HIPHOP chemogenomics database

YLR198C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W

Zygosity: Heterozygous strain

fixedexpanded
Profile for YLR198C / YLR198C

Click on Significant Values for Screen Details

Top fitness defect scores for YLR198C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_195	4234-0266	6.84	16.6 µM	1.26E-11		3	3.88E-12	0.11
2	SGTC_26	0302-0163	5.88	425.2 µM	4.59E-9	heme biosynthesis & mitochondrial translocase	3	1.99E-9	0.44
3	SGTC_1099	5-nonyloxytryptamine	5.83	2.9 µM	6.39E-9		1	2.83E-9	1.30
4	SGTC_617	3770-0098	5.81	35.0 µM	6.84E-9	exosome	17	3.04E-9	0.69
5	SGTC_2964	9083345	5.31	53.4 µM	1.04E-7		6	5.38E-8	0.06
6	SGTC_3346	9158254	4.83	43.6 µM	1.14E-6		1	6.75E-7	0.20
7	SGTC_2101	5377231	4.67	179.2 µM	2.41E-6		2	1.49E-6	0.25
8	SGTC_2375	9072683	4.57	200.0 µM	3.79E-6	mitochondrial processes	3	2.41E-6	0.08
9	SGTC_1945	st075991	3.87	56.6 µM	7.44E-5	60S ribosome export	9	5.53E-5	0.03
10	SGTC_2692	st077426	3.82	47.7 µM	8.78E-5		7	6.59E-5	0.21
11	SGTC_282	k297-0036	3.76	65.7 µM	1.14E-4		2	8.63E-5	0.09
12	SGTC_1703	st026983	3.72	48.3 µM	1.32E-4		2	1.01E-4	0.14
13	SGTC_74	000s-0487	3.70	160.3 µM	1.41E-4		3	1.08E-4	0.13
14	SGTC_2693	st077581	3.69	40.7 µM	1.45E-4		7	1.11E-4	0.32
15	SGTC_518	1021-0119	3.61	62.6 µM	1.99E-4	ERG2	13	1.56E-4	0.12
16	SGTC_65	0798-0905	3.56	35.0 µM	2.35E-4	calcium & mitochondrial duress	12	1.86E-4	0.14
17	SGTC_2352	9027995	3.55	87.8 µM	2.42E-4	tubulin folding & SWR complex	6	1.91E-4	0.22
18	SGTC_114	0364-0001	3.55	490.3 µM	2.47E-4		7	1.95E-4	0.00
19	SGTC_445	e6 berbamine	3.50	66.0 µM	2.95E-4	NEO1-PIK1	36	2.36E-4	0.09
20	SGTC_800	3448-7362	3.45	155.0 µM	3.44E-4	translation	57	2.77E-4	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.155	1.99E-19	YLR129W	DIP2	het	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.146	1.75E-17	YPR137W	RRP9	het	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.133	9.92E-15	YML116W	ATR1	hom	Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.113	6.05E-11	YLR222C	UTP13	het	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.111	1.23E-10	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.104	1.30E-9	YHR069C	RRP4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.099	8.49E-9	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.097	1.84E-8	YOL077C	BRX1	het	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.092	9.17E-8	YML031W	NDC1	het	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.092	1.11E-7	YOL014W_p	YOL014W_p	hom	Putative protein of unknown function
0.091	1.34E-7	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.090	1.73E-7	YPL245W_p	YPL245W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.088	3.10E-7	YDR064W	RPS13	het	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.088	3.55E-7	YHL015W	RPS20	het	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.087	4.36E-7	YGR095C	RRP46	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)