YLR204W / QRI5

Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR204W / QRI5

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-5.57|P-value:3.12E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.74|P-value:6.61E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-5.93|P-value:7.51E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-5.97|P-value:6.48E-7 ID:SGTC_82|Compound:0054-0107|FD-Score:3.89|P-value:8.69E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.79|P-value:1.47E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:-5.09|P-value:1.83E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:17.80|P-value:2.63E-47 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.83|P-value:9.35E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.24|P-value:3.12E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.52|P-value:1.32E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.87|P-value:9.17E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.88|P-value:8.82E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:5.66|P-value:2.45E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.38|P-value:1.91E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.16|P-value:4.02E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.94|P-value:3.40E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.99|P-value:6.53E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:7.23|P-value:2.73E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.47|P-value:8.86E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:17.30|P-value:1.14E-44 ID:SGTC_543|Compound:3844-1095|FD-Score:8.40|P-value:5.78E-12 ID:SGTC_562|Compound:3772-2733|FD-Score:4.38|P-value:2.09E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.55|P-value:2.57E-12 ID:SGTC_690|Compound:glyoxal|FD-Score:6.31|P-value:1.79E-7 ID:SGTC_815|Compound:1582-0027|FD-Score:5.60|P-value:3.11E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:4.14|P-value:4.22E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:5.51|P-value:4.37E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.91|P-value:8.22E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.95|P-value:7.36E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.17|P-value:1.55E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.23|P-value:3.21E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.94|P-value:7.50E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.93|P-value:1.11E-8 ID:SGTC_1287|Compound:0971-0001|FD-Score:9.19|P-value:5.82E-14 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.14|P-value:4.24E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.00|P-value:2.77E-34 ID:SGTC_1712|Compound:st032288|FD-Score:6.60|P-value:5.08E-8 ID:SGTC_1724|Compound:st037281|FD-Score:4.04|P-value:5.67E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.10|P-value:4.80E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.52|P-value:4.24E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.25|P-value:1.13E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.51|P-value:7.57E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.45|P-value:9.82E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.55|P-value:5.55E-10 ID:SGTC_1934|Compound:st074720|FD-Score:5.01|P-value:2.70E-5 ID:SGTC_1941|Compound:st076221|FD-Score:9.07|P-value:1.23E-13 ID:SGTC_1960|Compound:st011366|FD-Score:5.07|P-value:2.16E-5 ID:SGTC_1990|Compound:st072050|FD-Score:4.46|P-value:1.63E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.96|P-value:3.19E-5 ID:SGTC_2343|Compound:7990716|FD-Score:4.33|P-value:2.39E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.87|P-value:9.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.98|P-value:6.14E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.95|P-value:3.24E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.65|P-value:8.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.33|P-value:2.42E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.80|P-value:6.51E-22 ID:SGTC_2788|Compound:5282734|FD-Score:3.94|P-value:7.48E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.25|P-value:3.11E-4 ID:SGTC_2875|Compound:9039966|FD-Score:5.16|P-value:1.59E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.79|P-value:5.60E-5 ID:SGTC_3025|Compound:9087895|FD-Score:6.14|P-value:3.62E-7 ID:SGTC_3233|Compound:9132340|FD-Score:4.73|P-value:6.83E-5 ID:SGTC_3250|Compound:9135583|FD-Score:5.45|P-value:5.47E-6 ID:SGTC_3285|Compound:9112818|FD-Score:5.28|P-value:1.02E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-5.57|P-value:3.12E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.74|P-value:6.61E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-5.93|P-value:7.51E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-5.97|P-value:6.48E-7 ID:SGTC_82|Compound:0054-0107|FD-Score:3.89|P-value:8.69E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.79|P-value:1.47E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:-5.09|P-value:1.83E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:17.80|P-value:2.63E-47 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.83|P-value:9.35E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.24|P-value:3.12E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.52|P-value:1.32E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.87|P-value:9.17E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.88|P-value:8.82E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:5.66|P-value:2.45E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.38|P-value:1.91E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.16|P-value:4.02E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.94|P-value:3.40E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.99|P-value:6.53E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:7.23|P-value:2.73E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.47|P-value:8.86E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:17.30|P-value:1.14E-44 ID:SGTC_543|Compound:3844-1095|FD-Score:8.40|P-value:5.78E-12 ID:SGTC_562|Compound:3772-2733|FD-Score:4.38|P-value:2.09E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.55|P-value:2.57E-12 ID:SGTC_690|Compound:glyoxal|FD-Score:6.31|P-value:1.79E-7 ID:SGTC_815|Compound:1582-0027|FD-Score:5.60|P-value:3.11E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:4.14|P-value:4.22E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:5.51|P-value:4.37E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.91|P-value:8.22E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.95|P-value:7.36E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.17|P-value:1.55E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.23|P-value:3.21E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.94|P-value:7.50E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.93|P-value:1.11E-8 ID:SGTC_1287|Compound:0971-0001|FD-Score:9.19|P-value:5.82E-14 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.14|P-value:4.24E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.00|P-value:2.77E-34 ID:SGTC_1712|Compound:st032288|FD-Score:6.60|P-value:5.08E-8 ID:SGTC_1724|Compound:st037281|FD-Score:4.04|P-value:5.67E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.10|P-value:4.80E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.52|P-value:4.24E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.25|P-value:1.13E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.51|P-value:7.57E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.45|P-value:9.82E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.55|P-value:5.55E-10 ID:SGTC_1934|Compound:st074720|FD-Score:5.01|P-value:2.70E-5 ID:SGTC_1941|Compound:st076221|FD-Score:9.07|P-value:1.23E-13 ID:SGTC_1960|Compound:st011366|FD-Score:5.07|P-value:2.16E-5 ID:SGTC_1990|Compound:st072050|FD-Score:4.46|P-value:1.63E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.96|P-value:3.19E-5 ID:SGTC_2343|Compound:7990716|FD-Score:4.33|P-value:2.39E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.87|P-value:9.15E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.98|P-value:6.14E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.95|P-value:3.24E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.65|P-value:8.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.33|P-value:2.42E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.80|P-value:6.51E-22 ID:SGTC_2788|Compound:5282734|FD-Score:3.94|P-value:7.48E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.25|P-value:3.11E-4 ID:SGTC_2875|Compound:9039966|FD-Score:5.16|P-value:1.59E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.79|P-value:5.60E-5 ID:SGTC_3025|Compound:9087895|FD-Score:6.14|P-value:3.62E-7 ID:SGTC_3233|Compound:9132340|FD-Score:4.73|P-value:6.83E-5 ID:SGTC_3250|Compound:9135583|FD-Score:5.45|P-value:5.47E-6 ID:SGTC_3285|Compound:9112818|FD-Score:5.28|P-value:1.02E-5

Top fitness defect scores for YLR204W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 17.80 51.8 µM 2.63E-47 ERAD & cell cycle 6 2.75E-71
2 SGTC_528 3492-0019 17.30 172.0 µM 1.14E-44 calcium & mitochondrial duress 4 2.91E-67
3 SGTC_1687 st020778 15.00 55.4 µM 2.77E-34 21 2.07E-51
4 SGTC_2752 diclazuril 11.80 33.1 µM 6.51E-22 14 1.54E-32
5 SGTC_1287 0971-0001 9.19 34.6 µM 5.82E-14 sphingolipid biosynthesis & PDR1 12 1.99E-20
6 SGTC_1941 st076221 9.07 61.8 µM 1.23E-13 sphingolipid biosynthesis & PDR1 17 6.23E-20
7 SGTC_682 0kpi-0099 8.55 17.0 µM 2.57E-12 12 6.33E-18
8 SGTC_543 3844-1095 8.40 191.0 µM 5.78E-12 ERG2 7 2.17E-17
9 SGTC_1877 wortmannin 7.55 25.0 µM 5.55E-10 25 2.23E-14
10 SGTC_377 3970-0964 7.23 33.1 µM 2.73E-9 8 2.50E-13
11 SGTC_1277 0873-0036 6.93 22.0 µM 1.11E-8 PDR1 2 2.10E-12
12 SGTC_1712 st032288 6.60 53.4 µM 5.08E-8 calcium & mitochondrial duress 64 2.10E-11
13 SGTC_1803 st050068 6.51 52.4 µM 7.57E-8 NEO1-PIK1 66 3.85E-11
14 SGTC_488 nitrendipine 6.47 139.0 µM 8.86E-8 12 4.89E-11
15 SGTC_1875 nocodazole 6.45 6.0 µM 9.82E-8 tubulin folding & SWR complex 26 5.72E-11
16 SGTC_690 glyoxal 6.31 20.3 µM 1.79E-7 39 1.42E-10
17 SGTC_3025 9087895 6.14 49.5 µM 3.62E-7 PDR1 12 4.13E-10
18 SGTC_87 0100-0052 5.79 35.5 µM 1.47E-6 37 3.43E-9
19 SGTC_293 4049-0273 5.66 38.5 µM 2.45E-6 4 7.44E-9
20 SGTC_815 1582-0027 5.60 36.9 µM 3.11E-6 3 1.06E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.446 5.66E-164 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.428 3.68E-149 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.360 3.54E-103 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.343 1.65E-93 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.334 2.40E-88 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.329 3.19E-85 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.328 4.30E-85 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.296 5.09E-69 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.273 1.65E-58 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.255 4.51E-51 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.255 5.24E-51 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.253 3.00E-50 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.253 4.00E-50 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.240 2.98E-45 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.240 3.48E-45 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p