YLR190W / MMR1

Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR190W / MMR1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.09|P-value:1.66E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.89|P-value:3.93E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.31|P-value:3.72E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:5.81|P-value:2.60E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:4.23|P-value:9.11E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:5.27|P-value:5.39E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:3.27|P-value:4.22E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.06|P-value:1.92E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:3.20|P-value:5.43E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.28|P-value:4.17E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.92|P-value:3.49E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.67|P-value:9.59E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.61|P-value:1.19E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.04|P-value:5.09E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.56|P-value:1.46E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.90|P-value:3.71E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.31|P-value:7.70E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.88|P-value:1.22E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-4.39|P-value:1.15E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.22|P-value:9.76E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.75|P-value:6.90E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:10.40|P-value:1.35E-25 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.38|P-value:5.98E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.52|P-value:3.78E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.96|P-value:1.01E-9 ID:SGTC_1847|Compound:st056231|FD-Score:3.05|P-value:9.18E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.41|P-value:1.06E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.12|P-value:7.24E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.72|P-value:1.78E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.59|P-value:2.86E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.31|P-value:7.71E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.80|P-value:5.76E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.40|P-value:1.10E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.62|P-value:7.60E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-5.91|P-value:4.96E-9 ID:SGTC_2696|Compound:st077691|FD-Score:5.00|P-value:2.26E-7 ID:SGTC_2713|Compound:st079149|FD-Score:3.35|P-value:3.25E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.24|P-value:4.68E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.91|P-value:8.59E-5 ID:SGTC_2989|Compound:9073649|FD-Score:9.46|P-value:1.72E-21 ID:SGTC_2990|Compound:9074105|FD-Score:-3.81|P-value:1.24E-4 ID:SGTC_2993|Compound:9054257|FD-Score:9.68|P-value:2.00E-22 ID:SGTC_2994|Compound:9053520|FD-Score:4.15|P-value:1.29E-5 ID:SGTC_2995|Compound:9067767|FD-Score:4.73|P-value:8.98E-7 ID:SGTC_3012|Compound:9080433|FD-Score:3.35|P-value:3.25E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.40|P-value:5.70E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.36|P-value:1.04E-7 ID:SGTC_3307|Compound:9126885|FD-Score:3.22|P-value:5.06E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.32|P-value:3.62E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.32|P-value:3.51E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.09|P-value:1.66E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.89|P-value:3.93E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.31|P-value:3.72E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:5.81|P-value:2.60E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:4.23|P-value:9.11E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:5.27|P-value:5.39E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:3.27|P-value:4.22E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.06|P-value:1.92E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:3.20|P-value:5.43E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.28|P-value:4.17E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.92|P-value:3.49E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.67|P-value:9.59E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.61|P-value:1.19E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.04|P-value:5.09E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.56|P-value:1.46E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.90|P-value:3.71E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.31|P-value:7.70E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.88|P-value:1.22E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-4.39|P-value:1.15E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.22|P-value:9.76E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.75|P-value:6.90E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:10.40|P-value:1.35E-25 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.38|P-value:5.98E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.52|P-value:3.78E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.96|P-value:1.01E-9 ID:SGTC_1847|Compound:st056231|FD-Score:3.05|P-value:9.18E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.41|P-value:1.06E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.12|P-value:7.24E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.72|P-value:1.78E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.59|P-value:2.86E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.31|P-value:7.71E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.80|P-value:5.76E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.40|P-value:1.10E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.62|P-value:7.60E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-5.91|P-value:4.96E-9 ID:SGTC_2696|Compound:st077691|FD-Score:5.00|P-value:2.26E-7 ID:SGTC_2713|Compound:st079149|FD-Score:3.35|P-value:3.25E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.24|P-value:4.68E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.91|P-value:8.59E-5 ID:SGTC_2989|Compound:9073649|FD-Score:9.46|P-value:1.72E-21 ID:SGTC_2990|Compound:9074105|FD-Score:-3.81|P-value:1.24E-4 ID:SGTC_2993|Compound:9054257|FD-Score:9.68|P-value:2.00E-22 ID:SGTC_2994|Compound:9053520|FD-Score:4.15|P-value:1.29E-5 ID:SGTC_2995|Compound:9067767|FD-Score:4.73|P-value:8.98E-7 ID:SGTC_3012|Compound:9080433|FD-Score:3.35|P-value:3.25E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.40|P-value:5.70E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.36|P-value:1.04E-7 ID:SGTC_3307|Compound:9126885|FD-Score:3.22|P-value:5.06E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.32|P-value:3.62E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.32|P-value:3.51E-4

Top fitness defect scores for YLR190W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1306 1185-0270 10.40 9.0 µM 1.35E-25 Golgi 10 1.10E-25
2 SGTC_2993 9054257 9.68 71.4 µM 2.00E-22 fatty acid desaturase (OLE1) 7 1.79E-22
3 SGTC_2989 9073649 9.46 71.4 µM 1.72E-21 1 1.59E-21
4 SGTC_1730 st033808 5.96 45.1 µM 1.01E-9 6 1.23E-9
5 SGTC_193 1273-0060 5.81 1.6 µM 2.60E-9 ergosterol biosynthesis 1 3.20E-9
6 SGTC_2533 agelasine 5.62 13.7 µM 7.60E-9 ERG2 14 9.44E-9
7 SGTC_234 nsc-17383 5.27 10.7 µM 5.39E-8 ERG2 13 6.76E-8
8 SGTC_2696 st077691 5.00 74.3 µM 2.26E-7 14 2.86E-7
9 SGTC_1116 jasmonic acid 4.90 1.6 µM 3.71E-7 6 4.69E-7
10 SGTC_2995 9067767 4.73 71.4 µM 8.98E-7 14 1.14E-6
11 SGTC_227 fluconazole 4.23 33.5 µM 9.11E-6 azole & statin 71 1.16E-5
12 SGTC_1261 0712-0010 4.22 12.7 µM 9.76E-6 RNA processing & uracil transport 17 1.24E-5
13 SGTC_2994 9053520 4.15 71.4 µM 1.29E-5 RPP1 & pyrimidine depletion 20 1.64E-5
14 SGTC_64 000l-0018 4.09 272.1 µM 1.66E-5 ubiquinone biosynthesis & proteasome 141 2.12E-5
15 SGTC_637 1181-0519 4.06 7.3 µM 1.92E-5 fatty acid desaturase (OLE1) 95 2.44E-5
16 SGTC_807 1315-0151 3.92 48.0 µM 3.49E-5 29 4.44E-5
17 SGTC_148 3253-0744 3.89 288.0 µM 3.93E-5 18 4.99E-5
18 SGTC_2406 ethylparaben 3.80 405.7 µM 5.76E-5 47 7.32E-5
19 SGTC_1273 0849-0096 3.75 14.1 µM 6.90E-5 RPP1 & pyrimidine depletion 28 8.77E-5
20 SGTC_813 k007-0158 3.67 173.0 µM 9.59E-5 fatty acid desaturase (OLE1) 57 1.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.15E-15 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.132 1.50E-14 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
0.128 1.16E-13 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.117 8.65E-12 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.116 1.35E-11 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.115 2.09E-11 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.114 3.12E-11 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
0.110 1.86E-10 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.108 4.04E-10 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.107 4.54E-10 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.107 5.82E-10 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.105 1.22E-9 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.104 1.28E-9 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.104 1.70E-9 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.103 2.01E-9 YOR137C SIA1 hom Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose