YLR225C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR225C / YLR225C

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:7.11|P-value:1.92E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.44|P-value:7.01E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:7.43|P-value:2.03E-13 ID:SGTC_176|Compound:1486-1328|FD-Score:4.92|P-value:7.93E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.18|P-value:9.25E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.39|P-value:4.74E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.32|P-value:6.00E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:4.01|P-value:4.50E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:-4.11|P-value:2.93E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.32|P-value:5.75E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.77|P-value:1.19E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.53|P-value:2.76E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.37|P-value:9.96E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.62|P-value:2.11E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.57|P-value:2.51E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.70|P-value:1.56E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.79|P-value:1.46E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-3.87|P-value:7.68E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.32|P-value:6.00E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.20|P-value:9.01E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.62|P-value:1.96E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.54|P-value:2.67E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.26|P-value:7.50E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.91|P-value:6.44E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-5.08|P-value:3.33E-7 ID:SGTC_2362|Compound:9071156|FD-Score:3.41|P-value:4.40E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.28|P-value:6.95E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.76|P-value:9.74E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.16|P-value:9.80E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.16|P-value:9.81E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.87|P-value:7.87E-5 ID:SGTC_3103|Compound:9120822|FD-Score:-4.09|P-value:3.22E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.80|P-value:1.55E-11 ID:SGTC_3264|Compound:9137442|FD-Score:-3.22|P-value:8.26E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.69|P-value:1.57E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.31|P-value:1.28E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.47|P-value:3.56E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:7.11|P-value:1.92E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.44|P-value:7.01E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:7.43|P-value:2.03E-13 ID:SGTC_176|Compound:1486-1328|FD-Score:4.92|P-value:7.93E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.18|P-value:9.25E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.39|P-value:4.74E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.32|P-value:6.00E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:4.01|P-value:4.50E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:-4.11|P-value:2.93E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.32|P-value:5.75E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.77|P-value:1.19E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.53|P-value:2.76E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.37|P-value:9.96E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.62|P-value:2.11E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.57|P-value:2.51E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.70|P-value:1.56E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.79|P-value:1.46E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-3.87|P-value:7.68E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.32|P-value:6.00E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.20|P-value:9.01E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.62|P-value:1.96E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.54|P-value:2.67E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.26|P-value:7.50E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.91|P-value:6.44E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-5.08|P-value:3.33E-7 ID:SGTC_2362|Compound:9071156|FD-Score:3.41|P-value:4.40E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.28|P-value:6.95E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.76|P-value:9.74E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.16|P-value:9.80E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.16|P-value:9.81E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.87|P-value:7.87E-5 ID:SGTC_3103|Compound:9120822|FD-Score:-4.09|P-value:3.22E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.80|P-value:1.55E-11 ID:SGTC_3264|Compound:9137442|FD-Score:-3.22|P-value:8.26E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.69|P-value:1.57E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.31|P-value:1.28E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.47|P-value:3.56E-4

Top fitness defect scores for YLR225C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_165 k038-0023 7.43 64.4 µM 2.03E-13 ubiquinone biosynthesis & proteasome 10 5.38E-14
2 SGTC_161 4065-0411 7.11 162.2 µM 1.92E-12 20 5.66E-13
3 SGTC_3210 9128157 6.80 49.5 µM 1.55E-11 10 5.06E-12
4 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.76 63.6 µM 9.74E-9 16 4.32E-9
5 SGTC_176 1486-1328 4.92 72.8 µM 7.93E-7 33 4.34E-7
6 SGTC_1836 st055642 4.79 81.0 µM 1.46E-6 11 8.23E-7
7 SGTC_1409 3909-8004 4.37 61.9 µM 9.96E-6 6 6.14E-6
8 SGTC_3293 9120939 4.31 62.0 µM 1.28E-5 14 7.99E-6
9 SGTC_425 3825-7017 4.01 13.1 µM 4.50E-5 20 2.98E-5
10 SGTC_2951 9072950 3.87 58.1 µM 7.87E-5 ERG2 25 5.35E-5
11 SGTC_970 1315-0089 3.77 19.5 µM 1.19E-4 RSC & ERG11 27 8.23E-5
12 SGTC_1792 st045773 3.70 43.6 µM 1.56E-4 34 1.10E-4
13 SGTC_3274 9138298 3.69 49.5 µM 1.57E-4 27 1.10E-4
14 SGTC_1773 st048542 3.62 73.6 µM 2.11E-4 55 1.50E-4
15 SGTC_2887 9044784 3.59 58.4 µM 2.32E-4 fatty acid desaturase (OLE1) 47 1.66E-4
16 SGTC_906 1165-0455 3.59 526.0 µM 2.32E-4 19 1.66E-4
17 SGTC_1783 st039459 3.57 87.5 µM 2.51E-4 Golgi 32 1.80E-4
18 SGTC_3349 9149703 3.47 23.0 µM 3.56E-4 24 2.60E-4
19 SGTC_2362 9071156 3.41 126.0 µM 4.40E-4 24 3.24E-4
20 SGTC_326 k292-0812 3.39 17.5 µM 4.74E-4 12 3.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.59E-10 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.100 7.35E-9 YKR046C PET10 hom Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
0.099 9.73E-9 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.098 1.32E-8 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.097 1.61E-8 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.096 2.76E-8 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.094 4.22E-8 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.092 1.03E-7 YJL011C RPC17 het RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress
0.091 1.25E-7 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.088 2.87E-7 YCR084C TUP1 hom General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
0.087 3.86E-7 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.086 6.04E-7 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.084 1.04E-6 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.083 1.64E-6 YFL017C GNA1 het Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
0.082 2.19E-6 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation