YLR231C / BNA5

Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR231C / BNA5

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:2.84|P-value:8.69E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.05|P-value:4.46E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.99|P-value:5.87E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:3.53|P-value:5.30E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:2.90|P-value:6.86E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.35|P-value:2.48E-9 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.27|P-value:2.48E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.66|P-value:4.73E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:2.96|P-value:5.45E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.17|P-value:2.40E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.05|P-value:4.42E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.23|P-value:2.88E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.13|P-value:2.82E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:7.89E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.25|P-value:1.78E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.51|P-value:5.68E-5 ID:SGTC_1637|Compound:st007924|FD-Score:5.09|P-value:1.30E-8 ID:SGTC_1646|Compound:st011709|FD-Score:-3.19|P-value:3.46E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.71|P-value:3.87E-5 ID:SGTC_1660|Compound:st012960|FD-Score:2.81|P-value:9.83E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.66|P-value:4.80E-5 ID:SGTC_1915|Compound:st067105|FD-Score:2.84|P-value:8.56E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.14|P-value:4.16E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.16|P-value:2.54E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.47|P-value:6.78E-5 ID:SGTC_2278|Compound:7948257|FD-Score:4.54|P-value:3.38E-7 ID:SGTC_2329|Compound:6138490|FD-Score:4.17|P-value:2.37E-6 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:1.76E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-2.92|P-value:9.53E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.16|P-value:2.52E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.04|P-value:6.04E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.62|P-value:3.52E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-2.97|P-value:8.12E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.50|P-value:9.44E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-2.94|P-value:8.83E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.39|P-value:1.34E-6 ID:SGTC_2937|Compound:9044753|FD-Score:3.30|P-value:1.40E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-2.93|P-value:9.27E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.43|P-value:8.17E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-4.83|P-value:1.21E-7 ID:SGTC_3027|Compound:9089541|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_3078|Compound:9116413|FD-Score:2.95|P-value:5.63E-4 ID:SGTC_3338|Compound:9144300|FD-Score:5.19|P-value:7.06E-9 ID:SGTC_3340|Compound:9146634|FD-Score:3.16|P-value:2.49E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:2.84|P-value:8.69E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.05|P-value:4.46E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.99|P-value:5.87E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:3.53|P-value:5.30E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:2.90|P-value:6.86E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:5.35|P-value:2.48E-9 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.27|P-value:2.48E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.66|P-value:4.73E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:2.96|P-value:5.45E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.17|P-value:2.40E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.05|P-value:4.42E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.23|P-value:2.88E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.13|P-value:2.82E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:7.89E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.25|P-value:1.78E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.51|P-value:5.68E-5 ID:SGTC_1637|Compound:st007924|FD-Score:5.09|P-value:1.30E-8 ID:SGTC_1646|Compound:st011709|FD-Score:-3.19|P-value:3.46E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.71|P-value:3.87E-5 ID:SGTC_1660|Compound:st012960|FD-Score:2.81|P-value:9.83E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.66|P-value:4.80E-5 ID:SGTC_1915|Compound:st067105|FD-Score:2.84|P-value:8.56E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.14|P-value:4.16E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.16|P-value:2.54E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.47|P-value:6.78E-5 ID:SGTC_2278|Compound:7948257|FD-Score:4.54|P-value:3.38E-7 ID:SGTC_2329|Compound:6138490|FD-Score:4.17|P-value:2.37E-6 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:1.76E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-2.92|P-value:9.53E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.16|P-value:2.52E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.04|P-value:6.04E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.62|P-value:3.52E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-2.97|P-value:8.12E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.50|P-value:9.44E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-2.94|P-value:8.83E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.39|P-value:1.34E-6 ID:SGTC_2937|Compound:9044753|FD-Score:3.30|P-value:1.40E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-2.93|P-value:9.27E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.43|P-value:8.17E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-4.83|P-value:1.21E-7 ID:SGTC_3027|Compound:9089541|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_3078|Compound:9116413|FD-Score:2.95|P-value:5.63E-4 ID:SGTC_3338|Compound:9144300|FD-Score:5.19|P-value:7.06E-9 ID:SGTC_3340|Compound:9146634|FD-Score:3.16|P-value:2.49E-4

Top fitness defect scores for YLR231C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_343 4130-2827 5.35 29.8 µM 2.48E-9 10 4.42E-8
2 SGTC_3338 9144300 5.19 39.6 µM 7.06E-9 Golgi 7 1.07E-7
3 SGTC_1637 st007924 5.09 17.4 µM 1.30E-8 11 1.80E-7
4 SGTC_2278 7948257 4.54 134.3 µM 3.38E-7 15 2.87E-6
5 SGTC_2329 6138490 4.17 200.0 µM 2.37E-6 23 1.50E-5
6 SGTC_728 3030-5151 4.05 22.5 µM 4.42E-6 11 2.54E-5
7 SGTC_145 3737-0113 4.05 38.4 µM 4.46E-6 DNA intercalators 71 2.57E-5
8 SGTC_175 3793-3120 3.99 23.7 µM 5.87E-6 14 3.24E-5
9 SGTC_2540 epiandrosterone 3.62 100.0 µM 3.52E-5 70 1.48E-4
10 SGTC_184 1494-0393 3.53 24.7 µM 5.30E-5 81 2.10E-4
11 SGTC_1472 k841-0093 3.51 193.0 µM 5.68E-5 31 2.23E-4
12 SGTC_2267 7931562 3.47 200.0 µM 6.78E-5 35 2.59E-4
13 SGTC_1365 1672-3266 3.44 55.4 µM 7.89E-5 41 2.94E-4
14 SGTC_2968 9090663 3.43 33.4 µM 8.17E-5 51 3.03E-4
15 SGTC_1467 k284-1082 3.32 293.0 µM 1.29E-4 34 4.47E-4
16 SGTC_2937 9044753 3.30 11.3 µM 1.40E-4 60S ribosome export 59 4.78E-4
17 SGTC_3027 9089541 3.29 49.5 µM 1.49E-4 fatty acid desaturase (OLE1) 44 5.06E-4
18 SGTC_2784 7567673 3.29 72.7 µM 1.49E-4 iron homeostasis 56 5.06E-4
19 SGTC_2378 9074213 3.25 121.4 µM 1.76E-4 RSC complex & mRNA processing 47 5.81E-4
20 SGTC_1426 4048-4480 3.25 71.7 µM 1.78E-4 60S ribosome export 40 5.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.02E-9 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.097 1.79E-8 YOR320C GNT1 hom N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
0.094 5.22E-8 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.37E-7 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.088 3.42E-7 YLR050C_p YLR050C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
0.086 7.12E-7 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
0.085 8.48E-7 YHL035C VMR1 hom Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
0.084 9.94E-7 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.084 1.10E-6 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.083 1.45E-6 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.083 1.68E-6 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.082 2.19E-6 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.37E-6 YLL055W YCT1 hom High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
0.080 3.06E-6 YKL123W_d YKL123W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
0.080 3.17E-6 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases