HIPHOP chemogenomics database

YLR195C / NMT1

N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction

Zygosity: Heterozygous strain

fixedexpanded
Profile for YLR195C / NMT1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR195C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2435	5706476	4.30	10.6 µM	1.01E-6		2	8.40E-6	0.78
2	SGTC_141	0443-0274	4.10	32.3 µM	2.96E-6	mitochondrial response to ROS	4	2.05E-5	0.23
3	SGTC_2439	5492030	3.93	7.2 µM	7.17E-6		6	4.25E-5	0.34
4	SGTC_968	1309-0633	3.88	340.0 µM	9.42E-6		5	5.33E-5	0.20
5	SGTC_2114	5491910	3.87	81.2 µM	9.82E-6		5	5.51E-5	0.01
6	SGTC_135	0933-0004	3.74	26.4 µM	1.80E-5	60S ribosome export	8	9.11E-5	0.23
7	SGTC_1278	0874-0585	3.67	172.0 µM	2.49E-5		9	1.19E-4	0.01
8	SGTC_864	0469-0573	3.67	172.0 µM	2.50E-5		6	1.19E-4	0.24
9	SGTC_134	0269-0018	3.65	6.9 µM	2.76E-5		21	1.30E-4	0.09
10	SGTC_2053	5265679	3.59	138.0 µM	3.75E-5		9	1.67E-4	0.15
11	SGTC_2506	ethyl hematommate	3.58	54.2 µM	3.91E-5	RPP1 & pyrimidine depletion	6	1.73E-4	0.04
12	SGTC_1366	1683-0113	3.50	21.9 µM	5.48E-5		6	2.29E-4	0.07
13	SGTC_1409	3909-8004	3.49	61.9 µM	5.91E-5		6	2.43E-4	0.23
14	SGTC_2136	5328288	3.47	199.3 µM	6.29E-5		13	2.56E-4	0.22
15	SGTC_2296	7971656	3.33	126.5 µM	1.17E-4		10	4.29E-4	0.16
16	SGTC_2261	9010538	3.28	184.7 µM	1.50E-4		9	5.28E-4	0.02
17	SGTC_3144	9087057	3.26	49.5 µM	1.62E-4		10	5.61E-4	0.01
18	SGTC_3300	9124615	3.25	50.5 µM	1.68E-4		6	5.78E-4	0.14
19	SGTC_1898	st060199	3.13	18.6 µM	2.78E-4		11	8.80E-4	0.02
20	SGTC_2752	diclazuril	3.10	33.1 µM	3.18E-4		20	9.82E-4	0.00

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.199	2.08E-31	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.175	2.32E-24	YDR235W	PRP42	het	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.171	1.92E-23	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.171	2.10E-23	YKL152C	GPM1	het	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.146	1.43E-17	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.142	1.56E-16	YHR019C	DED81	het	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.130	4.99E-14	YIR011C	STS1	het	Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.127	1.85E-13	YJL174W	KRE9	het	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.124	5.72E-13	YGR030C	POP6	het	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.121	2.17E-12	YGL111W	NSA1	het	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.120	3.74E-12	YPR160W	GPH1	hom	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.117	9.15E-12	YNL163C	RIA1	het	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.112	9.34E-11	YJL061W	NUP82	het	Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.111	1.26E-10	YBL084C	CDC27	het	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.111	1.32E-10	YDR021W	FAL1	het	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases