YLR241W_p

Putative protein of unknown function, may be involved in detoxification

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR241W / YLR241W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.29|P-value:1.69E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.07|P-value:4.23E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-2.86|P-value:9.23E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.06|P-value:4.38E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.29|P-value:1.70E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.80|P-value:1.82E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.46|P-value:8.46E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.07|P-value:4.82E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:2.86|P-value:9.47E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:2.95|P-value:6.77E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.31|P-value:1.34E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.49|P-value:5.26E-7 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.67|P-value:3.27E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.52|P-value:6.32E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.16|P-value:2.92E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.62|P-value:4.18E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.47|P-value:8.02E-5 ID:SGTC_1740|Compound:st038286|FD-Score:6.43|P-value:1.35E-12 ID:SGTC_1746|Compound:st038117|FD-Score:4.25|P-value:1.90E-6 ID:SGTC_1779|Compound:st039427|FD-Score:4.30|P-value:1.42E-6 ID:SGTC_1812|Compound:st052057|FD-Score:-2.96|P-value:6.51E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.55|P-value:5.61E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.42|P-value:9.97E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.41|P-value:1.05E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.17|P-value:2.91E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.41|P-value:1.02E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.02|P-value:6.22E-6 ID:SGTC_2591|Compound:skatole|FD-Score:3.20|P-value:2.50E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.09|P-value:3.93E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-2.97|P-value:6.08E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.44|P-value:8.98E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-2.90|P-value:7.88E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.64|P-value:3.73E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.18|P-value:2.71E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.18|P-value:2.65E-6 ID:SGTC_3124|Compound:9127567|FD-Score:4.32|P-value:1.31E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.10|P-value:3.72E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.18|P-value:2.74E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.36|P-value:1.02E-6 ID:SGTC_3328|Compound:9140624|FD-Score:6.55|P-value:5.12E-13 ID:SGTC_3335|Compound:9143315|FD-Score:4.10|P-value:4.08E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.29|P-value:1.69E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.07|P-value:4.23E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-2.86|P-value:9.23E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.06|P-value:4.38E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.29|P-value:1.70E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.80|P-value:1.82E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.46|P-value:8.46E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.07|P-value:4.82E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:2.86|P-value:9.47E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:2.95|P-value:6.77E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.31|P-value:1.34E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.49|P-value:5.26E-7 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.67|P-value:3.27E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.52|P-value:6.32E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.16|P-value:2.92E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.62|P-value:4.18E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.47|P-value:8.02E-5 ID:SGTC_1740|Compound:st038286|FD-Score:6.43|P-value:1.35E-12 ID:SGTC_1746|Compound:st038117|FD-Score:4.25|P-value:1.90E-6 ID:SGTC_1779|Compound:st039427|FD-Score:4.30|P-value:1.42E-6 ID:SGTC_1812|Compound:st052057|FD-Score:-2.96|P-value:6.51E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.55|P-value:5.61E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.42|P-value:9.97E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.41|P-value:1.05E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.17|P-value:2.91E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.41|P-value:1.02E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.02|P-value:6.22E-6 ID:SGTC_2591|Compound:skatole|FD-Score:3.20|P-value:2.50E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.09|P-value:3.93E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-2.97|P-value:6.08E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.44|P-value:8.98E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-2.90|P-value:7.88E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.64|P-value:3.73E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.18|P-value:2.71E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.18|P-value:2.65E-6 ID:SGTC_3124|Compound:9127567|FD-Score:4.32|P-value:1.31E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.10|P-value:3.72E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.18|P-value:2.74E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.36|P-value:1.02E-6 ID:SGTC_3328|Compound:9140624|FD-Score:6.55|P-value:5.12E-13 ID:SGTC_3335|Compound:9143315|FD-Score:4.10|P-value:4.08E-6

Top fitness defect scores for YLR241W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3328 9140624 6.55 29.0 µM 5.12E-13 3 2.86E-11
2 SGTC_1740 st038286 6.43 13.2 µM 1.35E-12 3 6.48E-11
3 SGTC_1204 4049-0315 4.49 18.3 µM 5.26E-7 15 3.61E-6
4 SGTC_3325 9138760 4.36 55.2 µM 1.02E-6 Golgi 18 6.36E-6
5 SGTC_3124 9127567 4.32 49.5 µM 1.31E-6 DNA damage response 12 7.86E-6
6 SGTC_1779 st039427 4.30 55.0 µM 1.42E-6 17 8.41E-6
7 SGTC_1746 st038117 4.25 42.0 µM 1.90E-6 22 1.07E-5
8 SGTC_3015 9080845 4.18 49.5 µM 2.65E-6 6 1.43E-5
9 SGTC_1906 st060206 4.17 94.7 µM 2.91E-6 16 1.55E-5
10 SGTC_3335 9143315 4.10 29.6 µM 4.08E-6 fatty acid desaturase (OLE1) 13 2.06E-5
11 SGTC_2587 piperic acid 4.02 92.2 µM 6.22E-6 23 2.95E-5
12 SGTC_1241 0364-0022 3.52 50.8 µM 6.32E-5 ERG2 45 2.13E-4
13 SGTC_1540 guanosine 3.47 70.6 µM 8.02E-5 15 2.61E-4
14 SGTC_621 3584-0052 3.46 32.1 µM 8.46E-5 34 2.73E-4
15 SGTC_1881 5652484 3.42 16.0 µM 9.97E-5 TRP & mitochondrial translation 45 3.14E-4
16 SGTC_2583 asiatic acid 3.41 100.0 µM 1.02E-4 58 3.20E-4
17 SGTC_1903 st060211 3.41 78.3 µM 1.05E-4 47 3.29E-4
18 SGTC_6 0844-0013 3.29 19.8 µM 1.69E-4 163 4.93E-4
19 SGTC_2591 skatole 3.20 100.0 µM 2.50E-4 53 6.89E-4
20 SGTC_3138 9097216 3.18 49.5 µM 2.69E-4 40 7.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 4.42E-32 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.140 4.36E-16 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.134 5.62E-15 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.133 1.03E-14 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.133 1.11E-14 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.132 1.59E-14 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.129 6.65E-14 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.128 8.36E-14 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.125 3.63E-13 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.123 1.03E-12 YDR508C GNP1 hom High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication
0.119 5.39E-12 YGR221C TOS2 hom Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
0.117 1.08E-11 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.117 1.21E-11 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.12E-11 YDR402C DIT2 hom N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
0.114 3.75E-11 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase