YLR232W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR232W / YLR232W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.58|P-value:1.88E-20 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.01|P-value:6.32E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.89|P-value:1.36E-10 ID:SGTC_116|Compound:0155-0182|FD-Score:3.82|P-value:2.11E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.14|P-value:4.56E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.14|P-value:3.76E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.60|P-value:4.27E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.21|P-value:2.98E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.23|P-value:2.63E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.43|P-value:1.17E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.42|P-value:1.27E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.37|P-value:1.50E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.47|P-value:1.01E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.84|P-value:1.88E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.58|P-value:6.25E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.64|P-value:4.78E-5 ID:SGTC_1717|Compound:st033143|FD-Score:4.09|P-value:5.69E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.24|P-value:2.62E-4 ID:SGTC_1750|Compound:st081859|FD-Score:2.91|P-value:9.17E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.48|P-value:9.38E-5 ID:SGTC_1792|Compound:st045773|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.39|P-value:1.40E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.34|P-value:1.69E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.25|P-value:2.44E-4 ID:SGTC_2021|Compound:4019055|FD-Score:2.99|P-value:6.60E-4 ID:SGTC_2143|Compound:5623677|FD-Score:4.22|P-value:3.02E-6 ID:SGTC_2149|Compound:5554786|FD-Score:3.72|P-value:3.34E-5 ID:SGTC_2152|Compound:5568786|FD-Score:-4.06|P-value:6.97E-6 ID:SGTC_2155|Compound:5570423|FD-Score:-7.20|P-value:6.17E-15 ID:SGTC_2198|Compound:6589944|FD-Score:2.93|P-value:8.33E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.37|P-value:1.52E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.37|P-value:1.49E-4 ID:SGTC_2324|Compound:6149169|FD-Score:2.93|P-value:8.32E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.16|P-value:3.46E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_2396|Compound:5342950|FD-Score:6.12|P-value:2.73E-11 ID:SGTC_2404|Compound:5161160|FD-Score:-3.00|P-value:6.62E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.40|P-value:1.37E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.89|P-value:9.54E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-6.11|P-value:3.01E-11 ID:SGTC_2784|Compound:7567673|FD-Score:5.97|P-value:7.71E-11 ID:SGTC_2815|Compound:7968870|FD-Score:-4.92|P-value:6.99E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:8.58|P-value:1.88E-20 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.01|P-value:6.32E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.89|P-value:1.36E-10 ID:SGTC_116|Compound:0155-0182|FD-Score:3.82|P-value:2.11E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.14|P-value:4.56E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.14|P-value:3.76E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.60|P-value:4.27E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.21|P-value:2.98E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.23|P-value:2.63E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.43|P-value:1.17E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.42|P-value:1.27E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.37|P-value:1.50E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.47|P-value:1.01E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.84|P-value:1.88E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.58|P-value:6.25E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.64|P-value:4.78E-5 ID:SGTC_1717|Compound:st033143|FD-Score:4.09|P-value:5.69E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.24|P-value:2.62E-4 ID:SGTC_1750|Compound:st081859|FD-Score:2.91|P-value:9.17E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.48|P-value:9.38E-5 ID:SGTC_1792|Compound:st045773|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.39|P-value:1.40E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.34|P-value:1.69E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.25|P-value:2.44E-4 ID:SGTC_2021|Compound:4019055|FD-Score:2.99|P-value:6.60E-4 ID:SGTC_2143|Compound:5623677|FD-Score:4.22|P-value:3.02E-6 ID:SGTC_2149|Compound:5554786|FD-Score:3.72|P-value:3.34E-5 ID:SGTC_2152|Compound:5568786|FD-Score:-4.06|P-value:6.97E-6 ID:SGTC_2155|Compound:5570423|FD-Score:-7.20|P-value:6.17E-15 ID:SGTC_2198|Compound:6589944|FD-Score:2.93|P-value:8.33E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.37|P-value:1.52E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.37|P-value:1.49E-4 ID:SGTC_2324|Compound:6149169|FD-Score:2.93|P-value:8.32E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.16|P-value:3.46E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_2396|Compound:5342950|FD-Score:6.12|P-value:2.73E-11 ID:SGTC_2404|Compound:5161160|FD-Score:-3.00|P-value:6.62E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.40|P-value:1.37E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.89|P-value:9.54E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-6.11|P-value:3.01E-11 ID:SGTC_2784|Compound:7567673|FD-Score:5.97|P-value:7.71E-11 ID:SGTC_2815|Compound:7968870|FD-Score:-4.92|P-value:6.99E-8

Top fitness defect scores for YLR232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.58 9.0 µM 1.88E-20 cell wall 109 4.75E-18
2 SGTC_2396 5342950 6.12 42.8 µM 2.73E-11 RSC complex & mRNA processing 13 4.73E-10
3 SGTC_2784 7567673 5.97 72.7 µM 7.71E-11 iron homeostasis 6 1.17E-9
4 SGTC_103 0844-0104 5.89 51.8 µM 1.36E-10 ERAD & cell cycle 79 1.92E-9
5 SGTC_2143 5623677 4.22 140.5 µM 3.02E-6 2 1.22E-5
6 SGTC_138 0850-0259 4.14 40.9 µM 4.56E-6 cell wall 189 1.75E-5
7 SGTC_1717 st033143 4.09 58.0 µM 5.69E-6 37 2.12E-5
8 SGTC_1607 st000305 3.84 50.6 µM 1.88E-5 15 6.04E-5
9 SGTC_116 0155-0182 3.82 31.8 µM 2.11E-5 mitochondrial response to ROS 89 6.69E-5
10 SGTC_2149 5554786 3.72 194.8 µM 3.34E-5 cell wall signaling 45 1.00E-4
11 SGTC_1707 st032323 3.64 6.3 µM 4.78E-5 DNA damage response 70 1.37E-4
12 SGTC_1616 st002734 3.58 56.1 µM 6.25E-5 42 1.73E-4
13 SGTC_1791 st048313 3.48 56.1 µM 9.38E-5 30 2.48E-4
14 SGTC_373 0844-0104 3.43 25.9 µM 1.17E-4 ERAD & cell cycle 73 3.01E-4
15 SGTC_2310 7668677 3.37 200.0 µM 1.49E-4 59 3.71E-4
16 SGTC_1218 1348-1416 3.37 30.7 µM 1.50E-4 SWF1 & branched chain AA biosynthesis 34 3.73E-4
17 SGTC_2309 7664088 3.37 163.9 µM 1.52E-4 73 3.78E-4
18 SGTC_2004 4023728 3.34 41.9 µM 1.69E-4 53 4.16E-4
19 SGTC_2335 9018011 3.32 154.2 µM 1.84E-4 46 4.46E-4
20 SGTC_2009 4012297 3.25 12.1 µM 2.44E-4 cell wall signaling 97 5.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.43E-48 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.246 2.33E-47 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.237 5.94E-44 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.221 2.12E-38 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.220 5.86E-38 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.215 2.78E-36 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.214 4.03E-36 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.206 1.48E-33 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.203 1.52E-32 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.200 1.09E-31 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.196 1.70E-30 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.196 2.15E-30 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.196 2.18E-30 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.196 2.48E-30 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.192 4.24E-29 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough