YLR253W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR253W / YLR253W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:6.58|P-value:1.49E-11 ID:SGTC_165|Compound:k038-0023|FD-Score:3.25|P-value:5.38E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.99|P-value:2.79E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.18|P-value:1.25E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.65|P-value:9.93E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.25|P-value:5.21E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.56|P-value:1.66E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.08|P-value:1.44E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:3.50|P-value:2.07E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.38|P-value:3.31E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.75|P-value:8.14E-7 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.99|P-value:2.87E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.65|P-value:1.38E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.14|P-value:7.74E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.72|P-value:7.50E-5 ID:SGTC_1907|Compound:st060210|FD-Score:-3.10|P-value:7.90E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.41|P-value:3.00E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.11|P-value:8.54E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.23|P-value:5.69E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.20|P-value:5.53E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.87|P-value:4.78E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.79|P-value:6.67E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.78|P-value:6.82E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.17|P-value:1.08E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.08|P-value:8.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.10|P-value:8.84E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.97|P-value:2.58E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.31|P-value:4.18E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.12|P-value:8.22E-4 ID:SGTC_2907|Compound:7721985|FD-Score:5.10|P-value:1.28E-7 ID:SGTC_2916|Compound:7875993|FD-Score:3.99|P-value:2.89E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.86|P-value:4.53E-7 ID:SGTC_2942|Compound:9052777|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.59|P-value:1.47E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.19|P-value:6.56E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.09|P-value:9.33E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.77|P-value:6.30E-5 ID:SGTC_3220|Compound:9131269|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:6.58|P-value:1.49E-11 ID:SGTC_165|Compound:k038-0023|FD-Score:3.25|P-value:5.38E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.99|P-value:2.79E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.18|P-value:1.25E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.65|P-value:9.93E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.25|P-value:5.21E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.56|P-value:1.66E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.08|P-value:1.44E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:3.50|P-value:2.07E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.38|P-value:3.31E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.75|P-value:8.14E-7 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.99|P-value:2.87E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.65|P-value:1.38E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.14|P-value:7.74E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.72|P-value:7.50E-5 ID:SGTC_1907|Compound:st060210|FD-Score:-3.10|P-value:7.90E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.41|P-value:3.00E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.11|P-value:8.54E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.23|P-value:5.69E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.20|P-value:5.53E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.87|P-value:4.78E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.79|P-value:6.67E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.78|P-value:6.82E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.17|P-value:1.08E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.08|P-value:8.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.10|P-value:8.84E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.97|P-value:2.58E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.31|P-value:4.18E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.12|P-value:8.22E-4 ID:SGTC_2907|Compound:7721985|FD-Score:5.10|P-value:1.28E-7 ID:SGTC_2916|Compound:7875993|FD-Score:3.99|P-value:2.89E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.86|P-value:4.53E-7 ID:SGTC_2942|Compound:9052777|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.59|P-value:1.47E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.19|P-value:6.56E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.09|P-value:9.33E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.77|P-value:6.30E-5 ID:SGTC_3220|Compound:9131269|FD-Score:3.13|P-value:7.96E-4

Top fitness defect scores for YLR253W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 6.58 471.9 µM 1.49E-11 ubiquinone biosynthesis & proteasome 79 2.37E-11
2 SGTC_2907 7721985 5.10 69.9 µM 1.28E-7 5 1.66E-7
3 SGTC_635 k038-0028 5.08 24.7 µM 1.44E-7 ubiquinone biosynthesis & proteasome 27 1.87E-7
4 SGTC_2771 fluoxetine 4.97 41.0 µM 2.58E-7 7 3.30E-7
5 SGTC_2924 9010168 4.86 62.8 µM 4.53E-7 cell wall signaling 18 5.73E-7
6 SGTC_1013 4112-3890 4.75 241.0 µM 8.14E-7 TSC3-RPN4 19 1.02E-6
7 SGTC_1427 4048-4900 4.65 550.0 nM 1.38E-6 18 1.70E-6
8 SGTC_367 0335-0881 4.18 7.1 µM 1.25E-5 ubiquinone biosynthesis & proteasome 68 1.48E-5
9 SGTC_294 k038-0071 3.99 157.0 µM 2.79E-5 ubiquinone biosynthesis & proteasome 63 3.24E-5
10 SGTC_1198 1612-1005 3.99 86.7 µM 2.87E-5 12 3.32E-5
11 SGTC_2916 7875993 3.99 68.8 µM 2.89E-5 27 3.34E-5
12 SGTC_2417 cerulenin 3.87 830.0 nM 4.78E-5 34 5.47E-5
13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.79 63.6 µM 6.67E-5 50 7.59E-5
14 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.78 92.6 µM 6.82E-5 31 7.76E-5
15 SGTC_3019 9081971 3.67 49.5 µM 1.06E-4 23 1.19E-4
16 SGTC_340 k038-0059 3.60 454.0 µM 1.42E-4 ubiquinone biosynthesis & proteasome 56 1.59E-4
17 SGTC_3087 9117406 3.59 49.5 µM 1.47E-4 29 1.64E-4
18 SGTC_507 nimesulide 3.56 162.0 µM 1.66E-4 26 1.85E-4
19 SGTC_794 k038-0031 3.50 316.0 µM 2.07E-4 ubiquinone biosynthesis & proteasome 128 2.31E-4
20 SGTC_2119 5528445 3.41 120.6 µM 3.00E-4 41 3.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 3.87E-51 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.234 6.60E-43 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.228 7.47E-41 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.224 1.41E-39 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.222 7.09E-39 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.221 2.25E-38 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.214 3.23E-36 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.201 9.89E-32 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.198 6.24E-31 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.183 1.04E-26 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.178 3.26E-25 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.173 5.40E-24 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.173 6.47E-24 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.171 1.63E-23 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.169 5.17E-23 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p