YLR188W / MDL1

Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR188W / MDL1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:12.90|P-value:6.68E-37 ID:SGTC_141|Compound:0443-0274|FD-Score:8.22|P-value:3.80E-16 ID:SGTC_429|Compound:1112-0049|FD-Score:3.55|P-value:2.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.60|P-value:3.41E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:4.07|P-value:3.45E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.43|P-value:4.00E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.22|P-value:5.67E-10 ID:SGTC_815|Compound:1582-0027|FD-Score:3.83|P-value:9.09E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.39|P-value:4.57E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-4.34|P-value:9.35E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.51|P-value:2.69E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.22|P-value:1.85E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.57|P-value:2.51E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.26|P-value:6.37E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.19|P-value:9.07E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.05|P-value:3.69E-5 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.19|P-value:2.04E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.20|P-value:8.73E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.14|P-value:2.57E-5 ID:SGTC_1964|Compound:st076914|FD-Score:4.12|P-value:2.84E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.22|P-value:1.82E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.20|P-value:1.99E-5 ID:SGTC_2367|Compound:9070478|FD-Score:5.27|P-value:1.22E-7 ID:SGTC_2368|Compound:9071271|FD-Score:5.79|P-value:7.10E-9 ID:SGTC_2425|Compound:5628681|FD-Score:3.48|P-value:3.32E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.83|P-value:7.96E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.50|P-value:3.08E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.39|P-value:4.67E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-4.09|P-value:2.75E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.62|P-value:3.14E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.45|P-value:3.76E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.59|P-value:2.25E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.31|P-value:5.38E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.19|P-value:9.09E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.90|P-value:6.90E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.17|P-value:9.93E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.89|P-value:8.33E-7 ID:SGTC_3062|Compound:9077494|FD-Score:3.80|P-value:1.00E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:12.90|P-value:6.68E-37 ID:SGTC_141|Compound:0443-0274|FD-Score:8.22|P-value:3.80E-16 ID:SGTC_429|Compound:1112-0049|FD-Score:3.55|P-value:2.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.60|P-value:3.41E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:4.07|P-value:3.45E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.43|P-value:4.00E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.22|P-value:5.67E-10 ID:SGTC_815|Compound:1582-0027|FD-Score:3.83|P-value:9.09E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.39|P-value:4.57E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-4.34|P-value:9.35E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.51|P-value:2.69E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.22|P-value:1.85E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.57|P-value:2.51E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.26|P-value:6.37E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.19|P-value:9.07E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.05|P-value:3.69E-5 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.19|P-value:2.04E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.20|P-value:8.73E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.14|P-value:2.57E-5 ID:SGTC_1964|Compound:st076914|FD-Score:4.12|P-value:2.84E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.22|P-value:1.82E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.20|P-value:1.99E-5 ID:SGTC_2367|Compound:9070478|FD-Score:5.27|P-value:1.22E-7 ID:SGTC_2368|Compound:9071271|FD-Score:5.79|P-value:7.10E-9 ID:SGTC_2425|Compound:5628681|FD-Score:3.48|P-value:3.32E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.83|P-value:7.96E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.50|P-value:3.08E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.39|P-value:4.67E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-4.09|P-value:2.75E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.62|P-value:3.14E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.45|P-value:3.76E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.59|P-value:2.25E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.31|P-value:5.38E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.19|P-value:9.09E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.90|P-value:6.90E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.17|P-value:9.93E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.89|P-value:8.33E-7 ID:SGTC_3062|Compound:9077494|FD-Score:3.80|P-value:1.00E-4

Top fitness defect scores for YLR188W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_116 0155-0182 12.90 31.8 µM 6.68E-37 mitochondrial response to ROS 4 2.82E-38
2 SGTC_141 0443-0274 8.22 32.3 µM 3.80E-16 mitochondrial response to ROS 10 9.87E-17
3 SGTC_778 3456-2434 6.22 196.0 µM 5.67E-10 mitochondrial response to ROS 23 2.54E-10
4 SGTC_2368 9071271 5.79 200.0 µM 7.10E-9 6 3.50E-9
5 SGTC_1098 clofazimine 5.57 15.1 µM 2.51E-8 heme biosynthesis & mitochondrial translocase 6 1.30E-8
6 SGTC_2367 9070478 5.27 135.4 µM 1.22E-7 cell wall 16 6.69E-8
7 SGTC_2965 9082772 4.89 38.6 µM 8.33E-7 mitochondrial response to ROS 21 4.94E-7
8 SGTC_2755 lomerizine 4.62 42.7 µM 3.14E-6 16 1.96E-6
9 SGTC_749 1000-0129 4.60 128.0 µM 3.41E-6 amide catabolism 8 2.14E-6
10 SGTC_2359 9039622 4.22 200.0 µM 1.82E-5 endomembrane recycling 19 1.22E-5
11 SGTC_1075 aripiprazole 4.22 15.2 µM 1.85E-5 22 1.24E-5
12 SGTC_2364 9055074 4.20 200.0 µM 1.99E-5 16 1.33E-5
13 SGTC_1549 4'-methoxyflavonol 4.19 74.6 µM 2.04E-5 6 1.37E-5
14 SGTC_1913 st060213 4.14 96.1 µM 2.57E-5 26 1.74E-5
15 SGTC_1964 st076914 4.12 61.0 µM 2.84E-5 RPP1 & pyrimidine depletion 16 1.93E-5
16 SGTC_751 0833-0568 4.07 350.0 µM 3.45E-5 18 2.36E-5
17 SGTC_1353 1498-1206 4.05 8.1 µM 3.69E-5 mitochondrial response to ROS 50 2.53E-5
18 SGTC_2925 9010536 3.90 32.5 µM 6.90E-5 azole & statin 52 4.85E-5
19 SGTC_815 1582-0027 3.83 36.9 µM 9.09E-5 31 6.46E-5
20 SGTC_3062 9077494 3.80 49.5 µM 1.00E-4 mitochondrial response to ROS 39 7.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 3.60E-55 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.226 5.96E-40 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.210 1.24E-34 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.174 4.15E-24 YOR211C MGM1 hom Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
0.167 1.88E-22 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.148 7.52E-18 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.146 1.81E-17 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.146 2.21E-17 YGR270W YTA7 hom Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
0.145 3.42E-17 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.141 2.76E-16 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.133 1.08E-14 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.127 1.39E-13 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.121 2.16E-12 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.117 1.15E-11 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.115 2.13E-11 YHR100C GEP4 hom Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT