YLR213C / CRR1

Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR213C / CRR1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-2.81|P-value:7.35E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.79|P-value:7.86E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.32|P-value:1.24E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.72|P-value:1.89E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.03|P-value:4.11E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.79|P-value:7.87E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.01|P-value:4.53E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.88|P-value:5.56E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.81|P-value:9.78E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.57|P-value:2.08E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.05|P-value:2.80E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.83|P-value:1.13E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.10|P-value:2.27E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.02|P-value:4.34E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:4.18|P-value:1.82E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.12|P-value:2.87E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.82|P-value:1.19E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.51|P-value:5.16E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.91|P-value:5.20E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.74|P-value:1.77E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.40|P-value:5.53E-7 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.66|P-value:2.54E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.37|P-value:4.02E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-8.36|P-value:3.13E-21 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.81|P-value:9.89E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.97|P-value:5.23E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.68|P-value:1.66E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.30|P-value:9.72E-7 ID:SGTC_2485|Compound:5633444|FD-Score:2.83|P-value:8.90E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.82|P-value:1.16E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.82|P-value:7.13E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.11|P-value:3.01E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.90|P-value:5.03E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.03|P-value:2.99E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.80|P-value:9.96E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.51|P-value:3.69E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.14|P-value:1.93E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.83|P-value:7.78E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.26|P-value:1.15E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-2.82|P-value:7.02E-4 ID:SGTC_3108|Compound:9121785|FD-Score:2.97|P-value:5.29E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.00|P-value:4.63E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.88|P-value:1.97E-8 ID:SGTC_3317|Compound:9138495|FD-Score:-3.25|P-value:1.18E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.81|P-value:7.35E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.79|P-value:7.86E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.32|P-value:1.24E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.72|P-value:1.89E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.03|P-value:4.11E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.79|P-value:7.87E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.01|P-value:4.53E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.88|P-value:5.56E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.81|P-value:9.78E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.57|P-value:2.08E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.05|P-value:2.80E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.83|P-value:1.13E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.10|P-value:2.27E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.02|P-value:4.34E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:4.18|P-value:1.82E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.12|P-value:2.87E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.82|P-value:1.19E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.51|P-value:5.16E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.91|P-value:5.20E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.74|P-value:1.77E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.40|P-value:5.53E-7 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.66|P-value:2.54E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.37|P-value:4.02E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-8.36|P-value:3.13E-21 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.81|P-value:9.89E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.97|P-value:5.23E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.68|P-value:1.66E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.30|P-value:9.72E-7 ID:SGTC_2485|Compound:5633444|FD-Score:2.83|P-value:8.90E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.82|P-value:1.16E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.82|P-value:7.13E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.11|P-value:3.01E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.90|P-value:5.03E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.03|P-value:2.99E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.80|P-value:9.96E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.51|P-value:3.69E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.14|P-value:1.93E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.83|P-value:7.78E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.26|P-value:1.15E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-2.82|P-value:7.02E-4 ID:SGTC_3108|Compound:9121785|FD-Score:2.97|P-value:5.29E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.00|P-value:4.63E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.88|P-value:1.97E-8 ID:SGTC_3317|Compound:9138495|FD-Score:-3.25|P-value:1.18E-4

Top fitness defect scores for YLR213C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_925 2064-1272 4.57 59.6 µM 2.08E-7 14 2.48E-6
2 SGTC_1451 4152-0210 4.40 104.0 µM 5.53E-7 14 5.49E-6
3 SGTC_2318 6029776 4.30 164.0 µM 9.72E-7 15 8.69E-6
4 SGTC_986 1493-0483 4.18 84.0 µM 1.82E-6 10 1.45E-5
5 SGTC_964 1287-0107 4.02 19.4 µM 4.34E-6 cell wall 38 2.94E-5
6 SGTC_940 3232-1287 3.83 54.8 µM 1.13E-5 NEO1 45 6.41E-5
7 SGTC_2539 epi(13)torulosol 3.82 80.0 µM 1.16E-5 30 6.58E-5
8 SGTC_1241 0364-0022 3.82 50.8 µM 1.19E-5 ERG2 36 6.71E-5
9 SGTC_1448 4255-0083 3.74 152.0 µM 1.77E-5 ERG2 23 9.27E-5
10 SGTC_67 0335-0847 3.72 266.0 µM 1.89E-5 ubiquinone biosynthesis & proteasome 132 9.78E-5
11 SGTC_1461 k072-0203 3.66 53.8 µM 2.54E-5 22 1.25E-4
12 SGTC_1260 0700-1617 3.51 7.8 µM 5.16E-5 calcium & mitochondrial duress 46 2.22E-4
13 SGTC_65 0798-0905 3.32 35.0 µM 1.24E-4 calcium & mitochondrial duress 130 4.56E-4
14 SGTC_1212 0520-0165 3.12 585.0 µM 2.87E-4 73 9.08E-4
15 SGTC_2806 7952793 3.11 58.4 µM 3.01E-4 58 9.43E-4
16 SGTC_183 3914-0051 3.03 30.6 µM 4.11E-4 60S ribosome export 67 0.00122
17 SGTC_715 0868-0130 3.01 184.0 µM 4.53E-4 31 0.00132
18 SGTC_3150 9097574 3.00 49.5 µM 4.63E-4 33 0.00134
19 SGTC_2014 4013930 2.97 200.0 µM 5.23E-4 90 0.00148
20 SGTC_3108 9121785 2.97 49.5 µM 5.29E-4 54 0.00150

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 3.14E-71 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.295 2.10E-68 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.286 7.66E-64 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.282 2.36E-62 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.282 2.81E-62 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.280 2.90E-61 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.280 2.20E-61 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.277 4.51E-60 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.275 4.28E-59 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.269 3.36E-56 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.257 1.51E-51 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.255 4.75E-51 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.252 7.40E-50 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.252 2.07E-49 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.251 1.90E-49 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation