Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YLR198C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.155 | 1.99E-19 | YLR129W | DIP2 | het | Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex |
0.146 | 1.75E-17 | YPR137W | RRP9 | het | Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein |
0.133 | 9.92E-15 | YML116W | ATR1 | hom | Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
0.113 | 6.05E-11 | YLR222C | UTP13 | het | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
0.111 | 1.23E-10 | YBL004W | UTP20 | het | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
0.104 | 1.30E-9 | YHR069C | RRP4 | het | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) |
0.099 | 8.49E-9 | YOL021C | DIS3 | het | Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress |
0.097 | 1.84E-8 | YOL077C | BRX1 | het | Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif |
0.092 | 9.17E-8 | YML031W | NDC1 | het | Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 |
0.092 | 1.11E-7 | YOL014W_p | YOL014W_p | hom | Putative protein of unknown function |
0.091 | 1.34E-7 | YGR158C | MTR3 | het | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) |
0.090 | 1.73E-7 | YPL245W_p | YPL245W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm |
0.088 | 3.10E-7 | YDR064W | RPS13 | het | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 |
0.088 | 3.55E-7 | YHL015W | RPS20 | het | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 |
0.087 | 4.36E-7 | YGR095C | RRP46 | het | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) |