YLR198C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR198C / YLR198C

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:5.88|P-value:4.59E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:3.56|P-value:2.35E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.70|P-value:1.41E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.26|P-value:9.76E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.55|P-value:2.47E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.17|P-value:8.90E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:6.84|P-value:1.26E-11 ID:SGTC_202|Compound:3594-0513|FD-Score:3.43|P-value:3.68E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.50|P-value:2.95E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.61|P-value:1.99E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.21|P-value:7.99E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:5.81|P-value:6.84E-9 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.28|P-value:9.00E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.45|P-value:3.44E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.43|P-value:5.53E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.83|P-value:6.39E-9 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.50|P-value:4.34E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.34|P-value:5.13E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.68|P-value:2.30E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-4.81|P-value:2.16E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.68|P-value:2.30E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.99|P-value:7.13E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.19|P-value:8.40E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.51|P-value:4.16E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.41|P-value:4.07E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.72|P-value:1.32E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.77|P-value:1.63E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.17|P-value:8.93E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.46|P-value:5.05E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.87|P-value:7.44E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.35|P-value:4.86E-4 ID:SGTC_2101|Compound:5377231|FD-Score:4.67|P-value:2.41E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.33|P-value:5.33E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.65|P-value:2.58E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.45|P-value:5.18E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.44|P-value:5.41E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.55|P-value:2.42E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.57|P-value:3.79E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.53|P-value:3.93E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.34|P-value:7.50E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.82|P-value:8.78E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.69|P-value:1.45E-4 ID:SGTC_2964|Compound:9083345|FD-Score:5.31|P-value:1.04E-7 ID:SGTC_3296|Compound:9122258|FD-Score:-3.52|P-value:4.12E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.83|P-value:1.14E-6 ID:SGTC_26|Compound:0302-0163|FD-Score:5.88|P-value:4.59E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:3.56|P-value:2.35E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.70|P-value:1.41E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.26|P-value:9.76E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.55|P-value:2.47E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.17|P-value:8.90E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:6.84|P-value:1.26E-11 ID:SGTC_202|Compound:3594-0513|FD-Score:3.43|P-value:3.68E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.50|P-value:2.95E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.61|P-value:1.99E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.21|P-value:7.99E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:5.81|P-value:6.84E-9 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.28|P-value:9.00E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.45|P-value:3.44E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.43|P-value:5.53E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.83|P-value:6.39E-9 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.50|P-value:4.34E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.34|P-value:5.13E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.68|P-value:2.30E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-4.81|P-value:2.16E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.68|P-value:2.30E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.99|P-value:7.13E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.19|P-value:8.40E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.51|P-value:4.16E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.41|P-value:4.07E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.72|P-value:1.32E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.77|P-value:1.63E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.17|P-value:8.93E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.46|P-value:5.05E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.87|P-value:7.44E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.35|P-value:4.86E-4 ID:SGTC_2101|Compound:5377231|FD-Score:4.67|P-value:2.41E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.33|P-value:5.33E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.65|P-value:2.58E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.45|P-value:5.18E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.44|P-value:5.41E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.55|P-value:2.42E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.57|P-value:3.79E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.53|P-value:3.93E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.34|P-value:7.50E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.82|P-value:8.78E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.69|P-value:1.45E-4 ID:SGTC_2964|Compound:9083345|FD-Score:5.31|P-value:1.04E-7 ID:SGTC_3296|Compound:9122258|FD-Score:-3.52|P-value:4.12E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.83|P-value:1.14E-6

Top fitness defect scores for YLR198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_195 4234-0266 6.84 16.6 µM 1.26E-11 3 3.88E-12 0.11
2 SGTC_26 0302-0163 5.88 425.2 µM 4.59E-9 heme biosynthesis & mitochondrial translocase 3 1.99E-9 0.44
3 SGTC_1099 5-nonyloxytryptamine 5.83 2.9 µM 6.39E-9 1 2.83E-9 1.30
4 SGTC_617 3770-0098 5.81 35.0 µM 6.84E-9 exosome 17 3.04E-9 0.69
5 SGTC_2964 9083345 5.31 53.4 µM 1.04E-7 6 5.38E-8 0.06
6 SGTC_3346 9158254 4.83 43.6 µM 1.14E-6 1 6.75E-7 0.20
7 SGTC_2101 5377231 4.67 179.2 µM 2.41E-6 2 1.49E-6 0.25
8 SGTC_2375 9072683 4.57 200.0 µM 3.79E-6 mitochondrial processes 3 2.41E-6 0.08
9 SGTC_1945 st075991 3.87 56.6 µM 7.44E-5 60S ribosome export 9 5.53E-5 0.03
10 SGTC_2692 st077426 3.82 47.7 µM 8.78E-5 7 6.59E-5 0.21
11 SGTC_282 k297-0036 3.76 65.7 µM 1.14E-4 2 8.63E-5 0.09
12 SGTC_1703 st026983 3.72 48.3 µM 1.32E-4 2 1.01E-4 0.14
13 SGTC_74 000s-0487 3.70 160.3 µM 1.41E-4 3 1.08E-4 0.13
14 SGTC_2693 st077581 3.69 40.7 µM 1.45E-4 7 1.11E-4 0.32
15 SGTC_518 1021-0119 3.61 62.6 µM 1.99E-4 ERG2 13 1.56E-4 0.12
16 SGTC_65 0798-0905 3.56 35.0 µM 2.35E-4 calcium & mitochondrial duress 12 1.86E-4 0.14
17 SGTC_2352 9027995 3.55 87.8 µM 2.42E-4 tubulin folding & SWR complex 6 1.91E-4 0.22
18 SGTC_114 0364-0001 3.55 490.3 µM 2.47E-4 7 1.95E-4 0.00
19 SGTC_445 e6 berbamine 3.50 66.0 µM 2.95E-4 NEO1-PIK1 36 2.36E-4 0.09
20 SGTC_800 3448-7362 3.45 155.0 µM 3.44E-4 translation 57 2.77E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.99E-19 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.146 1.75E-17 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.133 9.92E-15 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.113 6.05E-11 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.111 1.23E-10 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.104 1.30E-9 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.099 8.49E-9 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.097 1.84E-8 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.092 9.17E-8 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.092 1.11E-7 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.091 1.34E-7 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.090 1.73E-7 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.088 3.10E-7 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.088 3.55E-7 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.087 4.36E-7 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)