HIPHOP chemogenomics database

YLR222C / UTP13

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain

fixedexpanded
Profile for YLR222C / UTP13

Click on Significant Values for Screen Details

Top fitness defect scores for YLR222C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_617	3770-0098	8.32	35.0 µM	1.18E-15	exosome	8	4.25E-17	0.44
2	SGTC_2702	st077768	5.92	96.8 µM	8.01E-9		1	1.57E-9	1.26
3	SGTC_800	3448-7362	4.92	155.0 µM	1.29E-6	translation	34	4.31E-7	0.10
4	SGTC_2203	7227154	4.91	166.4 µM	1.39E-6		1	4.66E-7	0.89
5	SGTC_2934	9036370	4.49	36.9 µM	8.71E-6		3	3.52E-6	0.43
6	SGTC_1178	0988-0033	4.48	191.0 µM	9.21E-6		4	3.74E-6	0.30
7	SGTC_572	0960-0087	4.43	17.7 µM	1.13E-5		7	4.67E-6	0.07
8	SGTC_2307	7538926	4.30	6.3 µM	1.91E-5		19	8.35E-6	0.19
9	SGTC_118	0083-0097	4.25	135.3 µM	2.34E-5	translation	14	1.05E-5	0.00
10	SGTC_114	0364-0001	4.18	490.3 µM	3.18E-5		2	1.46E-5	0.07
11	SGTC_549	1661-1316	4.02	519.0 µM	5.86E-5		6	2.87E-5	0.06
12	SGTC_1323	1348-1351	3.89	11.2 µM	9.81E-5		3	5.05E-5	0.09
13	SGTC_724	3910-0327	3.89	137.0 µM	9.92E-5	ERG2	5	5.12E-5	0.14
14	SGTC_626	0214-0009	3.88	33.0 µM	1.03E-4	copper-dependent oxidative stress	3	5.30E-5	0.10
15	SGTC_2058	5236698	3.84	133.0 µM	1.19E-4		4	6.22E-5	0.01
16	SGTC_189	3970-0742	3.81	2.1 µM	1.29E-4		3	6.83E-5	0.57
17	SGTC_2940	9060638	3.67	45.9 µM	2.21E-4	amide catabolism	8	1.23E-4	0.23
18	SGTC_386	1509-0011	3.66	3.1 µM	2.22E-4		9	1.24E-4	0.21
19	SGTC_2266	7929956	3.62	200.0 µM	2.60E-4		7	1.48E-4	0.23
20	SGTC_2339	9000433	3.58	200.0 µM	2.95E-4		7	1.69E-4	0.11

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.220	7.39E-38	YPR137W	RRP9	het	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.214	4.15E-36	YDR064W	RPS13	het	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.180	7.10E-26	YHL015W	RPS20	het	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.179	1.04E-25	YJL069C	UTP18	het	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.178	3.13E-25	YPR136C_d	YPR136C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.161	7.46E-21	YGL123W	RPS2	het	Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.154	3.47E-19	YNL178W	RPS3	het	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.150	2.25E-18	YLR129W	DIP2	het	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.140	3.34E-16	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.138	1.26E-15	YHR069C	RRP4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.137	1.43E-15	YGR095C	RRP46	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.131	2.20E-14	YDR324C	UTP4	het	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.117	1.14E-11	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.114	3.69E-11	YML031W	NDC1	het	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.113	4.83E-11	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)