YLR237W / THI7

Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR237W / THI7

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-4.89|P-value:4.52E-6 ID:SGTC_82|Compound:0054-0107|FD-Score:4.04|P-value:1.24E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.41|P-value:9.88E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.51|P-value:7.37E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:10.70|P-value:1.05E-22 ID:SGTC_656|Compound:4090-1979|FD-Score:4.20|P-value:7.10E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.26|P-value:5.52E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.70|P-value:3.89E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.45|P-value:2.70E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.47|P-value:7.97E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.51|P-value:2.18E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.08|P-value:1.10E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.08|P-value:1.03E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.00|P-value:1.38E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.73|P-value:3.52E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.60|P-value:5.56E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.81|P-value:6.60E-6 ID:SGTC_2790|Compound:5423970|FD-Score:3.62|P-value:5.23E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.61|P-value:5.35E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.58|P-value:5.95E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.89|P-value:4.52E-6 ID:SGTC_82|Compound:0054-0107|FD-Score:4.04|P-value:1.24E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.41|P-value:9.88E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.51|P-value:7.37E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:10.70|P-value:1.05E-22 ID:SGTC_656|Compound:4090-1979|FD-Score:4.20|P-value:7.10E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.26|P-value:5.52E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.70|P-value:3.89E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.45|P-value:2.70E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.47|P-value:7.97E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.51|P-value:2.18E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.08|P-value:1.10E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.08|P-value:1.03E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.00|P-value:1.38E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.73|P-value:3.52E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.60|P-value:5.56E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.81|P-value:6.60E-6 ID:SGTC_2790|Compound:5423970|FD-Score:3.62|P-value:5.23E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.61|P-value:5.35E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.58|P-value:5.95E-4

Top fitness defect scores for YLR237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 10.70 9.4 µM 1.05E-22 3 3.48E-27
2 SGTC_2762 leflunomide 4.81 42.1 µM 6.60E-6 11 7.68E-7
3 SGTC_1254 0550-0035 4.51 264.0 µM 2.18E-5 11 3.25E-6
4 SGTC_1157 4092-0394 4.45 27.6 µM 2.70E-5 20 4.20E-6
5 SGTC_656 4090-1979 4.20 187.0 µM 7.10E-5 11 1.35E-5
6 SGTC_1256 0570-0116 4.08 285.0 µM 1.10E-4 16 2.27E-5
7 SGTC_82 0054-0107 4.04 293.8 µM 1.24E-4 8 2.64E-5
8 SGTC_2790 5423970 3.62 71.4 µM 5.23E-4 endomembrane recycling 84 1.49E-4
9 SGTC_2979 9012552 3.61 45.5 µM 5.35E-4 14 1.53E-4
10 SGTC_1548 st061468 3.60 90.8 µM 5.56E-4 14 1.60E-4
11 SGTC_2987 9018338 3.58 71.4 µM 5.95E-4 RPP1 & pyrimidine depletion 34 1.74E-4
12 SGTC_356 1634-0012 3.51 32.5 µM 7.37E-4 35 2.25E-4
13 SGTC_260 nsc-65238 3.41 4.0 µM 9.88E-4 endomembrane recycling 29 3.19E-4
14 SGTC_2503 beta-caryophyllene alcohol 3.38 24.7 µM 0.00108 19 3.57E-4
15 SGTC_909 3448-9333 3.32 149.0 µM 0.00130 34 4.44E-4
16 SGTC_1633 st005664 3.32 67.9 µM 0.00132 65 4.53E-4
17 SGTC_781 4335-2806 3.21 94.4 µM 0.00183 44 6.67E-4
18 SGTC_840 0245-0196 3.19 390.0 µM 0.00194 37 7.15E-4
19 SGTC_1546 5-methoxyflavanone 3.16 78.7 µM 0.00209 33 7.82E-4
20 SGTC_293 4049-0273 3.16 38.5 µM 0.00209 39 7.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 2.54E-44 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.220 7.13E-38 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.171 2.66E-23 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.166 4.68E-22 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.159 2.18E-20 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.158 4.49E-20 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.149 3.86E-18 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.144 6.59E-17 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.133 1.31E-14 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.127 1.89E-13 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.120 3.36E-12 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.117 8.75E-12 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.116 1.67E-11 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.116 1.67E-11 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.114 3.08E-11 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product