YLR195C / NMT1

N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR195C / NMT1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:-3.73|P-value:1.83E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-8.66|P-value:4.46E-22 ID:SGTC_134|Compound:0269-0018|FD-Score:3.65|P-value:2.76E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.74|P-value:1.80E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.90|P-value:6.42E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.10|P-value:2.96E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:2.90|P-value:6.87E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-2.84|P-value:8.19E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.08|P-value:3.34E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.67|P-value:2.50E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:2.81|P-value:9.73E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.35|P-value:1.04E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.88|P-value:9.42E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:2.97|P-value:5.29E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.12|P-value:2.77E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.05|P-value:3.77E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.09|P-value:3.10E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.67|P-value:2.49E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.23|P-value:1.69E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.00|P-value:4.44E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.50|P-value:5.48E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:5.91E-5 ID:SGTC_1603|Compound:st002045|FD-Score:2.95|P-value:5.60E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.13|P-value:2.78E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.59|P-value:3.75E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.87|P-value:9.82E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.95|P-value:5.58E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.34|P-value:1.05E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.47|P-value:6.29E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.28|P-value:1.50E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.30|P-value:1.01E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.93|P-value:7.17E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.58|P-value:3.91E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.84|P-value:8.70E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.23|P-value:1.69E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.10|P-value:3.18E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.92|P-value:6.28E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.25|P-value:1.68E-4 ID:SGTC_3344|Compound:9148862|FD-Score:2.87|P-value:7.67E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.73|P-value:1.83E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-8.66|P-value:4.46E-22 ID:SGTC_134|Compound:0269-0018|FD-Score:3.65|P-value:2.76E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.74|P-value:1.80E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.90|P-value:6.42E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.10|P-value:2.96E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:2.90|P-value:6.87E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-2.84|P-value:8.19E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.08|P-value:3.34E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.67|P-value:2.50E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:2.81|P-value:9.73E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.35|P-value:1.04E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.88|P-value:9.42E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:2.97|P-value:5.29E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.12|P-value:2.77E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.05|P-value:3.77E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.09|P-value:3.10E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.67|P-value:2.49E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.23|P-value:1.69E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.00|P-value:4.44E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.50|P-value:5.48E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:5.91E-5 ID:SGTC_1603|Compound:st002045|FD-Score:2.95|P-value:5.60E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.13|P-value:2.78E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.59|P-value:3.75E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.87|P-value:9.82E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.95|P-value:5.58E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.34|P-value:1.05E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.47|P-value:6.29E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.28|P-value:1.50E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.30|P-value:1.01E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.93|P-value:7.17E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.58|P-value:3.91E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.84|P-value:8.70E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.23|P-value:1.69E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.10|P-value:3.18E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.92|P-value:6.28E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.25|P-value:1.68E-4 ID:SGTC_3344|Compound:9148862|FD-Score:2.87|P-value:7.67E-4

Top fitness defect scores for YLR195C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2435 5706476 4.30 10.6 µM 1.01E-6 2 8.40E-6 0.78
2 SGTC_141 0443-0274 4.10 32.3 µM 2.96E-6 mitochondrial response to ROS 4 2.05E-5 0.23
3 SGTC_2439 5492030 3.93 7.2 µM 7.17E-6 6 4.25E-5 0.34
4 SGTC_968 1309-0633 3.88 340.0 µM 9.42E-6 5 5.33E-5 0.20
5 SGTC_2114 5491910 3.87 81.2 µM 9.82E-6 5 5.51E-5 0.01
6 SGTC_135 0933-0004 3.74 26.4 µM 1.80E-5 60S ribosome export 8 9.11E-5 0.23
7 SGTC_1278 0874-0585 3.67 172.0 µM 2.49E-5 9 1.19E-4 0.01
8 SGTC_864 0469-0573 3.67 172.0 µM 2.50E-5 6 1.19E-4 0.24
9 SGTC_134 0269-0018 3.65 6.9 µM 2.76E-5 21 1.30E-4 0.09
10 SGTC_2053 5265679 3.59 138.0 µM 3.75E-5 9 1.67E-4 0.15
11 SGTC_2506 ethyl hematommate 3.58 54.2 µM 3.91E-5 RPP1 & pyrimidine depletion 6 1.73E-4 0.04
12 SGTC_1366 1683-0113 3.50 21.9 µM 5.48E-5 6 2.29E-4 0.07
13 SGTC_1409 3909-8004 3.49 61.9 µM 5.91E-5 6 2.43E-4 0.23
14 SGTC_2136 5328288 3.47 199.3 µM 6.29E-5 13 2.56E-4 0.22
15 SGTC_2296 7971656 3.33 126.5 µM 1.17E-4 10 4.29E-4 0.16
16 SGTC_2261 9010538 3.28 184.7 µM 1.50E-4 9 5.28E-4 0.02
17 SGTC_3144 9087057 3.26 49.5 µM 1.62E-4 10 5.61E-4 0.01
18 SGTC_3300 9124615 3.25 50.5 µM 1.68E-4 6 5.78E-4 0.14
19 SGTC_1898 st060199 3.13 18.6 µM 2.78E-4 11 8.80E-4 0.02
20 SGTC_2752 diclazuril 3.10 33.1 µM 3.18E-4 20 9.82E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.08E-31 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.175 2.32E-24 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.171 1.92E-23 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.171 2.10E-23 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.146 1.43E-17 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.142 1.56E-16 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.130 4.99E-14 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.127 1.85E-13 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.124 5.72E-13 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.121 2.17E-12 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.120 3.74E-12 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.117 9.15E-12 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.112 9.34E-11 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.111 1.26E-10 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.111 1.32E-10 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases