YLR192C / HCR1

Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR192C / HCR1

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.70|P-value:6.96E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.73|P-value:6.32E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.69|P-value:2.31E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-4.12|P-value:1.21E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.68|P-value:7.31E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.85|P-value:4.27E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.01|P-value:2.60E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.42|P-value:6.25E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:6.25|P-value:2.71E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.79|P-value:1.04E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.63|P-value:5.94E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:4.14|P-value:1.69E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.44|P-value:1.13E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:4.00|P-value:2.70E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:5.06|P-value:5.64E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:3.70|P-value:6.82E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.74|P-value:6.09E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.58|P-value:3.55E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.49|P-value:3.24E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.47|P-value:9.66E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.39|P-value:7.01E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.71|P-value:6.57E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.68|P-value:5.21E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.62|P-value:8.83E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.46|P-value:5.48E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.64|P-value:2.82E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.59|P-value:6.75E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.83|P-value:4.60E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.30|P-value:2.06E-8 ID:SGTC_1954|Compound:st077032|FD-Score:3.60|P-value:9.23E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.52|P-value:8.51E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.60|P-value:9.22E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.92|P-value:3.42E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.92|P-value:3.50E-4 ID:SGTC_2254|Compound:7938975|FD-Score:4.15|P-value:1.62E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.62|P-value:8.67E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.87|P-value:4.09E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.60|P-value:6.56E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-5.19|P-value:2.02E-6 ID:SGTC_2482|Compound:5981709|FD-Score:3.76|P-value:5.76E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.47|P-value:9.90E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.59|P-value:6.80E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-6.40|P-value:7.01E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.67|P-value:1.76E-9 ID:SGTC_2699|Compound:st077704|FD-Score:3.71|P-value:6.67E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.52|P-value:8.52E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.65|P-value:8.08E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-4.39|P-value:4.71E-5 ID:SGTC_3070|Compound:9117005|FD-Score:4.54|P-value:4.13E-5 ID:SGTC_3072|Compound:9116419|FD-Score:5.01|P-value:6.90E-6 ID:SGTC_3073|Compound:9114972|FD-Score:4.85|P-value:1.29E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.88|P-value:3.91E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.35|P-value:8.24E-5 ID:SGTC_3283|Compound:9109332|FD-Score:5.40|P-value:1.34E-6 ID:SGTC_3291|Compound:9121177|FD-Score:4.12|P-value:1.76E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.70|P-value:6.96E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.73|P-value:6.32E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.69|P-value:2.31E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-4.12|P-value:1.21E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.68|P-value:7.31E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.85|P-value:4.27E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.01|P-value:2.60E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.42|P-value:6.25E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:6.25|P-value:2.71E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.79|P-value:1.04E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.63|P-value:5.94E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:4.14|P-value:1.69E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.44|P-value:1.13E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:4.00|P-value:2.70E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:5.06|P-value:5.64E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:3.70|P-value:6.82E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.74|P-value:6.09E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.58|P-value:3.55E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.49|P-value:3.24E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.47|P-value:9.66E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.39|P-value:7.01E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.71|P-value:6.57E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.68|P-value:5.21E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.62|P-value:8.83E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.46|P-value:5.48E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.64|P-value:2.82E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.59|P-value:6.75E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.83|P-value:4.60E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.30|P-value:2.06E-8 ID:SGTC_1954|Compound:st077032|FD-Score:3.60|P-value:9.23E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.52|P-value:8.51E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.60|P-value:9.22E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.92|P-value:3.42E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.92|P-value:3.50E-4 ID:SGTC_2254|Compound:7938975|FD-Score:4.15|P-value:1.62E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.62|P-value:8.67E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.87|P-value:4.09E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.60|P-value:6.56E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-5.19|P-value:2.02E-6 ID:SGTC_2482|Compound:5981709|FD-Score:3.76|P-value:5.76E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.47|P-value:9.90E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.59|P-value:6.80E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-6.40|P-value:7.01E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.67|P-value:1.76E-9 ID:SGTC_2699|Compound:st077704|FD-Score:3.71|P-value:6.67E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.52|P-value:8.52E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.65|P-value:8.08E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-4.39|P-value:4.71E-5 ID:SGTC_3070|Compound:9117005|FD-Score:4.54|P-value:4.13E-5 ID:SGTC_3072|Compound:9116419|FD-Score:5.01|P-value:6.90E-6 ID:SGTC_3073|Compound:9114972|FD-Score:4.85|P-value:1.29E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.88|P-value:3.91E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.35|P-value:8.24E-5 ID:SGTC_3283|Compound:9109332|FD-Score:5.40|P-value:1.34E-6 ID:SGTC_3291|Compound:9121177|FD-Score:4.12|P-value:1.76E-4

Top fitness defect scores for YLR192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 6.30 66.3 µM 2.06E-8 NEO1 52 1.47E-10
2 SGTC_440 fluspirilene 6.25 35.1 µM 2.71E-8 1 2.11E-10
3 SGTC_576 1073-0113 5.44 22.7 µM 1.13E-6 redox potentiating 27 2.68E-8
4 SGTC_3283 9109332 5.40 35.8 µM 1.34E-6 DNA intercalators 3 3.32E-8
5 SGTC_724 3910-0327 5.06 137.0 µM 5.64E-6 ERG2 6 2.15E-7
6 SGTC_3072 9116419 5.01 49.5 µM 6.90E-6 ERG2 3 2.79E-7
7 SGTC_3073 9114972 4.85 49.5 µM 1.29E-5 60S ribosome export 2 6.26E-7
8 SGTC_56 0957-0365 4.69 83.2 µM 2.31E-5 Golgi 31 1.33E-6
9 SGTC_1466 k213-0079 4.64 57.5 µM 2.82E-5 6 1.74E-6
10 SGTC_1010 4112-3296 4.58 15.2 µM 3.55E-5 10 2.33E-6
11 SGTC_3070 9117005 4.54 49.5 µM 4.13E-5 2 2.84E-6
12 SGTC_1368 1852-0141 4.46 284.0 µM 5.48E-5 ERG2 29 4.10E-6
13 SGTC_364 0083-0097 4.42 67.7 µM 6.25E-5 17 4.86E-6
14 SGTC_1127 asiatic acid 4.39 681.4 nM 7.01E-5 15 5.63E-6
15 SGTC_3232 9132874 4.35 49.5 µM 8.24E-5 RPP1 & pyrimidine depletion 10 6.95E-6
16 SGTC_2254 7938975 4.15 95.2 µM 1.62E-4 45 1.67E-5
17 SGTC_526 4469-0568 4.14 170.0 µM 1.69E-4 azole & statin 31 1.77E-5
18 SGTC_3291 9121177 4.12 71.4 µM 1.76E-4 8 1.86E-5
19 SGTC_211 3455-0679 4.01 143.5 µM 2.60E-4 19 3.08E-5
20 SGTC_718 1130-0073 4.00 349.0 µM 2.70E-4 20 3.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.75E-13 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.117 1.10E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.105 9.89E-10 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.105 1.25E-9 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.102 3.05E-9 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.102 3.48E-9 YPL226W NEW1 hom ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction
0.102 3.56E-9 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.098 1.48E-8 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.094 4.95E-8 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.092 1.09E-7 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.089 2.22E-7 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.087 4.02E-7 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.087 5.16E-7 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.086 6.39E-7 YDR484W VPS52 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
0.083 1.41E-6 YPR139C LOA1 hom Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA