YLR211C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR211C / YLR211C

Click on Significant Values for Screen Details ID:SGTC_263|Compound:alizarin|FD-Score:4.26|P-value:2.47E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:2.95|P-value:7.67E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.11|P-value:4.22E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.25|P-value:2.37E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.62|P-value:5.24E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.65|P-value:4.44E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.72|P-value:3.23E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-2.91|P-value:8.86E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.17|P-value:3.28E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.85|P-value:1.75E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.00|P-value:6.34E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.06|P-value:5.11E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.30|P-value:2.03E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.22|P-value:2.69E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.31|P-value:1.90E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.12|P-value:4.05E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.15|P-value:3.64E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.32|P-value:1.85E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.03|P-value:5.75E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.88|P-value:9.97E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.30|P-value:1.97E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-2.89|P-value:9.56E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-5.16|P-value:1.45E-8 ID:SGTC_2342|Compound:7990637|FD-Score:3.50|P-value:8.53E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-3.30|P-value:1.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.17|P-value:3.81E-6 ID:SGTC_2701|Compound:st077767|FD-Score:-3.02|P-value:5.87E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-6.73|P-value:2.45E-13 ID:SGTC_2757|Compound:clomiphene|FD-Score:9.67|P-value:1.52E-25 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.03|P-value:5.74E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.65|P-value:4.44E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.09|P-value:4.45E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.92|P-value:1.28E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.47|P-value:9.60E-5 ID:SGTC_3004|Compound:9076122|FD-Score:4.12|P-value:4.82E-6 ID:SGTC_3129|Compound:9127257|FD-Score:-3.39|P-value:1.37E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.83|P-value:1.12E-7 ID:SGTC_3198|Compound:9112019|FD-Score:3.51|P-value:8.47E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.61|P-value:5.24E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-5.07|P-value:2.55E-8 ID:SGTC_3213|Compound:9129884|FD-Score:-3.35|P-value:1.60E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.05|P-value:6.85E-6 ID:SGTC_3218|Compound:9131285|FD-Score:-3.11|P-value:4.20E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-2.99|P-value:6.56E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.14|P-value:3.68E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.95|P-value:7.47E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.18|P-value:3.11E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.76|P-value:1.59E-7 ID:SGTC_263|Compound:alizarin|FD-Score:4.26|P-value:2.47E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:2.95|P-value:7.67E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.11|P-value:4.22E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.25|P-value:2.37E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.62|P-value:5.24E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.65|P-value:4.44E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.72|P-value:3.23E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-2.91|P-value:8.86E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.17|P-value:3.28E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.85|P-value:1.75E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.00|P-value:6.34E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.06|P-value:5.11E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.30|P-value:2.03E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.22|P-value:2.69E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.31|P-value:1.90E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.12|P-value:4.05E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.15|P-value:3.64E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.32|P-value:1.85E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.03|P-value:5.75E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.88|P-value:9.97E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.30|P-value:1.97E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-2.89|P-value:9.56E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-5.16|P-value:1.45E-8 ID:SGTC_2342|Compound:7990637|FD-Score:3.50|P-value:8.53E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-3.30|P-value:1.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.17|P-value:3.81E-6 ID:SGTC_2701|Compound:st077767|FD-Score:-3.02|P-value:5.87E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-6.73|P-value:2.45E-13 ID:SGTC_2757|Compound:clomiphene|FD-Score:9.67|P-value:1.52E-25 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.03|P-value:5.74E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.65|P-value:4.44E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.09|P-value:4.45E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.92|P-value:1.28E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.47|P-value:9.60E-5 ID:SGTC_3004|Compound:9076122|FD-Score:4.12|P-value:4.82E-6 ID:SGTC_3129|Compound:9127257|FD-Score:-3.39|P-value:1.37E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.83|P-value:1.12E-7 ID:SGTC_3198|Compound:9112019|FD-Score:3.51|P-value:8.47E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.61|P-value:5.24E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-5.07|P-value:2.55E-8 ID:SGTC_3213|Compound:9129884|FD-Score:-3.35|P-value:1.60E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.05|P-value:6.85E-6 ID:SGTC_3218|Compound:9131285|FD-Score:-3.11|P-value:4.20E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-2.99|P-value:6.56E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.14|P-value:3.68E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.95|P-value:7.47E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.18|P-value:3.11E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.76|P-value:1.59E-7

Top fitness defect scores for YLR211C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2757 clomiphene 9.67 4.2 µM 1.52E-25 fatty acid desaturase (OLE1) 2 2.01E-22
2 SGTC_3146 9095609 4.83 49.5 µM 1.12E-7 8 6.99E-7
3 SGTC_263 alizarin 4.26 107.9 µM 2.47E-6 iron homeostasis 49 1.04E-5
4 SGTC_2690 usnic acid 4.17 100.0 µM 3.81E-6 24 1.52E-5
5 SGTC_3004 9076122 4.12 71.4 µM 4.82E-6 14 1.86E-5
6 SGTC_944 3370-0224 3.72 231.0 µM 3.23E-5 30 9.82E-5
7 SGTC_729 4092-0585 3.65 94.1 µM 4.44E-5 33 1.29E-4
8 SGTC_561 1550-0330 3.62 72.9 µM 5.24E-5 14 1.50E-4
9 SGTC_3198 9112019 3.51 49.5 µM 8.47E-5 mitochondrial processes 27 2.28E-4
10 SGTC_2342 7990637 3.50 118.9 µM 8.53E-5 RNA processing & uracil transport 54 2.29E-4
11 SGTC_1744 st037937 3.32 38.9 µM 1.85E-4 49 4.52E-4
12 SGTC_1393 3470-5649 3.30 58.2 µM 2.03E-4 60S ribosome export 29 4.89E-4
13 SGTC_2714 st079313 3.17 56.9 µM 3.32E-4 27 7.54E-4
14 SGTC_1700 st030840 3.15 7.9 µM 3.64E-4 PDR1 43 8.17E-4
15 SGTC_291 4130-1278 3.11 35.5 µM 4.22E-4 Golgi 39 9.31E-4
16 SGTC_1310 1188-0297 3.06 994.0 nM 5.11E-4 azole & statin 72 0.00110
17 SGTC_2759 disulfiram 3.03 3.4 µM 5.74E-4 80 0.00122
18 SGTC_1748 st037455 3.03 53.6 µM 5.75E-4 79 0.00122
19 SGTC_278 4092-0821 2.95 23.9 µM 7.67E-4 plasma membrane duress 91 0.00157
20 SGTC_1751 st044839 2.88 27.2 µM 9.97E-4 Golgi 36 0.00198

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 7.08E-31 YNL076W MKS1 hom Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
0.169 8.41E-23 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.167 2.68E-22 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.153 5.25E-19 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.122 1.29E-12 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.109 2.47E-10 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.102 2.78E-9 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.101 5.35E-9 YER105C NUP157 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
0.099 8.86E-9 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.099 9.06E-9 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.097 2.01E-8 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.095 4.02E-8 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.093 6.76E-8 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.093 8.02E-8 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.092 9.69E-8 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants