Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR178C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.131 | 2.98E-14 | YNL332W | THI12 | hom | Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 |
0.118 | 5.91E-12 | YKL151C | YKL151C | hom | NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |
0.114 | 3.50E-11 | YMR075W | RCO1 | hom | Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p |
0.112 | 7.85E-11 | YMR095C | SNO1 | hom | Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase |
0.109 | 2.15E-10 | YKL168C | KKQ8 | hom | Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication |
0.105 | 1.25E-9 | YDR061W_p | YDR061W_p | hom | Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance |
0.102 | 2.74E-9 | YOL024W_p | YOL024W_p | hom | Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication |
0.093 | 6.25E-8 | YJL068C | YJL068C | hom | Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D |
0.091 | 1.33E-7 | YGL003C | CDH1 | hom | Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p |
0.090 | 1.63E-7 | YJR019C | TES1 | hom | Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids |
0.090 | 1.73E-7 | YOR163W | DDP1 | hom | Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress |
0.089 | 2.50E-7 | YPR152C | URN1 | hom | Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase |
0.089 | 2.57E-7 | YDL039C | PRM7 | hom | Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements |
0.084 | 1.21E-6 | YNL097C-B_p | YNL097C-B_p | hom | Putative protein of unknown function |
0.082 | 1.73E-6 | YOR037W | CYC2 | hom | Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) |