YLR218C / COA4

Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR218C / COA4

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:12.60|P-value:5.81E-37 ID:SGTC_310|Compound:1273-0058|FD-Score:3.64|P-value:1.14E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.91|P-value:1.79E-12 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.80|P-value:6.03E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.38|P-value:4.88E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.36|P-value:4.85E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.04|P-value:2.17E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:3.36|P-value:3.28E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.27|P-value:4.57E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.20|P-value:5.74E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.85|P-value:4.86E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.55|P-value:2.41E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.31|P-value:6.53E-6 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.19|P-value:1.15E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.80|P-value:5.94E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.18|P-value:6.20E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.36|P-value:4.99E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.77|P-value:1.04E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.80|P-value:9.36E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.49|P-value:2.05E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.23|P-value:1.01E-20 ID:SGTC_1713|Compound:st033146|FD-Score:-3.64|P-value:1.78E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.16|P-value:6.61E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.66|P-value:1.06E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.43|P-value:2.56E-4 ID:SGTC_2035|Compound:5154463|FD-Score:5.06|P-value:1.69E-7 ID:SGTC_2052|Compound:5265182|FD-Score:3.30|P-value:4.10E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.22|P-value:1.65E-5 ID:SGTC_2329|Compound:6138490|FD-Score:4.46|P-value:3.35E-6 ID:SGTC_2525|Compound:harmine|FD-Score:3.88|P-value:4.28E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.42|P-value:3.97E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.52|P-value:1.79E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.79|P-value:6.18E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-4.62|P-value:2.63E-6 ID:SGTC_2963|Compound:9082507|FD-Score:-5.27|P-value:9.74E-8 ID:SGTC_3052|Compound:9092717|FD-Score:3.24|P-value:5.03E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.07|P-value:9.05E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-4.59|P-value:3.11E-6 ID:SGTC_3091|Compound:9116372|FD-Score:3.12|P-value:7.70E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-4.76|P-value:1.36E-6 ID:SGTC_3214|Compound:9129694|FD-Score:4.43|P-value:3.87E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.25|P-value:4.80E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.60|P-value:5.81E-37 ID:SGTC_310|Compound:1273-0058|FD-Score:3.64|P-value:1.14E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.91|P-value:1.79E-12 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.80|P-value:6.03E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.38|P-value:4.88E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.36|P-value:4.85E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.04|P-value:2.17E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:3.36|P-value:3.28E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.27|P-value:4.57E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.20|P-value:5.74E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.85|P-value:4.86E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.55|P-value:2.41E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.31|P-value:6.53E-6 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.19|P-value:1.15E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.80|P-value:5.94E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.18|P-value:6.20E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.36|P-value:4.99E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.77|P-value:1.04E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.80|P-value:9.36E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.49|P-value:2.05E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.23|P-value:1.01E-20 ID:SGTC_1713|Compound:st033146|FD-Score:-3.64|P-value:1.78E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.16|P-value:6.61E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.66|P-value:1.06E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.43|P-value:2.56E-4 ID:SGTC_2035|Compound:5154463|FD-Score:5.06|P-value:1.69E-7 ID:SGTC_2052|Compound:5265182|FD-Score:3.30|P-value:4.10E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.22|P-value:1.65E-5 ID:SGTC_2329|Compound:6138490|FD-Score:4.46|P-value:3.35E-6 ID:SGTC_2525|Compound:harmine|FD-Score:3.88|P-value:4.28E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.42|P-value:3.97E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.52|P-value:1.79E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.79|P-value:6.18E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-4.62|P-value:2.63E-6 ID:SGTC_2963|Compound:9082507|FD-Score:-5.27|P-value:9.74E-8 ID:SGTC_3052|Compound:9092717|FD-Score:3.24|P-value:5.03E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.07|P-value:9.05E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-4.59|P-value:3.11E-6 ID:SGTC_3091|Compound:9116372|FD-Score:3.12|P-value:7.70E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-4.76|P-value:1.36E-6 ID:SGTC_3214|Compound:9129694|FD-Score:4.43|P-value:3.87E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.25|P-value:4.80E-4

Top fitness defect scores for YLR218C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.60 5.3 µM 5.81E-37 137 7.79E-37
2 SGTC_1635 st007035 9.23 42.4 µM 1.01E-20 85 1.37E-20
3 SGTC_386 1509-0011 6.91 3.1 µM 1.79E-12 78 2.34E-12
4 SGTC_2035 5154463 5.06 94.6 µM 1.69E-7 3 2.11E-7
5 SGTC_2329 6138490 4.46 200.0 µM 3.35E-6 17 4.12E-6
6 SGTC_3214 9129694 4.43 49.5 µM 3.87E-6 16 4.75E-6
7 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.42 92.6 µM 3.97E-6 17 4.88E-6
8 SGTC_464 bw-b 70c 4.38 158.0 µM 4.88E-6 13 5.99E-6
9 SGTC_1151 3909-8316 4.31 15.3 µM 6.53E-6 11 7.99E-6
10 SGTC_1158 4092-0494 4.19 91.8 µM 1.15E-5 12 1.41E-5
11 SGTC_842 0271-0008 4.04 11.1 µM 2.17E-5 heme biosynthesis & mitochondrial translocase 17 2.64E-5
12 SGTC_2525 harmine 3.88 47.9 µM 4.28E-5 ergosterol biosynthesis 11 5.17E-5
13 SGTC_1023 4482-3888 3.85 16.0 µM 4.86E-5 TSC3-RPN4 20 5.86E-5
14 SGTC_1167 k781-0610 3.80 148.0 µM 5.94E-5 RNA processing & uracil transport 31 7.16E-5
15 SGTC_402 epigallocatechin gallate 3.80 10.0 µM 6.03E-5 32 7.26E-5
16 SGTC_2635 hydroquinidine 3.79 100.0 µM 6.18E-5 27 7.43E-5
17 SGTC_2030 5175110 3.66 200.0 µM 1.06E-4 Golgi 33 1.27E-4
18 SGTC_1163 k060-0048 3.64 49.9 µM 1.13E-4 32 1.35E-4
19 SGTC_310 1273-0058 3.64 1.1 µM 1.14E-4 mitochondrial stress 267 1.36E-4
20 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.53 66.5 µM 1.74E-4 24 2.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.513 2.26E-224 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.509 1.29E-220 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.465 4.67E-180 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.462 9.93E-177 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.461 4.06E-176 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.454 1.27E-170 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.451 4.29E-168 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.451 1.04E-167 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.450 8.77E-167 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.446 8.00E-164 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.445 1.85E-162 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.444 3.12E-162 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.444 1.03E-161 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.436 1.93E-155 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.431 5.43E-152 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit