HIPHOP chemogenomics database

YLR191W / PEX13

Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR191W / PEX13

Click on Significant Values for Screen Details

Top fitness defect scores for YLR191W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2806	7952793	12.70	58.4 µM	1.04E-33		1	5.57E-37
2	SGTC_3303	9125618	6.82	40.6 µM	4.16E-11		8	4.52E-12
3	SGTC_3305	9127027	5.49	53.8 µM	8.77E-8		4	2.06E-8
4	SGTC_2992	9074591	5.24	71.4 µM	3.05E-7		6	8.10E-8
5	SGTC_690	glyoxal	5.08	20.3 µM	6.67E-7		59	1.92E-7
6	SGTC_769	0302-0231	4.98	76.0 µM	1.08E-6		17	3.26E-7
7	SGTC_1380	2291-0730	4.91	164.0 µM	1.49E-6		9	4.64E-7
8	SGTC_2614	arthonioic acid	4.90	13.4 µM	1.51E-6		9	4.70E-7
9	SGTC_939	1165-0479	4.66	45.3 µM	4.60E-6		13	1.60E-6
10	SGTC_271	rotenone	4.59	740.0 µM	6.30E-6		14	2.26E-6
11	SGTC_2481	5478948	4.37	45.2 µM	1.60E-5	PDR1	25	6.30E-6
12	SGTC_2607	solasodine	4.02	47.4 µM	6.40E-5		57	2.88E-5
13	SGTC_2512	diallyl trisulfide	4.00	49.2 µM	7.01E-5		7	3.19E-5
14	SGTC_706	4262-0057	3.98	46.9 µM	7.43E-5	fatty acid desaturase (OLE1)	33	3.40E-5
15	SGTC_653	0203-0016	3.96	55.2 µM	8.06E-5		13	3.71E-5
16	SGTC_2581	avocatin a	3.90	64.0 µM	1.03E-4	sphingolipid biosynthesis & PDR1	53	4.84E-5
17	SGTC_2762	leflunomide	3.90	42.1 µM	1.04E-4		30	4.90E-5
18	SGTC_2775	cyproheptadine	3.86	69.6 µM	1.17E-4		20	5.60E-5
19	SGTC_1545	lovastatin	3.86	49.4 µM	1.18E-4		26	5.65E-5
20	SGTC_598	3937-0236	3.86	20.2 µM	1.18E-4	ERG2	26	5.66E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.131	2.55E-14	YOR005C	DNL4	hom	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.117	1.01E-11	YDR333C	RQC1	hom	Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.115	2.29E-11	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.107	4.42E-10	YJL016W_p	YJL016W_p	hom	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
0.104	1.37E-9	YMR115W	MGR3	hom	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.103	1.93E-9	YMR135W-A_d	YMR135W-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100	5.89E-9	YER154W	OXA1	hom	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals
0.098	1.09E-8	YDR146C	SWI5	hom	Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.098	1.25E-8	YPL182C_d	YPL182C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.094	4.19E-8	YHL037C_d	YHL037C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093	5.87E-8	YGL164C	YRB30	hom	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.092	9.66E-8	YPL134C	ODC1	hom	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.091	1.27E-7	YOL052C	SPE2	hom	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.090	1.79E-7	YKL210W	UBA1	het	Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
0.089	2.20E-7	YOR173W	DCS2	hom	Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance