HIPHOP chemogenomics database

YLR178C / TFS1

Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR178C / TFS1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR178C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2622	2-methoxyxanthone	7.35	59.9 µM	5.79E-18		3	1.02E-13
2	SGTC_1916	st067606	4.09	49.2 µM	9.60E-7		35	2.19E-5
3	SGTC_2402	5553605	3.61	200.0 µM	1.30E-5		44	1.53E-4
4	SGTC_472	calcifediol	3.42	10.0 µM	3.30E-5		15	3.08E-4
5	SGTC_1204	4049-0315	3.42	18.3 µM	3.36E-5		53	3.12E-4
6	SGTC_734	2023-0417	3.33	80.0 µM	5.25E-5	ergosterol biosynthesis	39	4.36E-4
7	SGTC_796	1234-0020	3.26	70.7 µM	7.28E-5	SWF1 & branched chain AA biosynthesis	47	5.58E-4
8	SGTC_871	0574-0004	3.21	149.0 µM	9.10E-5		79	6.59E-4
9	SGTC_343	4130-2827	3.20	29.8 µM	9.49E-5		64	6.80E-4
10	SGTC_2125	5246583	3.17	200.0 µM	1.10E-4	tubulin folding & SWR complex	87	7.59E-4
11	SGTC_2202	7226349	2.97	200.0 µM	2.70E-4		35	0.00149
12	SGTC_3354	9151612	2.91	71.4 µM	3.46E-4		57	0.00180
13	SGTC_2602	kawain	2.85	100.0 µM	4.41E-4		89	0.00216
14	SGTC_1100	amiodarone	2.84	5.1 µM	4.70E-4		58	0.00227
15	SGTC_3316	9136639	2.81	10.6 µM	5.30E-4		63	0.00248
16	SGTC_1920	st075728	2.78	45.7 µM	5.87E-4		90	0.00268
17	SGTC_1055	3448-0672	2.78	86.0 µM	5.99E-4		100	0.00272
18	SGTC_882	0843-0131	2.77	351.0 µM	6.27E-4		81	0.00281
19	SGTC_3084	9116877	2.77	49.5 µM	6.30E-4		35	0.00282
20	SGTC_1189	1431-2119	2.75	7.3 µM	6.74E-4		112	0.00297

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.131	2.98E-14	YNL332W	THI12	hom	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.118	5.91E-12	YKL151C	YKL151C	hom	NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.114	3.50E-11	YMR075W	RCO1	hom	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.112	7.85E-11	YMR095C	SNO1	hom	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.109	2.15E-10	YKL168C	KKQ8	hom	Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.105	1.25E-9	YDR061W_p	YDR061W_p	hom	Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.102	2.74E-9	YOL024W_p	YOL024W_p	hom	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.093	6.25E-8	YJL068C	YJL068C	hom	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.091	1.33E-7	YGL003C	CDH1	hom	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
0.090	1.63E-7	YJR019C	TES1	hom	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.090	1.73E-7	YOR163W	DDP1	hom	Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.089	2.50E-7	YPR152C	URN1	hom	Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
0.089	2.57E-7	YDL039C	PRM7	hom	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.084	1.21E-6	YNL097C-B_p	YNL097C-B_p	hom	Putative protein of unknown function
0.082	1.73E-6	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)