YLR177W_p

Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR177W / YLR177W

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.16|P-value:6.02E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.15|P-value:6.25E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.21|P-value:5.09E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.81|P-value:4.84E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.58|P-value:5.26E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.38|P-value:2.71E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.77|P-value:5.74E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.71|P-value:6.84E-7 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.33|P-value:3.28E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.28|P-value:3.63E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.29|P-value:3.74E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.52|P-value:1.58E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-5.75|P-value:1.65E-9 ID:SGTC_2784|Compound:7567673|FD-Score:-3.20|P-value:4.94E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.02|P-value:1.95E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.36|P-value:2.71E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.90|P-value:3.18E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.78|P-value:5.34E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.28|P-value:3.72E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.16|P-value:6.02E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.15|P-value:6.25E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.21|P-value:5.09E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.53|P-value:1.51E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.81|P-value:4.84E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.58|P-value:5.26E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.38|P-value:2.71E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.77|P-value:5.74E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.71|P-value:6.84E-7 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.33|P-value:3.28E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.28|P-value:3.63E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.29|P-value:3.74E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.52|P-value:1.58E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-5.75|P-value:1.65E-9 ID:SGTC_2784|Compound:7567673|FD-Score:-3.20|P-value:4.94E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.02|P-value:1.95E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.36|P-value:2.71E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.90|P-value:3.18E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.78|P-value:5.34E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.28|P-value:3.72E-4

Top fitness defect scores for YLR177W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1122 capsaicin 5.58 818.6 nM 5.26E-9 3 1.18E-8
2 SGTC_1314 1222-0010 4.71 41.1 µM 6.84E-7 4 1.22E-6
3 SGTC_2974 9094440 4.02 9.7 µM 1.95E-5 ergosterol biosynthesis 45 2.97E-5
4 SGTC_3201 9113999 3.90 49.5 µM 3.18E-5 37 4.71E-5
5 SGTC_656 4090-1979 3.81 187.0 µM 4.84E-5 22 7.05E-5
6 SGTC_3207 9114163 3.78 49.5 µM 5.34E-5 34 7.73E-5
7 SGTC_1305 1181-0477 3.77 144.0 µM 5.74E-5 17 8.29E-5
8 SGTC_1124 fisetin 3.53 1.2 µM 1.50E-4 49 2.07E-4
9 SGTC_531 3788-1495 3.53 174.0 µM 1.51E-4 unfolded protein response 29 2.09E-4
10 SGTC_2002 4023503 3.52 131.0 µM 1.58E-4 mitochondrial processes 54 2.17E-4
11 SGTC_1262 0737-0114 3.38 49.6 µM 2.71E-4 44 3.64E-4
12 SGTC_1505 k297-0037 3.33 20.6 µM 3.28E-4 38 4.37E-4
13 SGTC_248 streptozotocin 3.31 5.2 mM 3.53E-4 DNA damage response 35 4.68E-4
14 SGTC_1909 st060837 3.29 51.5 µM 3.74E-4 78 4.95E-4
15 SGTC_315 k915-0449 3.21 187.0 µM 5.09E-4 89 6.65E-4
16 SGTC_37 0566-0070 3.16 1.6 µM 6.02E-4 61 7.80E-4
17 SGTC_82 0054-0107 3.15 293.8 µM 6.25E-4 24 8.08E-4
18 SGTC_983 1491-0821 2.98 12.2 µM 0.00114 45 0.00144
19 SGTC_1626 st003712 2.97 1.8 µM 0.00119 70 0.00149
20 SGTC_2791 5663188 2.95 71.4 µM 0.00126 RPP1 & pyrimidine depletion 66 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.11E-17 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.132 1.35E-14 YPR117W_p YPR117W_p hom Putative protein of unknown function
0.131 2.73E-14 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.129 7.69E-14 YPL230W USV1 hom Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication
0.128 9.18E-14 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.121 1.84E-12 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.114 3.35E-11 YIR036C_p IRC24_p hom Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci
0.112 7.80E-11 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.112 8.15E-11 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.101 4.69E-9 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.100 6.02E-9 YML059C NTE1 hom Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
0.100 6.33E-9 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.099 7.89E-9 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.098 1.23E-8 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.097 1.78E-8 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control