YLR226W / BUR2

Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR226W / BUR2

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:3.26|P-value:6.43E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.28|P-value:5.31E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.71|P-value:1.24E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.17|P-value:7.74E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.38|P-value:3.64E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-4.61|P-value:2.15E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.31|P-value:4.73E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.44|P-value:3.46E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.24|P-value:5.98E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.29|P-value:5.90E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.80|P-value:8.64E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.73|P-value:9.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:1.69E-5 ID:SGTC_2902|Compound:5787006|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.47|P-value:3.08E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.38|P-value:4.32E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.93|P-value:4.37E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.17|P-value:8.75E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.16|P-value:7.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.19|P-value:7.21E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.26|P-value:6.43E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.28|P-value:5.31E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.71|P-value:1.24E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.17|P-value:7.74E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.38|P-value:3.64E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-4.61|P-value:2.15E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.31|P-value:4.73E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.44|P-value:3.46E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.24|P-value:5.98E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.29|P-value:5.90E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.80|P-value:8.64E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.73|P-value:9.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:1.69E-5 ID:SGTC_2902|Compound:5787006|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.47|P-value:3.08E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.38|P-value:4.32E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.93|P-value:4.37E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.17|P-value:8.75E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.16|P-value:7.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.19|P-value:7.21E-4

Top fitness defect scores for YLR226W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2195 6536160 3.80 144.2 µM 8.64E-5 60S ribosome export 13 7.16E-5
2 SGTC_174 3553-0389 3.71 74.3 µM 1.24E-4 28 1.04E-4
3 SGTC_2296 7971656 3.66 126.5 µM 1.53E-4 51 1.28E-4
4 SGTC_3059 1327-0034 3.47 3.0 µM 3.08E-4 69 2.61E-4
5 SGTC_1570 verbenone 3.44 133.0 µM 3.46E-4 30 2.94E-4
6 SGTC_2295 7971645 3.43 200.0 µM 3.57E-4 43 3.04E-4
7 SGTC_3094 9117742 3.38 49.5 µM 4.32E-4 43 3.69E-4
8 SGTC_1606 st000094 3.33 49.2 µM 5.00E-4 60S ribosome export 37 4.28E-4
9 SGTC_2902 5787006 3.33 60.5 µM 5.00E-4 Golgi 43 4.28E-4
10 SGTC_1695 st026914 3.29 34.5 µM 5.90E-4 44 5.06E-4
11 SGTC_61 0978-8327 3.26 98.6 µM 6.43E-4 ergosterol biosynthesis 56 5.53E-4
12 SGTC_3238 9133470 3.17 49.5 µM 8.75E-4 33 7.57E-4
13 SGTC_1306 1185-0270 3.07 9.0 µM 0.00123 Golgi 83 0.00107
14 SGTC_2320 7373003 3.05 200.0 µM 0.00132 61 0.00115
15 SGTC_2863 9028737 3.05 58.4 µM 0.00133 24 0.00116
16 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 2.98 15.3 µM 0.00164 95 0.00143
17 SGTC_734 2023-0417 2.96 80.0 µM 0.00175 ergosterol biosynthesis 76 0.00153
18 SGTC_2914 7968218 2.90 45.3 µM 0.00209 38 0.00184
19 SGTC_3337 9144342 2.86 33.5 µM 0.00240 72 0.00212
20 SGTC_3019 9081971 2.85 49.5 µM 0.00246 50 0.00217

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.47E-22 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.119 3.93E-12 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.109 2.67E-10 YLR139C SLS1 hom Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.098 1.23E-8 YLR270W DCS1 hom Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress
0.098 1.45E-8 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.096 2.89E-8 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
0.089 2.22E-7 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.088 3.20E-7 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.087 3.91E-7 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.086 5.43E-7 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.086 6.74E-7 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.085 7.39E-7 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.085 8.65E-7 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.084 1.11E-6 YPL097W MSY1 hom Mitochondrial tyrosyl-tRNA synthetase
0.084 1.25E-6 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern