YLR230W_d

Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR230W / YLR230W

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:4.75|P-value:4.81E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.66|P-value:3.28E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.68|P-value:2.05E-10 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.81|P-value:1.81E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.34|P-value:2.45E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.89|P-value:1.43E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.45|P-value:6.16E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:-3.31|P-value:9.57E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-5.14|P-value:7.47E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:3.82|P-value:1.86E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.64|P-value:3.49E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.41|P-value:7.43E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.54|P-value:1.13E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.97|P-value:1.82E-6 ID:SGTC_1777|Compound:st045864|FD-Score:3.53|P-value:5.06E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-4.62|P-value:7.52E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.34|P-value:8.75E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.03|P-value:7.91E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.96|P-value:1.89E-6 ID:SGTC_2077|Compound:5212015|FD-Score:3.42|P-value:7.15E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.57|P-value:4.34E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.83|P-value:1.66E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.32|P-value:9.25E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.79|P-value:1.90E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.37|P-value:2.29E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.55|P-value:4.69E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:-4.00|P-value:8.86E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.82|P-value:1.88E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.39|P-value:7.84E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.40|P-value:7.27E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.89|P-value:1.46E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.70|P-value:5.97E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-5.04|P-value:1.17E-6 ID:SGTC_2958|Compound:9077254|FD-Score:-4.19|P-value:4.35E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-3.70|P-value:2.66E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-5.52|P-value:1.17E-7 ID:SGTC_3039|Compound:9090270|FD-Score:3.54|P-value:4.87E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.93|P-value:1.91E-6 ID:SGTC_3120|Compound:9124077|FD-Score:18.80|P-value:3.47E-69 ID:SGTC_3211|Compound:9128781|FD-Score:5.97|P-value:1.31E-8 ID:SGTC_3249|Compound:9135183|FD-Score:3.33|P-value:9.48E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-5.02|P-value:1.29E-6 ID:SGTC_3269|Compound:9137823|FD-Score:4.34|P-value:2.62E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.60|P-value:4.02E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.72|P-value:2.41E-4 ID:SGTC_3288|Compound:9119690|FD-Score:15.20|P-value:3.95E-46 ID:SGTC_3304|Compound:9125678|FD-Score:17.70|P-value:5.38E-62 ID:SGTC_3324|Compound:9138759|FD-Score:-3.80|P-value:1.83E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.75|P-value:4.81E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.66|P-value:3.28E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.68|P-value:2.05E-10 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.81|P-value:1.81E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.34|P-value:2.45E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.89|P-value:1.43E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.45|P-value:6.16E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:-3.31|P-value:9.57E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-5.14|P-value:7.47E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:3.82|P-value:1.86E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.64|P-value:3.49E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.41|P-value:7.43E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.54|P-value:1.13E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.97|P-value:1.82E-6 ID:SGTC_1777|Compound:st045864|FD-Score:3.53|P-value:5.06E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-4.62|P-value:7.52E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.34|P-value:8.75E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.03|P-value:7.91E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.96|P-value:1.89E-6 ID:SGTC_2077|Compound:5212015|FD-Score:3.42|P-value:7.15E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.57|P-value:4.34E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.83|P-value:1.66E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.32|P-value:9.25E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.79|P-value:1.90E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.37|P-value:2.29E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.55|P-value:4.69E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:-4.00|P-value:8.86E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.82|P-value:1.88E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.39|P-value:7.84E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.40|P-value:7.27E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.89|P-value:1.46E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.70|P-value:5.97E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-5.04|P-value:1.17E-6 ID:SGTC_2958|Compound:9077254|FD-Score:-4.19|P-value:4.35E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-3.70|P-value:2.66E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-5.52|P-value:1.17E-7 ID:SGTC_3039|Compound:9090270|FD-Score:3.54|P-value:4.87E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.93|P-value:1.91E-6 ID:SGTC_3120|Compound:9124077|FD-Score:18.80|P-value:3.47E-69 ID:SGTC_3211|Compound:9128781|FD-Score:5.97|P-value:1.31E-8 ID:SGTC_3249|Compound:9135183|FD-Score:3.33|P-value:9.48E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-5.02|P-value:1.29E-6 ID:SGTC_3269|Compound:9137823|FD-Score:4.34|P-value:2.62E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.60|P-value:4.02E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.72|P-value:2.41E-4 ID:SGTC_3288|Compound:9119690|FD-Score:15.20|P-value:3.95E-46 ID:SGTC_3304|Compound:9125678|FD-Score:17.70|P-value:5.38E-62 ID:SGTC_3324|Compound:9138759|FD-Score:-3.80|P-value:1.83E-4

Top fitness defect scores for YLR230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3120 9124077 18.80 49.5 µM 3.47E-69 3 5.20E-79 4.16
2 SGTC_3304 9125678 17.70 46.1 µM 5.38E-62 8 8.97E-71 2.30
3 SGTC_3288 9119690 15.20 36.2 µM 3.95E-46 3 1.34E-52 5.28
4 SGTC_3211 9128781 5.97 49.5 µM 1.31E-8 4 1.21E-9 0.12
5 SGTC_1775 st081588 4.97 35.2 µM 1.82E-6 60S ribosome export 8 3.41E-7 0.08
6 SGTC_2038 4100038 4.96 31.0 µM 1.89E-6 plasma membrane duress 9 3.55E-7 0.13
7 SGTC_61 0978-8327 4.75 98.6 µM 4.81E-6 ergosterol biosynthesis 5 1.03E-6 0.57
8 SGTC_2924 9010168 4.70 62.8 µM 5.97E-6 cell wall signaling 2 1.32E-6 0.33
9 SGTC_1714 st033236 4.54 13.6 µM 1.13E-5 4 2.75E-6 0.10
10 SGTC_2569 tetrandrine 4.37 100.0 µM 2.29E-5 1 6.14E-6 0.47
11 SGTC_3269 9137823 4.34 49.5 µM 2.62E-5 60S ribosome export 2 7.15E-6 0.02
12 SGTC_572 0960-0087 3.89 17.7 µM 1.43E-4 12 4.94E-5 0.20
13 SGTC_2877 9040724 3.89 71.4 µM 1.46E-4 3 5.09E-5 0.39
14 SGTC_1092 toremifene 3.82 6.3 µM 1.86E-4 5 6.67E-5 0.17
15 SGTC_2754 granisetron 3.82 64.0 µM 1.88E-4 8 6.75E-5 0.46
16 SGTC_62 0180-0423 3.66 3.2 µM 3.28E-4 60S ribosome export 15 1.28E-4 0.05
17 SGTC_1108 betulinic acid 3.64 729.1 nM 3.49E-4 6 1.37E-4 0.24
18 SGTC_3273 9137859 3.60 49.5 µM 4.02E-4 3 1.61E-4 0.02
19 SGTC_2090 5301565 3.57 104.5 µM 4.34E-4 TSC3-RPN4 9 1.76E-4 0.02
20 SGTC_2639 lactacystin 3.55 53.0 µM 4.69E-4 12 1.91E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.652 0 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.638 0 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.416 2.24E-140 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.377 9.44E-114 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.315 3.00E-78 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.211 5.63E-35 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.203 1.46E-32 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.171 3.15E-23 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.153 6.37E-19 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.139 6.69E-16 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.136 2.83E-15 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.130 4.98E-14 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.128 9.87E-14 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.127 1.29E-13 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.114 3.73E-11 YBR140C IRA1 het GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication