YLR184W_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR184W / YLR184W

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:3.22|P-value:7.05E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.36|P-value:4.33E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:4.00|P-value:3.85E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.39|P-value:3.86E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.38|P-value:4.08E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.99|P-value:4.12E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.16|P-value:8.60E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:3.65E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.11|P-value:9.93E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.22|P-value:7.08E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.26|P-value:6.02E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.89|P-value:6.01E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.28|P-value:5.76E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.31|P-value:9.11E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:5.20|P-value:1.60E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.61|P-value:1.78E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.36|P-value:8.62E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.71|P-value:1.80E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.11|P-value:2.52E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.33|P-value:4.83E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:6.22|P-value:5.40E-10 ID:SGTC_1931|Compound:st074438|FD-Score:3.15|P-value:8.85E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.94|P-value:5.94E-7 ID:SGTC_2017|Compound:5132927|FD-Score:5.15|P-value:2.07E-7 ID:SGTC_2099|Compound:5377090|FD-Score:4.62|P-value:2.69E-6 ID:SGTC_2134|Compound:5324836|FD-Score:3.14|P-value:9.22E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.70|P-value:1.28E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.64|P-value:2.96E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:7.05|P-value:2.59E-12 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.74|P-value:1.51E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-6.27|P-value:1.12E-9 ID:SGTC_2646|Compound:retinol|FD-Score:3.26|P-value:6.15E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.35|P-value:8.84E-6 ID:SGTC_2821|Compound:7996764|FD-Score:5.28|P-value:1.07E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-4.40|P-value:1.51E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-4.77|P-value:3.00E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-4.17|P-value:3.92E-5 ID:SGTC_2846|Compound:9008642|FD-Score:-3.98|P-value:8.41E-5 ID:SGTC_2871|Compound:9038510|FD-Score:4.57|P-value:3.39E-6 ID:SGTC_2900|Compound:5328528|FD-Score:4.38|P-value:7.99E-6 ID:SGTC_2909|Compound:7941780|FD-Score:4.44|P-value:6.11E-6 ID:SGTC_2964|Compound:9083345|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.13|P-value:9.53E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.26|P-value:6.16E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.66|P-value:2.78E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-6.83|P-value:3.50E-11 ID:SGTC_3210|Compound:9128157|FD-Score:4.21|P-value:1.68E-5 ID:SGTC_3211|Compound:9128781|FD-Score:6.70|P-value:2.65E-11 ID:SGTC_3235|Compound:9132602|FD-Score:3.50|P-value:2.60E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.35|P-value:4.46E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.22|P-value:7.05E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.36|P-value:4.33E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:4.00|P-value:3.85E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.39|P-value:3.86E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.38|P-value:4.08E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.99|P-value:4.12E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.16|P-value:8.60E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:3.65E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.11|P-value:9.93E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.22|P-value:7.08E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.26|P-value:6.02E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.89|P-value:6.01E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.28|P-value:5.76E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.31|P-value:9.11E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:5.20|P-value:1.60E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.61|P-value:1.78E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.36|P-value:8.62E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.71|P-value:1.80E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.11|P-value:2.52E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.33|P-value:4.83E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:6.22|P-value:5.40E-10 ID:SGTC_1931|Compound:st074438|FD-Score:3.15|P-value:8.85E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.94|P-value:5.94E-7 ID:SGTC_2017|Compound:5132927|FD-Score:5.15|P-value:2.07E-7 ID:SGTC_2099|Compound:5377090|FD-Score:4.62|P-value:2.69E-6 ID:SGTC_2134|Compound:5324836|FD-Score:3.14|P-value:9.22E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.70|P-value:1.28E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.64|P-value:2.96E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:7.05|P-value:2.59E-12 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.74|P-value:1.51E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-6.27|P-value:1.12E-9 ID:SGTC_2646|Compound:retinol|FD-Score:3.26|P-value:6.15E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.35|P-value:8.84E-6 ID:SGTC_2821|Compound:7996764|FD-Score:5.28|P-value:1.07E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-4.40|P-value:1.51E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-4.77|P-value:3.00E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-4.17|P-value:3.92E-5 ID:SGTC_2846|Compound:9008642|FD-Score:-3.98|P-value:8.41E-5 ID:SGTC_2871|Compound:9038510|FD-Score:4.57|P-value:3.39E-6 ID:SGTC_2900|Compound:5328528|FD-Score:4.38|P-value:7.99E-6 ID:SGTC_2909|Compound:7941780|FD-Score:4.44|P-value:6.11E-6 ID:SGTC_2964|Compound:9083345|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.13|P-value:9.53E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.26|P-value:6.16E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.66|P-value:2.78E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-6.83|P-value:3.50E-11 ID:SGTC_3210|Compound:9128157|FD-Score:4.21|P-value:1.68E-5 ID:SGTC_3211|Compound:9128781|FD-Score:6.70|P-value:2.65E-11 ID:SGTC_3235|Compound:9132602|FD-Score:3.50|P-value:2.60E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.35|P-value:4.46E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.38|P-value:4.10E-4

Top fitness defect scores for YLR184W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2536 dehydroabietamide 7.05 32.0 µM 2.59E-12 1 8.80E-13
2 SGTC_3211 9128781 6.70 49.5 µM 2.65E-11 16 1.03E-11
3 SGTC_1584 6-fluoro-dl-tryptophan 6.22 90.0 µM 5.40E-10 mitochondrial processes 1 2.47E-10
4 SGTC_2821 7996764 5.28 71.4 µM 1.07E-7 15 6.49E-8
5 SGTC_1120 ficusin 5.20 1.8 µM 1.60E-7 6 9.89E-8
6 SGTC_2017 5132927 5.15 60.6 µM 2.07E-7 9 1.29E-7
7 SGTC_2013 4024628 4.94 200.0 µM 5.94E-7 24 3.93E-7
8 SGTC_2630 antimycin a 4.74 100.0 µM 1.51E-6 mitochondrial processes 20 1.04E-6
9 SGTC_1453 4237-0541 4.71 195.0 µM 1.80E-6 heme biosynthesis & mitochondrial translocase 15 1.26E-6
10 SGTC_2099 5377090 4.62 177.4 µM 2.69E-6 10 1.92E-6
11 SGTC_2871 9038510 4.57 13.0 µM 3.39E-6 10 2.44E-6
12 SGTC_2909 7941780 4.44 10.5 µM 6.11E-6 11 4.53E-6
13 SGTC_2900 5328528 4.38 85.3 µM 7.99E-6 Golgi 21 6.01E-6
14 SGTC_1184 1269-1718 4.36 139.0 µM 8.62E-6 20 6.51E-6
15 SGTC_2688 kanamycin b 4.35 96.7 µM 8.84E-6 calcium & mitochondrial duress 316 6.68E-6
16 SGTC_3210 9128157 4.21 49.5 µM 1.68E-5 42 1.30E-5
17 SGTC_1537 2',6'-dihydroxyflavanone 4.11 78.0 µM 2.52E-5 15 2.00E-5
18 SGTC_209 4077-0173 4.00 175.6 µM 3.85E-5 9 3.12E-5
19 SGTC_342 k048-0088 3.99 23.3 µM 4.12E-5 RSC & ERG11 16 3.34E-5
20 SGTC_755 1995-0008 3.89 37.3 µM 6.01E-5 21 4.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.71E-12 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.118 7.69E-12 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.117 9.13E-12 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.116 1.68E-11 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.112 7.64E-11 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.109 2.32E-10 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.103 1.88E-9 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.100 5.68E-9 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.099 8.89E-9 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.096 2.59E-8 YMR207C HFA1 hom Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.094 4.54E-8 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.094 5.37E-8 YLR180W SAM1 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
0.093 6.10E-8 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.093 6.90E-8 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.091 1.50E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine