YLR215C / CDC123

Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR215C / CDC123

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:3.05|P-value:4.12E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.26|P-value:1.97E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.19|P-value:2.36E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.32|P-value:1.53E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.36|P-value:1.29E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.17|P-value:2.57E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.30|P-value:1.50E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.21|P-value:2.14E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:2.85|P-value:8.87E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.65|P-value:3.24E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:5.38|P-value:2.03E-9 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.28|P-value:1.85E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.89|P-value:4.46E-8 ID:SGTC_725|Compound:1497-0963|FD-Score:3.31|P-value:1.43E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.88|P-value:1.08E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.71|P-value:1.25E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.00|P-value:4.97E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.84|P-value:9.38E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.24|P-value:2.18E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.91|P-value:7.24E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:2.87|P-value:8.40E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.43|P-value:9.91E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.68|P-value:2.77E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.17|P-value:2.58E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.93|P-value:8.28E-6 ID:SGTC_1991|Compound:st073000|FD-Score:4.43|P-value:6.35E-7 ID:SGTC_2126|Compound:5251174|FD-Score:-4.37|P-value:9.89E-7 ID:SGTC_2128|Compound:5255449|FD-Score:-4.83|P-value:7.38E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.41|P-value:1.06E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.05|P-value:4.17E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-4.65|P-value:2.15E-7 ID:SGTC_2185|Compound:6113692|FD-Score:5.49|P-value:9.51E-10 ID:SGTC_2238|Compound:6671620|FD-Score:-3.34|P-value:1.40E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.99|P-value:7.28E-6 ID:SGTC_2434|Compound:5670830|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.42|P-value:8.94E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.91|P-value:8.02E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.12|P-value:3.17E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.06|P-value:4.35E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-2.90|P-value:8.37E-4 ID:SGTC_2832|Compound:7992762|FD-Score:2.82|P-value:9.90E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.18|P-value:2.43E-4 ID:SGTC_2845|Compound:9003024|FD-Score:2.85|P-value:8.88E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.60|P-value:2.36E-7 ID:SGTC_2990|Compound:9074105|FD-Score:3.28|P-value:1.63E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.77|P-value:2.05E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.12|P-value:3.19E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.35|P-value:1.39E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.06|P-value:4.37E-6 ID:SGTC_3218|Compound:9131285|FD-Score:-3.12|P-value:3.46E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-2.99|P-value:5.85E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-2.93|P-value:7.46E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.26|P-value:1.95E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.05|P-value:4.12E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.26|P-value:1.97E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.19|P-value:2.36E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.32|P-value:1.53E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.36|P-value:1.29E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.17|P-value:2.57E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.30|P-value:1.50E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.21|P-value:2.14E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:2.85|P-value:8.87E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.65|P-value:3.24E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:5.38|P-value:2.03E-9 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.28|P-value:1.85E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.89|P-value:4.46E-8 ID:SGTC_725|Compound:1497-0963|FD-Score:3.31|P-value:1.43E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.88|P-value:1.08E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.71|P-value:1.25E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.00|P-value:4.97E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.84|P-value:9.38E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.24|P-value:2.18E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.91|P-value:7.24E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:2.87|P-value:8.40E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.43|P-value:9.91E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.68|P-value:2.77E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.17|P-value:2.58E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.93|P-value:8.28E-6 ID:SGTC_1991|Compound:st073000|FD-Score:4.43|P-value:6.35E-7 ID:SGTC_2126|Compound:5251174|FD-Score:-4.37|P-value:9.89E-7 ID:SGTC_2128|Compound:5255449|FD-Score:-4.83|P-value:7.38E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.41|P-value:1.06E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.05|P-value:4.17E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-4.65|P-value:2.15E-7 ID:SGTC_2185|Compound:6113692|FD-Score:5.49|P-value:9.51E-10 ID:SGTC_2238|Compound:6671620|FD-Score:-3.34|P-value:1.40E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.99|P-value:7.28E-6 ID:SGTC_2434|Compound:5670830|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.42|P-value:8.94E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.91|P-value:8.02E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.12|P-value:3.17E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.06|P-value:4.35E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-2.90|P-value:8.37E-4 ID:SGTC_2832|Compound:7992762|FD-Score:2.82|P-value:9.90E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.18|P-value:2.43E-4 ID:SGTC_2845|Compound:9003024|FD-Score:2.85|P-value:8.88E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.60|P-value:2.36E-7 ID:SGTC_2990|Compound:9074105|FD-Score:3.28|P-value:1.63E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.77|P-value:2.05E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.12|P-value:3.19E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.35|P-value:1.39E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.06|P-value:4.37E-6 ID:SGTC_3218|Compound:9131285|FD-Score:-3.12|P-value:3.46E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-2.99|P-value:5.85E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-2.93|P-value:7.46E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.26|P-value:1.95E-4

Top fitness defect scores for YLR215C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2185 6113692 5.49 200.0 µM 9.51E-10 ergosterol biosynthesis 2 1.98E-8 0.34
2 SGTC_696 1560-0013 5.38 611.0 µM 2.03E-9 4 3.77E-8 1.06
3 SGTC_705 1124-0212 4.89 310.0 µM 4.46E-8 2 5.08E-7 0.37
4 SGTC_1212 0520-0165 4.71 585.0 µM 1.25E-7 3 1.21E-6 0.03
5 SGTC_2988 9073640 4.60 71.4 µM 2.36E-7 8 2.07E-6 0.28
6 SGTC_1991 st073000 4.43 8.9 µM 6.35E-7 NEO1 14 4.77E-6 0.20
7 SGTC_2592 piperlongumine 4.06 83.3 µM 4.35E-6 TSC3-RPN4 5 2.42E-5 0.01
8 SGTC_3187 9109394 4.06 49.5 µM 4.37E-6 Golgi 6 2.43E-5 0.06
9 SGTC_1897 st060201 3.93 15.0 µM 8.28E-6 mitochondrial processes 8 4.17E-5 0.49
10 SGTC_771 0250-0039 3.88 27.3 µM 1.08E-5 1 5.21E-5 0.17
11 SGTC_1731 st035964 3.68 63.0 µM 2.77E-5 17 1.16E-4 0.08
12 SGTC_609 0986-0026 3.65 86.3 µM 3.24E-5 calcium & mitochondrial duress 15 1.32E-4 0.03
13 SGTC_2457 5731572 3.42 11.7 µM 8.94E-5 3 3.12E-4 0.03
14 SGTC_725 1497-0963 3.31 19.0 µM 1.43E-4 copper-dependent oxidative stress 5 4.63E-4 0.09
15 SGTC_513 4245-1575 3.30 41.7 µM 1.50E-4 unfolded protein response 47 4.82E-4 0.04
16 SGTC_2990 9074105 3.28 71.4 µM 1.63E-4 8 5.18E-4 0.19
17 SGTC_603 3794-0023 3.21 45.9 µM 2.14E-4 3 6.53E-4 0.02
18 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.19 44.4 nM 2.36E-4 DNA damage response 15 7.08E-4 0.02
19 SGTC_2844 9010103 3.18 26.0 µM 2.43E-4 14 7.25E-4 0.04
20 SGTC_507 nimesulide 3.17 162.0 µM 2.57E-4 10 7.60E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.60E-16 YER166W DNF1 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.119 4.42E-12 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.114 3.79E-11 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.108 3.73E-10 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.103 2.06E-9 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.090 1.74E-7 YDR092W UBC13 hom Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
0.089 2.49E-7 YDL093W PMT5 hom Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
0.085 9.33E-7 YOR067C ALG8 hom Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
0.085 9.41E-7 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.084 1.05E-6 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.084 1.27E-6 YGR248W SOL4 hom 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
0.083 1.49E-6 YNL050C_p YNL050C_p hom Putative protein of unknown function; YNL050c is not an essential gene
0.081 2.62E-6 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.081 2.77E-6 YOL159C YOL159C hom Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
0.078 6.23E-6 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins