YLR244C / MAP1

Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR244C / MAP1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.61|P-value:3.66E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:5.44|P-value:1.77E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.32|P-value:9.39E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.93|P-value:1.43E-8 ID:SGTC_345|Compound:1362-0200|FD-Score:4.27|P-value:3.19E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:7.95|P-value:5.02E-14 ID:SGTC_408|Compound:cantharidin|FD-Score:3.87|P-value:1.47E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.22|P-value:5.28E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.37|P-value:8.21E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.94|P-value:1.93E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:3.74|P-value:2.32E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.23|P-value:3.78E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:5.51|P-value:1.30E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.69|P-value:2.80E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.21|P-value:4.09E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.88|P-value:1.41E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.31|P-value:9.86E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.39|P-value:7.52E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.95|P-value:1.10E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.63|P-value:3.47E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.48|P-value:5.70E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.26|P-value:3.28E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.71|P-value:2.63E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-5.14|P-value:7.46E-7 ID:SGTC_1873|Compound:rapamycin|FD-Score:-4.26|P-value:3.30E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-4.12|P-value:5.83E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.88|P-value:1.44E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.71|P-value:2.54E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.88|P-value:1.41E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.45|P-value:6.36E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.55|P-value:1.02E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.42|P-value:6.90E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.38|P-value:7.85E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.47|P-value:1.42E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.50|P-value:5.23E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.03|P-value:8.31E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-3.38|P-value:7.76E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-5.12|P-value:8.10E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-3.76|P-value:2.16E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.92|P-value:1.49E-8 ID:SGTC_2936|Compound:9038235|FD-Score:-3.82|P-value:1.76E-4 ID:SGTC_3024|Compound:9090631|FD-Score:-3.51|P-value:5.05E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.59|P-value:3.92E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.61|P-value:3.66E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:5.44|P-value:1.77E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.32|P-value:9.39E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.93|P-value:1.43E-8 ID:SGTC_345|Compound:1362-0200|FD-Score:4.27|P-value:3.19E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:7.95|P-value:5.02E-14 ID:SGTC_408|Compound:cantharidin|FD-Score:3.87|P-value:1.47E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.22|P-value:5.28E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.37|P-value:8.21E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.94|P-value:1.93E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:3.74|P-value:2.32E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.23|P-value:3.78E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:5.51|P-value:1.30E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.69|P-value:2.80E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.21|P-value:4.09E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.88|P-value:1.41E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.31|P-value:9.86E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.39|P-value:7.52E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.95|P-value:1.10E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.63|P-value:3.47E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.48|P-value:5.70E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.26|P-value:3.28E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.71|P-value:2.63E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-5.14|P-value:7.46E-7 ID:SGTC_1873|Compound:rapamycin|FD-Score:-4.26|P-value:3.30E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-4.12|P-value:5.83E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.88|P-value:1.44E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.71|P-value:2.54E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.88|P-value:1.41E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.45|P-value:6.36E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.55|P-value:1.02E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.42|P-value:6.90E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.38|P-value:7.85E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.47|P-value:1.42E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.50|P-value:5.23E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.03|P-value:8.31E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-3.38|P-value:7.76E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-5.12|P-value:8.10E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-3.76|P-value:2.16E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.92|P-value:1.49E-8 ID:SGTC_2936|Compound:9038235|FD-Score:-3.82|P-value:1.76E-4 ID:SGTC_3024|Compound:9090631|FD-Score:-3.51|P-value:5.05E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.59|P-value:3.92E-4

Top fitness defect scores for YLR244C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_404 fumagillin 7.95 50.0 µM 5.02E-14 1 9.07E-16
2 SGTC_341 1486-1430 5.93 230.0 µM 1.43E-8 5 1.49E-9
3 SGTC_1064 honokiol 5.51 6.8 µM 1.30E-7 7 1.83E-8
4 SGTC_99 0109-0120 5.44 622.8 µM 1.77E-7 1 2.61E-8
5 SGTC_625 k213-0058 5.22 121.0 µM 5.28E-7 translation 53 9.04E-8
6 SGTC_2028 5153890 4.55 36.4 µM 1.02E-5 cell wall signaling 24 2.64E-6
7 SGTC_1534 6-azauridine 4.38 81.6 µM 2.13E-5 RNA pol III & RNase P/MRP 13 6.05E-6
8 SGTC_345 1362-0200 4.27 395.0 µM 3.19E-5 11 9.56E-6
9 SGTC_1051 3253-3903 4.23 78.0 µM 3.78E-5 18 1.16E-5
10 SGTC_1100 amiodarone 4.21 5.1 µM 4.09E-5 11 1.27E-5
11 SGTC_2769 toremifene 4.03 3.7 µM 8.31E-5 21 2.84E-5
12 SGTC_1174 0739-0097 3.88 51.1 µM 1.41E-4 redox potentiating 36 5.18E-5
13 SGTC_1887 st057648 3.88 70.8 µM 1.44E-4 17 5.29E-5
14 SGTC_408 cantharidin 3.87 100.0 µM 1.47E-4 cell wall signaling 23 5.42E-5
15 SGTC_989 1501-0895 3.74 10.3 µM 2.32E-4 12 9.12E-5
16 SGTC_1806 st050005 3.71 60.3 µM 2.63E-4 15 1.05E-4
17 SGTC_1098 clofazimine 3.69 15.1 µM 2.80E-4 heme biosynthesis & mitochondrial translocase 33 1.13E-4
18 SGTC_1257 0669-0121 3.63 16.0 µM 3.47E-4 38 1.44E-4
19 SGTC_2762 leflunomide 3.50 42.1 µM 5.23E-4 48 2.29E-4
20 SGTC_1730 st033808 3.48 45.1 µM 5.70E-4 55 2.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.86E-20 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.141 3.00E-16 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.107 5.16E-10 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.105 1.06E-9 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.12E-9 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.100 6.20E-9 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.093 8.47E-8 YBL077W_d YBL077W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
0.092 1.08E-7 YMR142C RPL13B hom Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication
0.090 2.04E-7 YPR072W NOT5 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.090 2.09E-7 YGL076C RPL7A hom Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
0.087 4.20E-7 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.087 5.04E-7 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.086 6.02E-7 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.084 1.03E-6 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.083 1.47E-6 YGR081C SLX9 hom Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant