75E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.32|P-value:3.90E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-3.07|P-value:7.15E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.77|P-value:4.69E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.14|P-value:5.76E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.22|P-value:3.16E-8 ID:SGTC_2186|Compound:6124449|FD-Score:-3.86|P-value:3.02E-5 ID:SGTC_2218|Compound:6965428|FD-Score:3.41|P-value:2.10E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.32|P-value:3.82E-6 ID:SGTC_2337|Compound:9009472|FD-Score:4.07|P-value:1.27E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.38|P-value:2.77E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.61|P-value:3.20E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.02|P-value:8.80E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.23|P-value:5.97E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.95|P-value:2.08E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:12.80|P-value:3.74E-40 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.33|P-value:2.73E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.67|P-value:6.78E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:7.51|P-value:3.64E-15 ID:SGTC_2602|Compound:kawain|FD-Score:6.55|P-value:5.95E-12 ID:SGTC_2796|Compound:7949634|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.06|P-value:1.34E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-2.99|P-value:9.41E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.32|P-value:3.59E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.63|P-value:8.62E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-3.03|P-value:8.37E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.27|P-value:3.54E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.99|P-value:1.78E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.32|P-value:3.96E-6 ID:SGTC_3254|Compound:9136651|FD-Score:4.19|P-value:7.14E-6 ID:SGTC_3292|Compound:9120825|FD-Score:4.98|P-value:1.28E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:3.26|P-value:3.66E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.16|P-value:5.40E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.18|P-value:4.95E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.16|P-value:5.46E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.03|P-value:8.15E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.30|P-value:3.18E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.07|P-value:7.10E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-4.30|P-value:4.02E-6 ID:SGTC_578|Compound:3460-0051|FD-Score:-5.40|P-value:1.03E-8 ID:SGTC_700|Compound:3453-2283|FD-Score:5.23|P-value:3.11E-8 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.46|P-value:1.65E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.99|P-value:1.82E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.19|P-value:6.88E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.08|P-value:6.80E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.75|P-value:5.25E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.66|P-value:7.54E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.39|P-value:2.28E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-4.12|P-value:9.57E-6 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.42|P-value:2.04E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.60|P-value:9.79E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:5.07|P-value:7.57E-8 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.82|P-value:3.85E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.80|P-value:4.26E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.28|P-value:3.42E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.55|P-value:1.19E-4 ID:SGTC_1687|Compound:st020778|FD-Score:-3.07|P-value:7.17E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:-4.23|P-value:5.55E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-4.45|P-value:1.97E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.62|P-value:8.90E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.10|P-value:6.73E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.63|P-value:8.75E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.32|P-value:3.90E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-3.07|P-value:7.15E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.77|P-value:4.69E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.14|P-value:5.76E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.22|P-value:3.16E-8 ID:SGTC_2186|Compound:6124449|FD-Score:-3.86|P-value:3.02E-5 ID:SGTC_2218|Compound:6965428|FD-Score:3.41|P-value:2.10E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.32|P-value:3.82E-6 ID:SGTC_2337|Compound:9009472|FD-Score:4.07|P-value:1.27E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.38|P-value:2.77E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.61|P-value:3.20E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.02|P-value:8.80E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.23|P-value:5.97E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.95|P-value:2.08E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:12.80|P-value:3.74E-40 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.33|P-value:2.73E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.67|P-value:6.78E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:7.51|P-value:3.64E-15 ID:SGTC_2602|Compound:kawain|FD-Score:6.55|P-value:5.95E-12 ID:SGTC_2796|Compound:7949634|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.06|P-value:1.34E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-2.99|P-value:9.41E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.32|P-value:3.59E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.63|P-value:8.62E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-3.03|P-value:8.37E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.27|P-value:3.54E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.99|P-value:1.78E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.32|P-value:3.96E-6 ID:SGTC_3254|Compound:9136651|FD-Score:4.19|P-value:7.14E-6 ID:SGTC_3292|Compound:9120825|FD-Score:4.98|P-value:1.28E-7

Top fitness defect scores for YLR176C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2594 a-mangostin 12.80 100.0 µM 3.74E-40 1 1.55E-37
2 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 7.51 100.0 µM 3.64E-15 2 2.96E-14
3 SGTC_2602 kawain 6.55 100.0 µM 5.95E-12 1 2.93E-11
4 SGTC_2409 alverine citrate 5.61 64.0 µM 3.20E-9 27 1.03E-8
5 SGTC_700 3453-2283 5.23 142.0 µM 3.11E-8 amide catabolism 6 8.63E-8
6 SGTC_2183 6420625 5.22 130.5 µM 3.16E-8 mitochondrial processes 27 8.76E-8
7 SGTC_1364 1653-0028 5.07 37.6 µM 7.57E-8 7 1.98E-7
8 SGTC_3292 9120825 4.98 59.8 µM 1.28E-7 6 3.24E-7
9 SGTC_2598 perillyl alcohol 4.67 100.0 µM 6.78E-7 15 1.53E-6
10 SGTC_2336 9001819 4.32 198.7 µM 3.82E-6 heme biosynthesis & mitochondrial translocase 40 7.72E-6
11 SGTC_2016 5121758 4.32 140.0 µM 3.90E-6 redox potentiating 39 7.87E-6
12 SGTC_3179 9107801 4.32 49.5 µM 3.96E-6 3 7.97E-6
13 SGTC_2412 st077135 4.23 33.4 µM 5.97E-6 19 1.17E-5
14 SGTC_3254 9136651 4.19 49.5 µM 7.14E-6 DNA damage response 19 1.38E-5
15 SGTC_2337 9009472 4.07 200.0 µM 1.27E-5 30 2.37E-5
16 SGTC_2798 7813637 4.06 45.5 µM 1.34E-5 28 2.50E-5
17 SGTC_3018 9082602 3.99 49.5 µM 1.78E-5 49 3.26E-5
18 SGTC_953 1188-0045 3.99 9.7 µM 1.82E-5 60S ribosome export 27 3.33E-5
19 SGTC_1507 4075-3230 3.82 155.0 µM 3.85E-5 11 6.68E-5
20 SGTC_1543 azetidyl-2-carboxylic acid 3.80 198.0 µM 4.26E-5 18 7.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 1.02E-12 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.107 4.34E-10 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.105 1.13E-9 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.102 3.75E-9 YGR031W IMO32 hom Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
0.101 5.12E-9 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.096 2.27E-8 YEL013W VAC8 hom Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
0.096 2.41E-8 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.094 5.41E-8 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.091 1.28E-7 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.088 3.06E-7 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
0.087 4.17E-7 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.087 5.02E-7 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.082 1.79E-6 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.082 1.80E-6 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.081 2.51E-6 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p