YLR238W / FAR10

Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR238W / FAR10

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.60|P-value:1.38E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.32|P-value:4.26E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.12|P-value:8.25E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.07|P-value:2.06E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.09|P-value:9.11E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.31|P-value:4.25E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.53|P-value:2.50E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:4.64|P-value:1.44E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:3.11|P-value:8.56E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.93|P-value:2.00E-12 ID:SGTC_641|Compound:4092-0595|FD-Score:3.11|P-value:8.56E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.51|P-value:1.48E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:3.33|P-value:3.95E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.95|P-value:3.11E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.91|P-value:3.99E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.29|P-value:1.20E-10 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.79|P-value:6.56E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.51|P-value:2.76E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.38|P-value:3.21E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.40|P-value:3.01E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.56|P-value:2.03E-11 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.93|P-value:3.66E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.78|P-value:6.88E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.27|P-value:4.83E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.17|P-value:1.51E-5 ID:SGTC_1740|Compound:st038286|FD-Score:4.14|P-value:1.49E-5 ID:SGTC_1982|Compound:st072467|FD-Score:-3.49|P-value:2.44E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.14|P-value:7.55E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.70|P-value:9.37E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.20|P-value:6.52E-35 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.25|P-value:7.54E-8 ID:SGTC_2707|Compound:st078556|FD-Score:3.87|P-value:4.81E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.40|P-value:2.97E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.35|P-value:4.08E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:1.22E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.54|P-value:1.80E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.27|P-value:4.82E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.10|P-value:1.78E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.49|P-value:3.08E-6 ID:SGTC_3066|Compound:9117245|FD-Score:5.76|P-value:3.35E-9 ID:SGTC_3069|Compound:9117009|FD-Score:3.91|P-value:4.09E-5 ID:SGTC_3075|Compound:9116269|FD-Score:4.29|P-value:7.73E-6 ID:SGTC_3097|Compound:9117246|FD-Score:3.16|P-value:7.12E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.23|P-value:6.34E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.72|P-value:8.70E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.60|P-value:1.38E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.32|P-value:4.26E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.12|P-value:8.25E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.07|P-value:2.06E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.09|P-value:9.11E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.31|P-value:4.25E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.53|P-value:2.50E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:4.64|P-value:1.44E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:3.11|P-value:8.56E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.93|P-value:2.00E-12 ID:SGTC_641|Compound:4092-0595|FD-Score:3.11|P-value:8.56E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.51|P-value:1.48E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:3.33|P-value:3.95E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.95|P-value:3.11E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.91|P-value:3.99E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.29|P-value:1.20E-10 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.79|P-value:6.56E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.51|P-value:2.76E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.38|P-value:3.21E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.40|P-value:3.01E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.56|P-value:2.03E-11 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.93|P-value:3.66E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.78|P-value:6.88E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.27|P-value:4.83E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.17|P-value:1.51E-5 ID:SGTC_1740|Compound:st038286|FD-Score:4.14|P-value:1.49E-5 ID:SGTC_1982|Compound:st072467|FD-Score:-3.49|P-value:2.44E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.14|P-value:7.55E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.70|P-value:9.37E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.20|P-value:6.52E-35 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.25|P-value:7.54E-8 ID:SGTC_2707|Compound:st078556|FD-Score:3.87|P-value:4.81E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.40|P-value:2.97E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.35|P-value:4.08E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:1.22E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.54|P-value:1.80E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.27|P-value:4.82E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.10|P-value:1.78E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.49|P-value:3.08E-6 ID:SGTC_3066|Compound:9117245|FD-Score:5.76|P-value:3.35E-9 ID:SGTC_3069|Compound:9117009|FD-Score:3.91|P-value:4.09E-5 ID:SGTC_3075|Compound:9116269|FD-Score:4.29|P-value:7.73E-6 ID:SGTC_3097|Compound:9117246|FD-Score:3.16|P-value:7.12E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.23|P-value:6.34E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.72|P-value:8.70E-5

Top fitness defect scores for YLR238W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 12.20 100.0 µM 6.52E-35 redox potentiating 38 1.42E-34
2 SGTC_1161 k007-0610 6.56 110.0 µM 2.03E-11 ERAD & cell cycle 47 2.70E-11
3 SGTC_1026 k007-1105 6.29 30.6 µM 1.20E-10 ERAD & cell cycle 38 1.57E-10
4 SGTC_3066 9117245 5.76 49.5 µM 3.35E-9 3 4.24E-9
5 SGTC_689 0833-0039 5.51 98.0 µM 1.48E-8 ergosterol depletion effects on membrane 16 1.84E-8
6 SGTC_64 000l-0018 5.32 272.1 µM 4.26E-8 ubiquinone biosynthesis & proteasome 99 5.26E-8
7 SGTC_805 3852-0218 4.95 479.0 µM 3.11E-7 ERAD & cell cycle 37 3.75E-7
8 SGTC_258 haloperidol 4.64 50.8 µM 1.44E-6 fatty acid desaturase (OLE1) 19 1.71E-6
9 SGTC_227 fluconazole 4.53 33.5 µM 2.50E-6 azole & statin 63 2.96E-6
10 SGTC_1040 k898-0338 4.51 155.0 µM 2.76E-6 14 3.26E-6
11 SGTC_3063 1327-0034 4.49 4.0 µM 3.08E-6 36 3.64E-6
12 SGTC_3075 9116269 4.29 49.5 µM 7.73E-6 14 9.03E-6
13 SGTC_1740 st038286 4.14 13.2 µM 1.49E-5 23 1.73E-5
14 SGTC_1556 plumbagin 4.12 1.5 µM 1.64E-5 superoxide 17 1.90E-5
15 SGTC_3056 9094900 4.10 49.5 µM 1.78E-5 19 2.06E-5
16 SGTC_158 k038-0087 4.07 26.4 µM 2.06E-5 ubiquinone biosynthesis & proteasome 130 2.38E-5
17 SGTC_1199 1638-0010 3.93 4.5 µM 3.66E-5 endomembrane recycling 24 4.20E-5
18 SGTC_849 0386-0493 3.91 241.0 µM 3.99E-5 20 4.57E-5
19 SGTC_3069 9117009 3.91 49.5 µM 4.09E-5 60S ribosome export 7 4.69E-5
20 SGTC_2707 st078556 3.87 66.6 µM 4.81E-5 12 5.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.337 5.52E-90 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.318 9.52E-80 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.292 6.33E-67 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.287 7.69E-65 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.280 2.85E-61 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.248 3.79E-48 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.245 4.89E-47 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.244 7.48E-47 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.242 8.50E-46 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.241 1.53E-45 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.240 2.41E-45 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.235 1.76E-43 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.234 6.69E-43 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.232 4.09E-42 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.230 1.51E-41 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p