YLR246W / ERF2

Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR246W / ERF2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.00|P-value:3.92E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.02|P-value:3.66E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:2.80|P-value:8.52E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:2.80|P-value:8.50E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.34|P-value:9.26E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:2.90|P-value:5.92E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.88|P-value:6.41E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:2.98|P-value:4.31E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.96|P-value:4.67E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.32|P-value:9.33E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.09|P-value:2.69E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:5.14|P-value:4.25E-9 ID:SGTC_515|Compound:4092-1064|FD-Score:3.54|P-value:3.66E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:4.33|P-value:6.16E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.18|P-value:1.75E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.84|P-value:8.42E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.41|P-value:6.79E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.57|P-value:3.21E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.18|P-value:1.69E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:2.80|P-value:8.72E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.92|P-value:5.60E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.54|P-value:3.58E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.53|P-value:3.83E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.86|P-value:7.19E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.68|P-value:1.69E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.79|P-value:9.87E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.76|P-value:9.32E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.77|P-value:1.19E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-4.16|P-value:1.41E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.90|P-value:6.13E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.88|P-value:6.20E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:2.76|P-value:9.98E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.36|P-value:8.52E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:-4.36|P-value:4.72E-7 ID:SGTC_1590|Compound:st077108|FD-Score:3.05|P-value:3.21E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.79|P-value:8.26E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.93|P-value:5.24E-6 ID:SGTC_1656|Compound:st012921|FD-Score:4.13|P-value:1.83E-6 ID:SGTC_1659|Compound:st012954|FD-Score:2.77|P-value:9.71E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.54|P-value:3.70E-5 ID:SGTC_1697|Compound:st025554|FD-Score:2.90|P-value:5.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.92|P-value:5.25E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.80|P-value:7.98E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.79|P-value:9.08E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-4.05|P-value:2.62E-6 ID:SGTC_2308|Compound:7584454|FD-Score:-2.84|P-value:6.89E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.53|P-value:3.82E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.77|P-value:9.24E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-2.80|P-value:8.12E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-2.84|P-value:7.00E-4 ID:SGTC_2981|Compound:9013952|FD-Score:2.82|P-value:7.84E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.39|P-value:6.76E-5 ID:SGTC_3098|Compound:9119039|FD-Score:-3.31|P-value:9.60E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_3260|Compound:9137109|FD-Score:5.49|P-value:3.78E-10 ID:SGTC_3266|Compound:9136860|FD-Score:3.23|P-value:1.45E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.00|P-value:3.92E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.02|P-value:3.66E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:2.80|P-value:8.52E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:2.80|P-value:8.50E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.34|P-value:9.26E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:2.90|P-value:5.92E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.88|P-value:6.41E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:2.98|P-value:4.31E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.96|P-value:4.67E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.32|P-value:9.33E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.09|P-value:2.69E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:5.14|P-value:4.25E-9 ID:SGTC_515|Compound:4092-1064|FD-Score:3.54|P-value:3.66E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:4.33|P-value:6.16E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.18|P-value:1.75E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.84|P-value:8.42E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.41|P-value:6.79E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.57|P-value:3.21E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.18|P-value:1.69E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:2.80|P-value:8.72E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.92|P-value:5.60E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.54|P-value:3.58E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.53|P-value:3.83E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.86|P-value:7.19E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.68|P-value:1.69E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.79|P-value:9.87E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.76|P-value:9.32E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.77|P-value:1.19E-5 ID:SGTC_1335|Compound:1486-0900|FD-Score:-4.16|P-value:1.41E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.90|P-value:6.13E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.88|P-value:6.20E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:2.76|P-value:9.98E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.36|P-value:8.52E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:-4.36|P-value:4.72E-7 ID:SGTC_1590|Compound:st077108|FD-Score:3.05|P-value:3.21E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.79|P-value:8.26E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.93|P-value:5.24E-6 ID:SGTC_1656|Compound:st012921|FD-Score:4.13|P-value:1.83E-6 ID:SGTC_1659|Compound:st012954|FD-Score:2.77|P-value:9.71E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.54|P-value:3.70E-5 ID:SGTC_1697|Compound:st025554|FD-Score:2.90|P-value:5.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.92|P-value:5.25E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.80|P-value:7.98E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.79|P-value:9.08E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-4.05|P-value:2.62E-6 ID:SGTC_2308|Compound:7584454|FD-Score:-2.84|P-value:6.89E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.53|P-value:3.82E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.77|P-value:9.24E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-2.80|P-value:8.12E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-2.84|P-value:7.00E-4 ID:SGTC_2981|Compound:9013952|FD-Score:2.82|P-value:7.84E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.39|P-value:6.76E-5 ID:SGTC_3098|Compound:9119039|FD-Score:-3.31|P-value:9.60E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_3260|Compound:9137109|FD-Score:5.49|P-value:3.78E-10 ID:SGTC_3266|Compound:9136860|FD-Score:3.23|P-value:1.45E-4

Top fitness defect scores for YLR246W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3260 9137109 5.49 49.5 µM 3.78E-10 60S ribosome export 3 2.03E-8
2 SGTC_477 mead ethanolamide 5.14 10.0 µM 4.25E-9 1 1.40E-7
3 SGTC_597 k018-0003 4.33 82.8 µM 6.16E-7 RNA pol III & RNase P/MRP 8 7.54E-6
4 SGTC_1656 st012921 4.13 11.0 µM 1.83E-6 27 1.81E-5
5 SGTC_1646 st011709 3.93 75.6 µM 5.24E-6 9 4.20E-5
6 SGTC_876 0720-0963 3.92 56.8 µM 5.60E-6 15 4.43E-5
7 SGTC_1338 1486-1223 3.90 76.0 µM 6.13E-6 25 4.77E-5
8 SGTC_615 k087-0205 3.84 167.0 µM 8.42E-6 11 6.15E-5
9 SGTC_1332 1480-0653 3.77 17.5 µM 1.19E-5 TSC3-RPN4 17 8.10E-5
10 SGTC_760 0568-0725 3.57 82.9 µM 3.21E-5 17 1.81E-4
11 SGTC_879 0831-1030 3.54 162.0 µM 3.58E-5 64 1.97E-4
12 SGTC_515 4092-1064 3.54 102.0 µM 3.66E-5 plasma membrane duress 73 2.01E-4
13 SGTC_1691 st019933 3.54 84.6 µM 3.70E-5 22 2.02E-4
14 SGTC_2309 7664088 3.53 163.9 µM 3.82E-5 60 2.08E-4
15 SGTC_927 2425-1185 3.53 123.0 µM 3.83E-5 42 2.08E-4
16 SGTC_617 3770-0098 3.41 35.0 µM 6.79E-5 exosome 26 3.30E-4
17 SGTC_1485 3909-9022 3.36 254.0 µM 8.52E-5 RPP1 & pyrimidine depletion 22 3.96E-4
18 SGTC_284 0988-0104 3.34 32.6 µM 9.26E-5 heme requiring 23 4.23E-4
19 SGTC_3266 9136860 3.23 49.5 µM 1.45E-4 cell wall 72 6.09E-4
20 SGTC_355 1311-2252 3.12 105.0 µM 2.37E-4 58 9.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.68E-8 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.080 4.00E-6 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.070 4.52E-5 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.066 1.21E-4 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.065 1.51E-4 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.064 2.22E-4 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.063 2.47E-4 YER111C SWI4 hom DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
0.062 3.19E-4 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.061 4.33E-4 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.061 4.56E-4 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.058 7.33E-4 YJR068W RFC2 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.058 8.09E-4 YHR001W-A QCR10 hom Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
0.058 8.24E-4 YIR031C DAL7 hom Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.056 0.00116 YCR045C RRT12 hom Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores
0.056 0.00120 YDR493W MZM1 hom Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog