YLR185W / RPL37A

Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR185W / RPL37A

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.89|P-value:3.66E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:4.48|P-value:2.75E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.38|P-value:3.61E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.21|P-value:6.51E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.07|P-value:8.95E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:5.33|P-value:3.22E-8 ID:SGTC_850|Compound:0388-0143|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.10|P-value:9.75E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.37|P-value:3.09E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.68|P-value:9.46E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.47|P-value:2.60E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.22|P-value:5.25E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.60|P-value:1.26E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.72|P-value:7.90E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.13|P-value:7.36E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.78|P-value:6.33E-5 ID:SGTC_1650|Compound:st011916|FD-Score:4.34|P-value:5.38E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.24|P-value:6.00E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.46|P-value:2.23E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:9.78|P-value:2.36E-23 ID:SGTC_1940|Compound:st075990|FD-Score:3.12|P-value:7.47E-4 ID:SGTC_1943|Compound:st076331|FD-Score:4.44|P-value:3.35E-6 ID:SGTC_1947|Compound:st076332|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_1949|Compound:st076024|FD-Score:5.26|P-value:4.79E-8 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.26|P-value:7.56E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.29|P-value:4.11E-8 ID:SGTC_2987|Compound:9018338|FD-Score:3.21|P-value:5.52E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.09|P-value:8.35E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.20|P-value:1.27E-5 ID:SGTC_3086|Compound:9117350|FD-Score:-3.32|P-value:4.50E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.70|P-value:1.03E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.69|P-value:1.11E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.13|P-value:7.29E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.35|P-value:3.37E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.90|P-value:3.74E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.89|P-value:3.66E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:4.48|P-value:2.75E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.38|P-value:3.61E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.21|P-value:6.51E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.07|P-value:8.95E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:5.33|P-value:3.22E-8 ID:SGTC_850|Compound:0388-0143|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.10|P-value:9.75E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.37|P-value:3.09E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.68|P-value:9.46E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.47|P-value:2.60E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.22|P-value:5.25E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.60|P-value:1.26E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.72|P-value:7.90E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.13|P-value:7.36E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.78|P-value:6.33E-5 ID:SGTC_1650|Compound:st011916|FD-Score:4.34|P-value:5.38E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.24|P-value:6.00E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.46|P-value:2.23E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:9.78|P-value:2.36E-23 ID:SGTC_1940|Compound:st075990|FD-Score:3.12|P-value:7.47E-4 ID:SGTC_1943|Compound:st076331|FD-Score:4.44|P-value:3.35E-6 ID:SGTC_1947|Compound:st076332|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_1949|Compound:st076024|FD-Score:5.26|P-value:4.79E-8 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.26|P-value:7.56E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.29|P-value:4.11E-8 ID:SGTC_2987|Compound:9018338|FD-Score:3.21|P-value:5.52E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.09|P-value:8.35E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.20|P-value:1.27E-5 ID:SGTC_3086|Compound:9117350|FD-Score:-3.32|P-value:4.50E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.70|P-value:1.03E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.69|P-value:1.11E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.13|P-value:7.29E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.35|P-value:3.37E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.90|P-value:3.74E-5

Top fitness defect scores for YLR185W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 9.78 70.1 µM 2.36E-23 1 7.02E-23
2 SGTC_751 0833-0568 5.33 350.0 µM 3.22E-8 4 4.79E-8
3 SGTC_2688 kanamycin b 5.29 96.7 µM 4.11E-8 calcium & mitochondrial duress 221 6.08E-8
4 SGTC_1949 st076024 5.26 69.1 µM 4.79E-8 8 7.06E-8
5 SGTC_118 0083-0097 4.89 135.3 µM 3.66E-7 translation 66 5.17E-7
6 SGTC_341 1486-1430 4.48 230.0 µM 2.75E-6 13 3.72E-6
7 SGTC_1943 st076331 4.44 65.2 µM 3.35E-6 11 4.51E-6
8 SGTC_1650 st011916 4.34 45.8 µM 5.38E-6 7 7.17E-6
9 SGTC_2635 hydroquinidine 4.26 100.0 µM 7.56E-6 17 1.00E-5
10 SGTC_3325 9138760 3.90 55.2 µM 3.74E-5 Golgi 29 4.77E-5
11 SGTC_1646 st011709 3.78 75.6 µM 6.33E-5 15 7.99E-5
12 SGTC_1289 0976-0073 3.72 69.1 µM 7.90E-5 18 9.93E-5
13 SGTC_980 1473-0395 3.68 201.0 µM 9.46E-5 16 1.18E-4
14 SGTC_750 4073-0104 3.66 132.0 µM 1.01E-4 15 1.26E-4
15 SGTC_1225 1216-0074 3.60 20.6 µM 1.26E-4 35 1.57E-4
16 SGTC_1947 st076332 3.52 61.6 µM 1.77E-4 20 2.19E-4
17 SGTC_1221 2958-7315 3.52 257.0 µM 1.78E-4 26 2.19E-4
18 SGTC_1819 st053448 3.46 58.6 µM 2.23E-4 amide catabolism 35 2.74E-4
19 SGTC_886 0866-0150 3.37 153.0 µM 3.09E-4 38 3.76E-4
20 SGTC_3302 9125395 3.35 16.4 µM 3.37E-4 33 4.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.26E-22 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.150 2.27E-18 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.142 1.60E-16 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.139 6.88E-16 YGL078C DBP3 hom RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
0.134 5.92E-15 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.133 1.15E-14 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.133 1.30E-14 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.124 4.95E-13 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.116 1.79E-11 YJL177W RPL17B hom Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication
0.115 2.51E-11 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.113 4.97E-11 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.110 1.98E-10 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.106 7.40E-10 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.105 9.51E-10 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.103 2.35E-9 YDR161W_p YDR161W_p hom Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)