YLR183C / TOS4

Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR183C / TOS4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.55|P-value:3.13E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.12|P-value:3.19E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.52|P-value:3.44E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.25|P-value:7.85E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.60|P-value:2.37E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.53|P-value:3.02E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.28|P-value:8.05E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.33|P-value:1.30E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.48|P-value:3.68E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.60|P-value:2.67E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.07|P-value:3.91E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.81|P-value:1.08E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.56|P-value:2.68E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.26|P-value:7.71E-4 ID:SGTC_1591|Compound:genipin|FD-Score:4.16|P-value:2.66E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.35|P-value:5.65E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.19|P-value:2.36E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.88|P-value:8.09E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.59|P-value:2.76E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.31|P-value:6.55E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.32|P-value:6.87E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-4.19|P-value:2.69E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.42|P-value:4.45E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.32|P-value:1.36E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-3.76|P-value:1.45E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.64|P-value:2.29E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.35|P-value:6.19E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.43|P-value:8.58E-6 ID:SGTC_3137|Compound:9097352|FD-Score:3.86|P-value:8.87E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.43|P-value:6.81E-8 ID:SGTC_3215|Compound:9129942|FD-Score:-4.26|P-value:2.02E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.84|P-value:9.78E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.55|P-value:3.13E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.12|P-value:3.19E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.52|P-value:3.44E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.25|P-value:7.85E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.60|P-value:2.37E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.53|P-value:3.02E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.28|P-value:8.05E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.33|P-value:1.30E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.48|P-value:3.68E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.60|P-value:2.67E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.07|P-value:3.91E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.81|P-value:1.08E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.56|P-value:2.68E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.26|P-value:7.71E-4 ID:SGTC_1591|Compound:genipin|FD-Score:4.16|P-value:2.66E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.35|P-value:5.65E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.19|P-value:2.36E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.88|P-value:8.09E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.59|P-value:2.76E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.31|P-value:6.55E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.32|P-value:6.87E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-4.19|P-value:2.69E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.42|P-value:4.45E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.32|P-value:1.36E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-3.76|P-value:1.45E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.64|P-value:2.29E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.35|P-value:6.19E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.43|P-value:8.58E-6 ID:SGTC_3137|Compound:9097352|FD-Score:3.86|P-value:8.87E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.43|P-value:6.81E-8 ID:SGTC_3215|Compound:9129942|FD-Score:-4.26|P-value:2.02E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.84|P-value:9.78E-5

Top fitness defect scores for YLR183C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3141 9094609 5.43 49.5 µM 6.81E-8 iron homeostasis 11 2.76E-8
2 SGTC_2987 9018338 4.43 71.4 µM 8.58E-6 RPP1 & pyrimidine depletion 7 4.73E-6
3 SGTC_2597 laccaic acid a 4.35 100.0 µM 1.19E-5 27 6.68E-6
4 SGTC_1197 1601-0112 4.33 267.0 µM 1.30E-5 11 7.35E-6
5 SGTC_2842 9000675 4.32 19.5 µM 1.36E-5 17 7.73E-6
6 SGTC_2079 5212404 4.19 121.0 µM 2.36E-5 10 1.39E-5
7 SGTC_1591 genipin 4.16 88.4 µM 2.66E-5 mitochondrial processes 9 1.57E-5
8 SGTC_64 000l-0018 4.12 272.1 µM 3.19E-5 ubiquinone biosynthesis & proteasome 139 1.91E-5
9 SGTC_1354 1498-1681 4.07 81.0 µM 3.91E-5 17 2.37E-5
10 SGTC_2094 5332512 3.88 191.7 µM 8.09E-5 23 5.12E-5
11 SGTC_3137 9097352 3.86 49.5 µM 8.87E-5 43 5.65E-5
12 SGTC_3302 9125395 3.84 16.4 µM 9.78E-5 13 6.27E-5
13 SGTC_1578 josamycin 3.81 24.2 µM 1.08E-4 15 6.99E-5
14 SGTC_2280 7785178 3.79 200.0 µM 1.18E-4 12 7.64E-5
15 SGTC_569 4130-2812 3.66 160.0 µM 1.89E-4 amide catabolism 13 1.26E-4
16 SGTC_522 1273-0010 3.60 11.6 µM 2.37E-4 60S ribosome export 31 1.60E-4
17 SGTC_1582 3',3',6'-trihydroxyflavone 3.56 74.0 µM 2.68E-4 14 1.82E-4
18 SGTC_1160 4092-0570 3.53 10.5 µM 3.02E-4 plasma membrane duress 53 2.07E-4
19 SGTC_1306 1185-0270 3.48 9.0 µM 3.68E-4 Golgi 65 2.55E-4
20 SGTC_2614 arthonioic acid 3.42 13.4 µM 4.45E-4 35 3.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 5.79E-8 YGR014W MSB2 hom Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.085 9.17E-7 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.084 1.04E-6 YGL044C RNA15 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.082 1.77E-6 YHR007C-A_p YHR007C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.081 2.69E-6 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.080 3.19E-6 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.080 3.51E-6 YKR037C SPC34 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.080 3.56E-6 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.079 4.51E-6 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.079 4.86E-6 YKR050W TRK2 hom Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
0.078 6.06E-6 YFR016C YFR016C hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
0.077 8.91E-6 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.076 1.05E-5 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.075 1.30E-5 YPL080C_d YPL080C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.074 1.86E-5 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress