YLR229C / CDC42

Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR229C / CDC42

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.64|P-value:4.03E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:5.02|P-value:1.47E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.68|P-value:3.42E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.94|P-value:1.42E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.59|P-value:1.12E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.50|P-value:5.50E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:3.90|P-value:1.42E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.36|P-value:8.59E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.97|P-value:1.09E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.46|P-value:7.17E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.42|P-value:7.25E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.92|P-value:1.29E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.34|P-value:9.37E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.44|P-value:6.76E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.51|P-value:5.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.56|P-value:5.20E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-4.04|P-value:9.85E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-5.62|P-value:1.08E-7 ID:SGTC_2023|Compound:5144124|FD-Score:7.23|P-value:8.90E-12 ID:SGTC_2161|Compound:5662504|FD-Score:-3.77|P-value:2.53E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.47|P-value:6.99E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.74|P-value:2.50E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.66|P-value:3.68E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:9.62|P-value:2.09E-19 ID:SGTC_2551|Compound:apiole|FD-Score:5.07|P-value:1.19E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-4.34|P-value:3.15E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.77|P-value:4.60E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.13|P-value:5.95E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.43|P-value:6.97E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-5.59|P-value:1.19E-7 ID:SGTC_2980|Compound:9014342|FD-Score:3.79|P-value:2.10E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.37|P-value:8.33E-4 ID:SGTC_3120|Compound:9124077|FD-Score:9.57|P-value:3.14E-19 ID:SGTC_3141|Compound:9094609|FD-Score:3.46|P-value:6.35E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.37|P-value:8.26E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.58|P-value:4.79E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.40|P-value:8.72E-4 ID:SGTC_3288|Compound:9119690|FD-Score:5.82|P-value:3.08E-8 ID:SGTC_3304|Compound:9125678|FD-Score:20.30|P-value:9.95E-80 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:1.85E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.64|P-value:4.03E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:5.02|P-value:1.47E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.68|P-value:3.42E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.94|P-value:1.42E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.59|P-value:1.12E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.50|P-value:5.50E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:3.90|P-value:1.42E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.36|P-value:8.59E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.97|P-value:1.09E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.46|P-value:7.17E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.42|P-value:7.25E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.92|P-value:1.29E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.34|P-value:9.37E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.44|P-value:6.76E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.51|P-value:5.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.56|P-value:5.20E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-4.04|P-value:9.85E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-5.62|P-value:1.08E-7 ID:SGTC_2023|Compound:5144124|FD-Score:7.23|P-value:8.90E-12 ID:SGTC_2161|Compound:5662504|FD-Score:-3.77|P-value:2.53E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.47|P-value:6.99E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.74|P-value:2.50E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.66|P-value:3.68E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:9.62|P-value:2.09E-19 ID:SGTC_2551|Compound:apiole|FD-Score:5.07|P-value:1.19E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-4.34|P-value:3.15E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.77|P-value:4.60E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.13|P-value:5.95E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.43|P-value:6.97E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-5.59|P-value:1.19E-7 ID:SGTC_2980|Compound:9014342|FD-Score:3.79|P-value:2.10E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.37|P-value:8.33E-4 ID:SGTC_3120|Compound:9124077|FD-Score:9.57|P-value:3.14E-19 ID:SGTC_3141|Compound:9094609|FD-Score:3.46|P-value:6.35E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.37|P-value:8.26E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.58|P-value:4.79E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.40|P-value:8.72E-4 ID:SGTC_3288|Compound:9119690|FD-Score:5.82|P-value:3.08E-8 ID:SGTC_3304|Compound:9125678|FD-Score:20.30|P-value:9.95E-80 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:1.85E-4

Top fitness defect scores for YLR229C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3304 9125678 20.30 46.1 µM 9.95E-80 7 2.81E-92 2.59
2 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 9.62 100.0 µM 2.09E-19 1 3.37E-22 4.75
3 SGTC_3120 9124077 9.57 49.5 µM 3.14E-19 6 5.42E-22 0.06
4 SGTC_2023 5144124 7.23 124.0 µM 8.90E-12 2 2.35E-13 2.39
5 SGTC_3288 9119690 5.82 36.2 µM 3.08E-8 11 2.92E-9 0.18
6 SGTC_2551 apiole 5.07 73.9 µM 1.19E-6 1 1.99E-7 1.13
7 SGTC_132 0417-1715 5.02 25.8 µM 1.47E-6 RPP1 & pyrimidine depletion 6 2.53E-7 0.47
8 SGTC_2597 laccaic acid a 4.77 100.0 µM 4.60E-6 4 9.44E-7 0.17
9 SGTC_2603 homopterocarpin 4.13 100.0 µM 5.95E-5 6 1.80E-5 0.43
10 SGTC_1076 itraconazole 3.97 331.0 nM 1.09E-4 4 3.60E-5 0.01
11 SGTC_1439 4092-1168 3.92 46.0 µM 1.29E-4 1 4.40E-5 0.32
12 SGTC_698 k064-0052 3.90 127.0 µM 1.42E-4 DNA damage response 2 4.88E-5 0.01
13 SGTC_129 0088-0017 3.86 176.6 µM 1.64E-4 4 5.77E-5 0.03
14 SGTC_3316 9136639 3.82 10.6 µM 1.85E-4 5 6.63E-5 0.00
15 SGTC_2980 9014342 3.79 25.3 µM 2.10E-4 20 7.67E-5 0.00
16 SGTC_2540 epiandrosterone 3.74 100.0 µM 2.50E-4 4 9.39E-5 0.05
17 SGTC_1925 st057770 3.51 10.1 µM 5.30E-4 TSC3-RPN4 9 2.22E-4 0.01
18 SGTC_436 n,n-dimethylsphingosine 3.50 3.3 µM 5.50E-4 3 2.31E-4 0.09
19 SGTC_3141 9094609 3.46 49.5 µM 6.35E-4 iron homeostasis 19 2.73E-4 0.00
20 SGTC_1852 st056254 3.44 31.4 µM 6.76E-4 3 2.93E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.587 1.74E-309 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.579 1.95E-299 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.416 2.24E-140 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.388 8.53E-121 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.333 1.49E-87 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.259 1.50E-52 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.193 1.88E-29 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.172 9.29E-24 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.159 2.45E-20 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.148 7.03E-18 YMR068W AVO2 hom Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.146 1.70E-17 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.143 7.93E-17 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.143 8.43E-17 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.140 3.41E-16 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.128 9.76E-14 YOL019W_p YOL019W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication