YLR239C / LIP2

Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR239C / LIP2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:7.16|P-value:1.20E-9 ID:SGTC_18|Compound:0111-0177|FD-Score:5.86|P-value:5.85E-7 ID:SGTC_34|Compound:0469-0683|FD-Score:6.91|P-value:4.33E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:8.58|P-value:3.55E-13 ID:SGTC_47|Compound:0149-0135|FD-Score:5.02|P-value:1.70E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:8.18|P-value:4.22E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:10.30|P-value:2.71E-18 ID:SGTC_64|Compound:000l-0018|FD-Score:22.40|P-value:2.13E-80 ID:SGTC_67|Compound:0335-0847|FD-Score:8.90|P-value:4.83E-14 ID:SGTC_73|Compound:0327-0325|FD-Score:5.68|P-value:1.28E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.80|P-value:3.82E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.68|P-value:5.84E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:6.22|P-value:1.20E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.20|P-value:2.88E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.95|P-value:6.07E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:5.51|P-value:2.53E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:5.44|P-value:3.40E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.25|P-value:2.46E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.38|P-value:1.62E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.09|P-value:4.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.40|P-value:1.20E-29 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.84|P-value:2.98E-11 ID:SGTC_279|Compound:1273-0055|FD-Score:3.96|P-value:5.93E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.80|P-value:9.60E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.60|P-value:7.73E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:5.20|P-value:8.80E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.79|P-value:3.91E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:10.20|P-value:4.30E-18 ID:SGTC_783|Compound:0848-0141|FD-Score:6.91|P-value:4.44E-9 ID:SGTC_847|Compound:0342-0274|FD-Score:5.68|P-value:1.24E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:6.50|P-value:3.32E-8 ID:SGTC_856|Compound:0433-0016|FD-Score:4.74|P-value:4.71E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:7.46|P-value:2.46E-10 ID:SGTC_969|Compound:1313-0238|FD-Score:4.36|P-value:1.72E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.50|P-value:1.06E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.07|P-value:4.30E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.04|P-value:4.70E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.06|P-value:1.69E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.67|P-value:1.30E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.89|P-value:7.39E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.49|P-value:1.11E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.87|P-value:7.84E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.48|P-value:1.16E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.31|P-value:2.02E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.25|P-value:7.11E-6 ID:SGTC_1635|Compound:st007035|FD-Score:12.40|P-value:1.11E-25 ID:SGTC_1672|Compound:st016598|FD-Score:4.11|P-value:3.82E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.97|P-value:2.03E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.43|P-value:4.55E-8 ID:SGTC_1687|Compound:st020778|FD-Score:6.02|P-value:2.95E-7 ID:SGTC_1703|Compound:st026983|FD-Score:3.82|P-value:8.89E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.12|P-value:1.16E-5 ID:SGTC_1856|Compound:st057054|FD-Score:5.50|P-value:2.66E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-4.22|P-value:9.77E-5 ID:SGTC_2043|Compound:5101342|FD-Score:5.64|P-value:1.51E-6 ID:SGTC_2147|Compound:5545932|FD-Score:4.74|P-value:4.66E-5 ID:SGTC_2270|Compound:7924575|FD-Score:5.49|P-value:2.72E-6 ID:SGTC_2274|Compound:7947094|FD-Score:4.26|P-value:2.35E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.80|P-value:9.53E-4 ID:SGTC_2475|Compound:5812728|FD-Score:6.09|P-value:2.19E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:5.12|P-value:1.18E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.36|P-value:1.72E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.81|P-value:9.23E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.16|P-value:3.20E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-4.17|P-value:1.15E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.12|P-value:1.18E-5 ID:SGTC_2833|Compound:9001315|FD-Score:7.08|P-value:1.90E-9 ID:SGTC_2841|Compound:9004761|FD-Score:4.02|P-value:4.92E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.84|P-value:8.44E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.57|P-value:7.69E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.33|P-value:1.90E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.35|P-value:1.78E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.14|P-value:3.46E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:7.16|P-value:1.20E-9 ID:SGTC_18|Compound:0111-0177|FD-Score:5.86|P-value:5.85E-7 ID:SGTC_34|Compound:0469-0683|FD-Score:6.91|P-value:4.33E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:8.58|P-value:3.55E-13 ID:SGTC_47|Compound:0149-0135|FD-Score:5.02|P-value:1.70E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:8.18|P-value:4.22E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:10.30|P-value:2.71E-18 ID:SGTC_64|Compound:000l-0018|FD-Score:22.40|P-value:2.13E-80 ID:SGTC_67|Compound:0335-0847|FD-Score:8.90|P-value:4.83E-14 ID:SGTC_73|Compound:0327-0325|FD-Score:5.68|P-value:1.28E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.80|P-value:3.82E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.68|P-value:5.84E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:6.22|P-value:1.20E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.20|P-value:2.88E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.95|P-value:6.07E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:5.51|P-value:2.53E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:5.44|P-value:3.40E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.25|P-value:2.46E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.38|P-value:1.62E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.09|P-value:4.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.40|P-value:1.20E-29 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.84|P-value:2.98E-11 ID:SGTC_279|Compound:1273-0055|FD-Score:3.96|P-value:5.93E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.80|P-value:9.60E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.60|P-value:7.73E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:5.20|P-value:8.80E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.79|P-value:3.91E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:10.20|P-value:4.30E-18 ID:SGTC_783|Compound:0848-0141|FD-Score:6.91|P-value:4.44E-9 ID:SGTC_847|Compound:0342-0274|FD-Score:5.68|P-value:1.24E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:6.50|P-value:3.32E-8 ID:SGTC_856|Compound:0433-0016|FD-Score:4.74|P-value:4.71E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:7.46|P-value:2.46E-10 ID:SGTC_969|Compound:1313-0238|FD-Score:4.36|P-value:1.72E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.50|P-value:1.06E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.07|P-value:4.30E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.04|P-value:4.70E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.06|P-value:1.69E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.67|P-value:1.30E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.89|P-value:7.39E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.49|P-value:1.11E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.87|P-value:7.84E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.48|P-value:1.16E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.31|P-value:2.02E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.25|P-value:7.11E-6 ID:SGTC_1635|Compound:st007035|FD-Score:12.40|P-value:1.11E-25 ID:SGTC_1672|Compound:st016598|FD-Score:4.11|P-value:3.82E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.97|P-value:2.03E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.43|P-value:4.55E-8 ID:SGTC_1687|Compound:st020778|FD-Score:6.02|P-value:2.95E-7 ID:SGTC_1703|Compound:st026983|FD-Score:3.82|P-value:8.89E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.12|P-value:1.16E-5 ID:SGTC_1856|Compound:st057054|FD-Score:5.50|P-value:2.66E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-4.22|P-value:9.77E-5 ID:SGTC_2043|Compound:5101342|FD-Score:5.64|P-value:1.51E-6 ID:SGTC_2147|Compound:5545932|FD-Score:4.74|P-value:4.66E-5 ID:SGTC_2270|Compound:7924575|FD-Score:5.49|P-value:2.72E-6 ID:SGTC_2274|Compound:7947094|FD-Score:4.26|P-value:2.35E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.80|P-value:9.53E-4 ID:SGTC_2475|Compound:5812728|FD-Score:6.09|P-value:2.19E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:5.12|P-value:1.18E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.36|P-value:1.72E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.81|P-value:9.23E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.16|P-value:3.20E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-4.17|P-value:1.15E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.12|P-value:1.18E-5 ID:SGTC_2833|Compound:9001315|FD-Score:7.08|P-value:1.90E-9 ID:SGTC_2841|Compound:9004761|FD-Score:4.02|P-value:4.92E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.84|P-value:8.44E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.57|P-value:7.69E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.33|P-value:1.90E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.35|P-value:1.78E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.14|P-value:3.46E-4

Top fitness defect scores for YLR239C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 22.40 272.1 µM 2.13E-80 ubiquinone biosynthesis & proteasome 7 1.41E-111
2 SGTC_236 1509-0011 13.40 5.3 µM 1.20E-29 131 4.90E-41
3 SGTC_1635 st007035 12.40 42.4 µM 1.11E-25 54 1.64E-35
4 SGTC_59 0330-0160 10.30 1.3 µM 2.71E-18 9 3.29E-25
5 SGTC_778 3456-2434 10.20 196.0 µM 4.30E-18 mitochondrial response to ROS 5 6.24E-25
6 SGTC_67 0335-0847 8.90 266.0 µM 4.83E-14 ubiquinone biosynthesis & proteasome 31 2.83E-19
7 SGTC_36 0335-0881 8.58 14.2 µM 3.55E-13 ubiquinone biosynthesis & proteasome 31 4.58E-18
8 SGTC_54 0159-0055 8.18 9.0 µM 4.22E-12 ERG2 12 1.46E-16
9 SGTC_275 trichlorophene 7.84 5.7 µM 2.98E-11 mitochondrial stress 79 2.24E-15
10 SGTC_902 1120-0002 7.46 2.1 µM 2.46E-10 azole & statin 10 4.28E-14
11 SGTC_7 0192-1582 7.16 4.2 µM 1.20E-9 15 3.93E-13
12 SGTC_2833 9001315 7.08 45.5 µM 1.90E-9 amide catabolism 9 7.46E-13
13 SGTC_34 0469-0683 6.91 81.8 µM 4.33E-9 SWF1 & branched chain AA biosynthesis 5 2.37E-12
14 SGTC_783 0848-0141 6.91 92.7 µM 4.44E-9 RSC & ERG11 1 2.46E-12
15 SGTC_852 0418-0143 6.50 439.0 µM 3.32E-8 calcium & mitochondrial duress 22 4.10E-11
16 SGTC_1681 tripelennamine 6.43 100.0 µM 4.55E-8 3 6.37E-11
17 SGTC_116 0155-0182 6.22 31.8 µM 1.20E-7 mitochondrial response to ROS 22 2.47E-10
18 SGTC_2475 5812728 6.09 15.0 µM 2.19E-7 mitochondrial processes 4 5.77E-10
19 SGTC_1687 st020778 6.02 55.4 µM 2.95E-7 110 8.74E-10
20 SGTC_18 0111-0177 5.86 500.0 nM 5.85E-7 22 2.28E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.464 1.46E-178 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.461 3.25E-176 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.451 1.02E-167 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.438 2.08E-157 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.423 4.10E-146 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.416 2.44E-140 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.415 5.09E-140 YOR196C LIP5 hom Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.404 1.07E-131 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.396 1.63E-126 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.374 5.80E-112 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.370 2.13E-109 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.369 1.09E-108 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.366 1.44E-106 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.343 2.40E-93 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.337 4.54E-90 YOR221C MCT1 hom Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling