YLR236C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR236C / YLR236C

Click on Significant Values for Screen Details ID:SGTC_288|Compound:1315-0019|FD-Score:-2.88|P-value:8.75E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-2.88|P-value:8.65E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.27|P-value:2.07E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.13|P-value:3.43E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.01|P-value:5.75E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.39|P-value:1.27E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.02|P-value:5.29E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:6.24|P-value:7.51E-12 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.53|P-value:6.31E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.46|P-value:6.64E-7 ID:SGTC_1049|Compound:3226-0134|FD-Score:-4.61|P-value:2.85E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.26|P-value:2.04E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.26|P-value:1.86E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.84|P-value:1.70E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.89|P-value:1.30E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.59|P-value:5.30E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.15|P-value:3.43E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.17|P-value:2.94E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-2.90|P-value:8.12E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-4.26|P-value:1.94E-6 ID:SGTC_1892|Compound:st058411|FD-Score:3.45|P-value:9.68E-5 ID:SGTC_2014|Compound:4013930|FD-Score:4.00|P-value:7.98E-6 ID:SGTC_2016|Compound:5121758|FD-Score:4.53|P-value:4.94E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.85|P-value:1.59E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.03|P-value:5.01E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.58|P-value:5.18E-5 ID:SGTC_2097|Compound:5376186|FD-Score:-3.58|P-value:5.05E-5 ID:SGTC_2110|Compound:5483698|FD-Score:2.87|P-value:9.92E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.11|P-value:3.60E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:2.97|P-value:6.75E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.95|P-value:6.68E-4 ID:SGTC_2314|Compound:7727897|FD-Score:2.98|P-value:6.41E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.87|P-value:1.48E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.77|P-value:2.33E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-4.73|P-value:1.41E-7 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.56|P-value:6.08E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.17|P-value:3.10E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.94|P-value:9.71E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.42|P-value:1.14E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.18|P-value:2.98E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.11|P-value:3.99E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.50|P-value:5.78E-7 ID:SGTC_2954|Compound:9074818|FD-Score:5.37|P-value:3.25E-9 ID:SGTC_2991|Compound:9074669|FD-Score:-2.99|P-value:5.93E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.55|P-value:6.33E-5 ID:SGTC_3101|Compound:9120531|FD-Score:5.25|P-value:7.08E-9 ID:SGTC_3105|Compound:9121040|FD-Score:4.95|P-value:4.35E-8 ID:SGTC_3108|Compound:9121785|FD-Score:3.32|P-value:1.66E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.31|P-value:1.79E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.96|P-value:7.10E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.85|P-value:1.45E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.12|P-value:3.58E-4 ID:SGTC_3213|Compound:9129884|FD-Score:7.87|P-value:8.80E-18 ID:SGTC_3216|Compound:9129716|FD-Score:6.37|P-value:2.87E-12 ID:SGTC_3271|Compound:9137798|FD-Score:-4.03|P-value:6.18E-6 ID:SGTC_3276|Compound:9139060|FD-Score:3.05|P-value:4.96E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.04|P-value:5.18E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-2.88|P-value:8.75E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-2.88|P-value:8.65E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.27|P-value:2.07E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.13|P-value:3.43E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.01|P-value:5.75E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.39|P-value:1.27E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.02|P-value:5.29E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:6.24|P-value:7.51E-12 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.53|P-value:6.31E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.46|P-value:6.64E-7 ID:SGTC_1049|Compound:3226-0134|FD-Score:-4.61|P-value:2.85E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.26|P-value:2.04E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.26|P-value:1.86E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.84|P-value:1.70E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.89|P-value:1.30E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.59|P-value:5.30E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.15|P-value:3.43E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.17|P-value:2.94E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-2.90|P-value:8.12E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-4.26|P-value:1.94E-6 ID:SGTC_1892|Compound:st058411|FD-Score:3.45|P-value:9.68E-5 ID:SGTC_2014|Compound:4013930|FD-Score:4.00|P-value:7.98E-6 ID:SGTC_2016|Compound:5121758|FD-Score:4.53|P-value:4.94E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.85|P-value:1.59E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.03|P-value:5.01E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.58|P-value:5.18E-5 ID:SGTC_2097|Compound:5376186|FD-Score:-3.58|P-value:5.05E-5 ID:SGTC_2110|Compound:5483698|FD-Score:2.87|P-value:9.92E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-3.11|P-value:3.60E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:2.97|P-value:6.75E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.95|P-value:6.68E-4 ID:SGTC_2314|Compound:7727897|FD-Score:2.98|P-value:6.41E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.87|P-value:1.48E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.77|P-value:2.33E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-4.73|P-value:1.41E-7 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.56|P-value:6.08E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.17|P-value:3.10E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.94|P-value:9.71E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.42|P-value:1.14E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.18|P-value:2.98E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.11|P-value:3.99E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.50|P-value:5.78E-7 ID:SGTC_2954|Compound:9074818|FD-Score:5.37|P-value:3.25E-9 ID:SGTC_2991|Compound:9074669|FD-Score:-2.99|P-value:5.93E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.55|P-value:6.33E-5 ID:SGTC_3101|Compound:9120531|FD-Score:5.25|P-value:7.08E-9 ID:SGTC_3105|Compound:9121040|FD-Score:4.95|P-value:4.35E-8 ID:SGTC_3108|Compound:9121785|FD-Score:3.32|P-value:1.66E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.31|P-value:1.79E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.96|P-value:7.10E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.85|P-value:1.45E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.12|P-value:3.58E-4 ID:SGTC_3213|Compound:9129884|FD-Score:7.87|P-value:8.80E-18 ID:SGTC_3216|Compound:9129716|FD-Score:6.37|P-value:2.87E-12 ID:SGTC_3271|Compound:9137798|FD-Score:-4.03|P-value:6.18E-6 ID:SGTC_3276|Compound:9139060|FD-Score:3.05|P-value:4.96E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.04|P-value:5.18E-4

Top fitness defect scores for YLR236C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3213 9129884 7.87 49.5 µM 8.80E-18 2 1.78E-15
2 SGTC_3216 9129716 6.37 49.5 µM 2.87E-12 RPP1 & pyrimidine depletion 5 9.42E-11
3 SGTC_940 3232-1287 6.24 54.8 µM 7.51E-12 NEO1 9 2.15E-10
4 SGTC_2954 9074818 5.37 52.7 µM 3.25E-9 17 3.93E-8
5 SGTC_3101 9120531 5.25 49.5 µM 7.08E-9 12 7.67E-8
6 SGTC_3105 9121040 4.95 49.5 µM 4.35E-8 4 3.65E-7
7 SGTC_2016 5121758 4.53 140.0 µM 4.94E-7 redox potentiating 29 2.95E-6
8 SGTC_2823 7987624 4.50 58.4 µM 5.78E-7 16 3.37E-6
9 SGTC_2014 4013930 4.00 200.0 µM 7.98E-6 29 3.23E-5
10 SGTC_1474 0330-0125 3.89 5.3 µM 1.30E-5 31 4.92E-5
11 SGTC_2471 5466956 3.87 24.8 µM 1.48E-5 mitochondrial processes 13 5.49E-5
12 SGTC_2049 5262831 3.85 67.2 µM 1.59E-5 30 5.84E-5
13 SGTC_1453 4237-0541 3.84 195.0 µM 1.70E-5 heme biosynthesis & mitochondrial translocase 31 6.19E-5
14 SGTC_2511 berberine 3.77 10.5 µM 2.33E-5 60S ribosome export 21 8.13E-5
15 SGTC_1569 carminic acid 3.59 40.6 µM 5.30E-5 28 1.65E-4
16 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.56 100.0 µM 6.08E-5 49 1.86E-4
17 SGTC_3045 9092950 3.55 49.5 µM 6.33E-5 26 1.92E-4
18 SGTC_1892 st058411 3.45 7.4 µM 9.68E-5 44 2.78E-4
19 SGTC_2645 abamectin 3.42 100.0 µM 1.14E-4 heme requiring 48 3.19E-4
20 SGTC_591 4299-0174 3.39 154.0 µM 1.27E-4 19 3.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.07E-9 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.097 1.60E-8 YLR454W_p FMP27_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.093 6.79E-8 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.083 1.35E-6 YCL026C-B HBN1 hom Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.083 1.57E-6 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.083 1.66E-6 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.082 1.93E-6 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.081 2.68E-6 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.080 3.46E-6 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.079 4.72E-6 YNL327W EGT2 hom Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
0.078 5.59E-6 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.072 2.62E-5 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.072 3.32E-5 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.070 5.03E-5 YNL050C_p YNL050C_p hom Putative protein of unknown function; YNL050c is not an essential gene
0.070 5.43E-5 YCR073W-A SOL2 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication