YLR240W / VPS34

Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR240W / VPS34

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.09|P-value:7.08E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.22|P-value:4.59E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.34|P-value:4.18E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.36|P-value:4.13E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.26|P-value:5.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:1.78E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.57|P-value:1.21E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.29|P-value:3.52E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.26|P-value:3.90E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.84|P-value:6.47E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:4.27|P-value:9.97E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.55|P-value:1.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.19|P-value:5.05E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.68|P-value:1.21E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.78|P-value:8.19E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.28|P-value:9.36E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.44|P-value:3.08E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.77|P-value:8.42E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.67|P-value:4.90E-12 ID:SGTC_993|Compound:3909-8757|FD-Score:3.59|P-value:1.71E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.70|P-value:1.28E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.26|P-value:6.74E-8 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.17|P-value:8.00E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.71|P-value:1.08E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.26|P-value:5.86E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.84|P-value:6.38E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.36|P-value:6.66E-6 ID:SGTC_1731|Compound:st035964|FD-Score:-3.32|P-value:3.17E-4 ID:SGTC_1893|Compound:st059353|FD-Score:5.37|P-value:3.78E-8 ID:SGTC_1905|Compound:st060207|FD-Score:4.70|P-value:1.27E-6 ID:SGTC_1909|Compound:st060837|FD-Score:5.23|P-value:8.24E-8 ID:SGTC_1979|Compound:st071809|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.99|P-value:3.42E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.89|P-value:4.88E-7 ID:SGTC_2111|Compound:5486399|FD-Score:3.55|P-value:2.00E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.12|P-value:9.78E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-4.06|P-value:1.53E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.64|P-value:9.13E-5 ID:SGTC_2431|Compound:5490079|FD-Score:4.12|P-value:1.95E-5 ID:SGTC_2445|Compound:5742597|FD-Score:5.47|P-value:2.11E-8 ID:SGTC_2513|Compound:baicalein|FD-Score:4.32|P-value:7.99E-6 ID:SGTC_2523|Compound:spermine|FD-Score:3.60|P-value:1.67E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.32|P-value:7.84E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.40|P-value:3.57E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.74|P-value:6.04E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.73|P-value:6.37E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.13|P-value:9.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.94|P-value:2.11E-7 ID:SGTC_2960|Compound:9079389|FD-Score:5.76|P-value:3.92E-9 ID:SGTC_2964|Compound:9083345|FD-Score:-5.49|P-value:9.50E-9 ID:SGTC_2973|Compound:9094665|FD-Score:-5.35|P-value:2.20E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.36|P-value:2.72E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.52|P-value:1.46E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-4.83|P-value:3.79E-7 ID:SGTC_3128|Compound:9127691|FD-Score:-7.57|P-value:5.64E-15 ID:SGTC_57|Compound:miconazole|FD-Score:-3.09|P-value:7.08E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.22|P-value:4.59E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.34|P-value:4.18E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.36|P-value:4.13E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.26|P-value:5.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:1.78E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.57|P-value:1.21E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.29|P-value:3.52E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.26|P-value:3.90E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.84|P-value:6.47E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:4.27|P-value:9.97E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.55|P-value:1.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.19|P-value:5.05E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.68|P-value:1.21E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.78|P-value:8.19E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.28|P-value:9.36E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.44|P-value:3.08E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.77|P-value:8.42E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.67|P-value:4.90E-12 ID:SGTC_993|Compound:3909-8757|FD-Score:3.59|P-value:1.71E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.70|P-value:1.28E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.26|P-value:6.74E-8 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.17|P-value:8.00E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.71|P-value:1.08E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.26|P-value:5.86E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.84|P-value:6.38E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.36|P-value:6.66E-6 ID:SGTC_1731|Compound:st035964|FD-Score:-3.32|P-value:3.17E-4 ID:SGTC_1893|Compound:st059353|FD-Score:5.37|P-value:3.78E-8 ID:SGTC_1905|Compound:st060207|FD-Score:4.70|P-value:1.27E-6 ID:SGTC_1909|Compound:st060837|FD-Score:5.23|P-value:8.24E-8 ID:SGTC_1979|Compound:st071809|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.99|P-value:3.42E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.89|P-value:4.88E-7 ID:SGTC_2111|Compound:5486399|FD-Score:3.55|P-value:2.00E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.12|P-value:9.78E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-4.06|P-value:1.53E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.64|P-value:9.13E-5 ID:SGTC_2431|Compound:5490079|FD-Score:4.12|P-value:1.95E-5 ID:SGTC_2445|Compound:5742597|FD-Score:5.47|P-value:2.11E-8 ID:SGTC_2513|Compound:baicalein|FD-Score:4.32|P-value:7.99E-6 ID:SGTC_2523|Compound:spermine|FD-Score:3.60|P-value:1.67E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.32|P-value:7.84E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.40|P-value:3.57E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.74|P-value:6.04E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.73|P-value:6.37E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.13|P-value:9.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.94|P-value:2.11E-7 ID:SGTC_2960|Compound:9079389|FD-Score:5.76|P-value:3.92E-9 ID:SGTC_2964|Compound:9083345|FD-Score:-5.49|P-value:9.50E-9 ID:SGTC_2973|Compound:9094665|FD-Score:-5.35|P-value:2.20E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.36|P-value:2.72E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.52|P-value:1.46E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-4.83|P-value:3.79E-7 ID:SGTC_3128|Compound:9127691|FD-Score:-7.57|P-value:5.64E-15

Top fitness defect scores for YLR240W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2960 9079389 5.76 6.0 µM 3.92E-9 6 4.26E-9
2 SGTC_2445 5742597 5.47 35.6 µM 2.11E-8 14 2.24E-8
3 SGTC_1893 st059353 5.37 36.1 µM 3.78E-8 7 3.98E-8
4 SGTC_1266 0828-0227 5.26 32.9 µM 6.74E-8 4 7.03E-8
5 SGTC_1909 st060837 5.23 51.5 µM 8.24E-8 24 8.57E-8
6 SGTC_2082 5219693 4.89 150.0 µM 4.88E-7 RNA processing & uracil transport 9 4.95E-7
7 SGTC_351 caspofungin 4.84 25.0 nM 6.47E-7 cell wall 60 6.55E-7
8 SGTC_1905 st060207 4.70 84.5 µM 1.27E-6 3 1.27E-6
9 SGTC_1022 4477-0945 4.70 21.3 µM 1.28E-6 10 1.29E-6
10 SGTC_1574 spiramycin 4.36 23.7 µM 6.66E-6 17 6.55E-6
11 SGTC_2526 patulin 4.32 37.6 µM 7.84E-6 71 7.70E-6
12 SGTC_2513 baicalein 4.32 25.6 µM 7.99E-6 calcium & mitochondrial duress 21 7.84E-6
13 SGTC_638 3970-0837 4.28 4.1 µM 9.36E-6 27 9.17E-6
14 SGTC_356 1634-0012 4.27 32.5 µM 9.97E-6 19 9.75E-6
15 SGTC_2431 5490079 4.12 200.0 µM 1.95E-5 28 1.89E-5
16 SGTC_1985 st071382 3.99 65.5 µM 3.42E-5 18 3.30E-5
17 SGTC_1547 harmine 3.84 94.2 µM 6.38E-5 ergosterol biosynthesis 46 6.12E-5
18 SGTC_511 blebbistatin 3.78 171.0 µM 8.19E-5 DNA intercalators 25 7.84E-5
19 SGTC_842 0271-0008 3.77 11.1 µM 8.42E-5 heme biosynthesis & mitochondrial translocase 23 8.06E-5
20 SGTC_1510 1123-0200 3.71 71.5 µM 1.08E-4 52 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.35E-20 YLR396C VPS33 hom ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole
0.133 1.12E-14 YLR148W PEP3 hom Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
0.104 1.61E-9 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.096 2.32E-8 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.091 1.25E-7 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.091 1.31E-7 YJR090C GRR1 hom F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
0.089 2.47E-7 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.088 3.67E-7 YLR217W_d YLR217W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
0.087 4.45E-7 YJL117W PHO86 hom Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress
0.083 1.30E-6 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.081 2.51E-6 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.081 2.93E-6 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.080 3.51E-6 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.079 4.96E-6 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.079 5.17E-6 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses