YLR197W / NOP56

Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR197W / NOP56

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.64|P-value:8.32E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:5.30|P-value:1.64E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.83|P-value:5.33E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:5.07|P-value:2.98E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.53|P-value:8.80E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:5.09|P-value:2.80E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:8.72|P-value:1.60E-9 ID:SGTC_195|Compound:4234-0266|FD-Score:6.05|P-value:2.06E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:6.24|P-value:1.17E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:5.46|P-value:1.07E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-5.03|P-value:3.00E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-5.39|P-value:1.17E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.85|P-value:3.33E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:6.15|P-value:1.50E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.79|P-value:4.27E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.74|P-value:6.57E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.12|P-value:2.61E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.49|P-value:9.79E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.18|P-value:2.21E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.56|P-value:9.26E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.91|P-value:3.98E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:6.29|P-value:9.96E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.34|P-value:7.51E-9 ID:SGTC_1623|Compound:st003709|FD-Score:7.14|P-value:6.40E-7 ID:SGTC_1643|Compound:st009866|FD-Score:5.56|P-value:8.11E-5 ID:SGTC_1727|Compound:st034309|FD-Score:4.88|P-value:4.71E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:8.58|P-value:2.84E-9 ID:SGTC_1891|Compound:st059073|FD-Score:-4.78|P-value:5.46E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.64|P-value:8.44E-4 ID:SGTC_2021|Compound:4019055|FD-Score:6.71|P-value:2.64E-6 ID:SGTC_2024|Compound:5144227|FD-Score:-6.35|P-value:7.49E-6 ID:SGTC_2048|Compound:5246248|FD-Score:-4.82|P-value:4.99E-4 ID:SGTC_2067|Compound:5224629|FD-Score:5.94|P-value:2.86E-5 ID:SGTC_2134|Compound:5324836|FD-Score:5.36|P-value:1.42E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.87|P-value:4.83E-4 ID:SGTC_2214|Compound:7179297|FD-Score:4.92|P-value:4.23E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:10.60|P-value:3.09E-13 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.99|P-value:3.57E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.12|P-value:2.61E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.21|P-value:2.07E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.84|P-value:3.77E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.02|P-value:3.37E-4 ID:SGTC_2694|Compound:st077685|FD-Score:7.52|P-value:1.67E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.96|P-value:3.90E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.08|P-value:2.87E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-6.36|P-value:7.17E-6 ID:SGTC_3124|Compound:9127567|FD-Score:4.62|P-value:8.72E-4 ID:SGTC_3126|Compound:9127922|FD-Score:10.60|P-value:3.09E-13 ID:SGTC_3127|Compound:9126946|FD-Score:5.31|P-value:1.59E-4 ID:SGTC_3142|Compound:9086498|FD-Score:9.02|P-value:4.58E-10 ID:SGTC_3219|Compound:9131112|FD-Score:-6.66|P-value:2.80E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:4.64|P-value:8.32E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:5.30|P-value:1.64E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.83|P-value:5.33E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:5.07|P-value:2.98E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.53|P-value:8.80E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:5.09|P-value:2.80E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:8.72|P-value:1.60E-9 ID:SGTC_195|Compound:4234-0266|FD-Score:6.05|P-value:2.06E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:6.24|P-value:1.17E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:5.46|P-value:1.07E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-5.03|P-value:3.00E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-5.39|P-value:1.17E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.85|P-value:3.33E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:6.15|P-value:1.50E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.79|P-value:4.27E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.74|P-value:6.57E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.12|P-value:2.61E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.49|P-value:9.79E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.18|P-value:2.21E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.56|P-value:9.26E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.91|P-value:3.98E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:6.29|P-value:9.96E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.34|P-value:7.51E-9 ID:SGTC_1623|Compound:st003709|FD-Score:7.14|P-value:6.40E-7 ID:SGTC_1643|Compound:st009866|FD-Score:5.56|P-value:8.11E-5 ID:SGTC_1727|Compound:st034309|FD-Score:4.88|P-value:4.71E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:8.58|P-value:2.84E-9 ID:SGTC_1891|Compound:st059073|FD-Score:-4.78|P-value:5.46E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.64|P-value:8.44E-4 ID:SGTC_2021|Compound:4019055|FD-Score:6.71|P-value:2.64E-6 ID:SGTC_2024|Compound:5144227|FD-Score:-6.35|P-value:7.49E-6 ID:SGTC_2048|Compound:5246248|FD-Score:-4.82|P-value:4.99E-4 ID:SGTC_2067|Compound:5224629|FD-Score:5.94|P-value:2.86E-5 ID:SGTC_2134|Compound:5324836|FD-Score:5.36|P-value:1.42E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.87|P-value:4.83E-4 ID:SGTC_2214|Compound:7179297|FD-Score:4.92|P-value:4.23E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:10.60|P-value:3.09E-13 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.99|P-value:3.57E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.12|P-value:2.61E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.21|P-value:2.07E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.84|P-value:3.77E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.02|P-value:3.37E-4 ID:SGTC_2694|Compound:st077685|FD-Score:7.52|P-value:1.67E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.96|P-value:3.90E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.08|P-value:2.87E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-6.36|P-value:7.17E-6 ID:SGTC_3124|Compound:9127567|FD-Score:4.62|P-value:8.72E-4 ID:SGTC_3126|Compound:9127922|FD-Score:10.60|P-value:3.09E-13 ID:SGTC_3127|Compound:9126946|FD-Score:5.31|P-value:1.59E-4 ID:SGTC_3142|Compound:9086498|FD-Score:9.02|P-value:4.58E-10 ID:SGTC_3219|Compound:9131112|FD-Score:-6.66|P-value:2.80E-6

Top fitness defect scores for YLR197W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2405 ticlatone 10.60 3.5 µM 3.09E-13 2 1.50E-26 1.69
2 SGTC_3126 9127922 10.60 49.5 µM 3.09E-13 fatty acid desaturase (OLE1) 4 1.51E-26 0.46
3 SGTC_3142 9086498 9.02 49.5 µM 4.58E-10 iron homeostasis 10 9.29E-20 0.33
4 SGTC_171 k064-0041 8.72 9.7 µM 1.60E-9 heme requiring 3 1.34E-18 1.54
5 SGTC_1875 nocodazole 8.58 6.0 µM 2.84E-9 tubulin folding & SWR complex 11 4.60E-18 0.60
6 SGTC_1597 7-benzyloxygramine 8.34 47.5 µM 7.51E-9 calcium & mitochondrial duress 21 3.65E-17 0.31
7 SGTC_2694 st077685 7.52 81.9 µM 1.67E-7 endomembrane recycling 2 2.71E-14 1.99
8 SGTC_1623 st003709 7.14 20.3 µM 6.40E-7 calcium & mitochondrial duress 1 4.72E-13 1.03
9 SGTC_2021 4019055 6.71 173.0 µM 2.64E-6 endomembrane recycling 15 9.51E-12 0.07
10 SGTC_1480 1070-0044 6.29 41.2 µM 9.96E-6 2 1.58E-10 2.11
11 SGTC_212 3807-4682 6.24 38.8 µM 1.17E-5 tubulin folding & SWR complex 12 2.23E-10 0.10
12 SGTC_625 k213-0058 6.15 121.0 µM 1.50E-5 translation 3 3.78E-10 0.52
13 SGTC_195 4234-0266 6.05 16.6 µM 2.06E-5 5 7.39E-10 0.53
14 SGTC_2067 5224629 5.94 34.1 µM 2.86E-5 4 1.47E-9 0.03
15 SGTC_2604 4'-hydroxychalcone 5.84 11.3 µM 3.77E-5 3 2.63E-9 0.68
16 SGTC_800 3448-7362 5.79 155.0 µM 4.27E-5 translation 25 3.42E-9 0.14
17 SGTC_1643 st009866 5.56 20.2 µM 8.11E-5 11 1.32E-8 0.01
18 SGTC_168 3970-0862 5.53 530.5 µM 8.80E-5 20 1.57E-8 0.05
19 SGTC_1060 3448-7350 5.49 82.0 µM 9.79E-5 Golgi 9 1.96E-8 0.22
20 SGTC_432 NS 1619 5.46 61.3 µM 1.07E-4 1 2.39E-8 0.44

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.285 8.90E-64 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.191 9.60E-29 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.179 1.87E-25 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.155 1.62E-19 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.147 1.32E-17 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.135 5.45E-15 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.131 2.46E-14 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
0.130 3.65E-14 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.129 5.57E-14 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.126 2.35E-13 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.124 5.43E-13 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.120 2.80E-12 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.120 3.79E-12 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.119 4.22E-12 YML085C TUB1 het Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
0.119 5.78E-12 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER