YLR187W / SKG3

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR187W / SKG3

Click on Significant Values for Screen Details

Top fitness defect scores for YLR187W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_737 1950-0117 5.06 57.9 µM 1.54E-7 8 2.13E-7
2 SGTC_1909 st060837 4.94 51.5 µM 2.90E-7 30 3.94E-7
3 SGTC_1437 4092-1038 4.67 11.6 µM 1.15E-6 8 1.51E-6
4 SGTC_381 3461-2219 4.64 42.7 µM 1.30E-6 copper-dependent oxidative stress 12 1.71E-6
5 SGTC_2621 lithochol-11-enic acid 4.58 100.0 µM 1.78E-6 11 2.32E-6
6 SGTC_2310 7668677 4.55 200.0 µM 2.10E-6 16 2.73E-6
7 SGTC_2049 5262831 4.33 67.2 µM 5.82E-6 20 7.36E-6
8 SGTC_3066 9117245 4.21 49.5 µM 1.02E-5 11 1.28E-5
9 SGTC_2164 5685496 4.14 200.0 µM 1.38E-5 21 1.71E-5
10 SGTC_638 3970-0837 4.10 4.1 µM 1.71E-5 35 2.11E-5
11 SGTC_2416 tofa 4.04 880.0 nM 2.22E-5 sphingolipid biosynthesis & PDR1 47 2.72E-5
12 SGTC_776 4476-4378 3.93 112.0 µM 3.58E-5 ERG2 19 4.33E-5
13 SGTC_713 1488-1073 3.71 324.0 µM 8.91E-5 ERG2 14 1.06E-4
14 SGTC_2014 4013930 3.68 200.0 µM 9.72E-5 48 1.15E-4
15 SGTC_2592 piperlongumine 3.65 83.3 µM 1.09E-4 TSC3-RPN4 54 1.29E-4
16 SGTC_715 0868-0130 3.63 184.0 µM 1.20E-4 12 1.42E-4
17 SGTC_2299 7976368 3.60 114.9 µM 1.37E-4 42 1.61E-4
18 SGTC_316 k060-0003 3.59 58.6 µM 1.41E-4 24 1.65E-4
19 SGTC_326 k292-0812 3.57 17.5 µM 1.50E-4 11 1.75E-4
20 SGTC_953 1188-0045 3.51 9.7 µM 1.90E-4 60S ribosome export 39 2.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.65E-16 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 4.10E-15 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.120 3.27E-12 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.116 1.86E-11 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.116 1.94E-11 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.114 3.50E-11 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.114 3.59E-11 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 4.32E-10 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.106 8.65E-10 YLR254C NDL1 hom Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
0.102 2.85E-9 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.102 3.52E-9 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.101 4.94E-9 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.099 8.02E-9 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.099 8.39E-9 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.099 8.89E-9 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress