YLR255C_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR255C / YLR255C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.07|P-value:2.77E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.10|P-value:8.16E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.44|P-value:3.28E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.40|P-value:2.75E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.57|P-value:2.93E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:4.28|P-value:1.10E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.04|P-value:2.75E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.29|P-value:7.00E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:-4.41|P-value:4.10E-6 ID:SGTC_406|Compound:estrone|FD-Score:4.91|P-value:5.29E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.09|P-value:1.71E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-5.90|P-value:1.28E-9 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:5.49|P-value:2.48E-8 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.65|P-value:1.05E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.77|P-value:7.03E-7 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.07|P-value:8.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.94|P-value:4.76E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.17|P-value:6.34E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.25|P-value:6.62E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.36|P-value:3.17E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.36|P-value:4.42E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.76|P-value:9.82E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:4.31|P-value:9.69E-6 ID:SGTC_917|Compound:harmaline|FD-Score:6.31|P-value:1.65E-10 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.53|P-value:1.69E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.64|P-value:2.02E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.32|P-value:5.18E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.60|P-value:1.28E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.31|P-value:9.53E-6 ID:SGTC_1802|Compound:st050112|FD-Score:-3.22|P-value:5.34E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.76|P-value:6.99E-5 ID:SGTC_1868|Compound:st057644|FD-Score:-3.69|P-value:9.05E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.57|P-value:2.04E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.30|P-value:5.49E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.25|P-value:6.65E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-5.21|P-value:6.88E-8 ID:SGTC_2267|Compound:7931562|FD-Score:-4.98|P-value:2.37E-7 ID:SGTC_2268|Compound:7933382|FD-Score:-3.76|P-value:6.82E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.03|P-value:2.96E-7 ID:SGTC_2353|Compound:9059630|FD-Score:3.77|P-value:9.49E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.23|P-value:6.99E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.06|P-value:9.42E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.41|P-value:3.75E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.19|P-value:7.99E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.25|P-value:4.77E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.27|P-value:6.11E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-4.25|P-value:8.44E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.13|P-value:9.97E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.84|P-value:5.03E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.18|P-value:6.21E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.21|P-value:5.49E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.24|P-value:6.80E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.47|P-value:2.74E-8 ID:SGTC_3108|Compound:9121785|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.83|P-value:3.34E-9 ID:SGTC_6|Compound:0844-0013|FD-Score:4.07|P-value:2.77E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.10|P-value:8.16E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.44|P-value:3.28E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.40|P-value:2.75E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.57|P-value:2.93E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:4.28|P-value:1.10E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.04|P-value:2.75E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.29|P-value:7.00E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:-4.41|P-value:4.10E-6 ID:SGTC_406|Compound:estrone|FD-Score:4.91|P-value:5.29E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.09|P-value:1.71E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-5.90|P-value:1.28E-9 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:5.49|P-value:2.48E-8 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.65|P-value:1.05E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.77|P-value:7.03E-7 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.07|P-value:8.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.94|P-value:4.76E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.17|P-value:6.34E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.25|P-value:6.62E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.36|P-value:3.17E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.36|P-value:4.42E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.76|P-value:9.82E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:4.31|P-value:9.69E-6 ID:SGTC_917|Compound:harmaline|FD-Score:6.31|P-value:1.65E-10 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.53|P-value:1.69E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.64|P-value:2.02E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.32|P-value:5.18E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.60|P-value:1.28E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.31|P-value:9.53E-6 ID:SGTC_1802|Compound:st050112|FD-Score:-3.22|P-value:5.34E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.76|P-value:6.99E-5 ID:SGTC_1868|Compound:st057644|FD-Score:-3.69|P-value:9.05E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.57|P-value:2.04E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.30|P-value:5.49E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.25|P-value:6.65E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-5.21|P-value:6.88E-8 ID:SGTC_2267|Compound:7931562|FD-Score:-4.98|P-value:2.37E-7 ID:SGTC_2268|Compound:7933382|FD-Score:-3.76|P-value:6.82E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.03|P-value:2.96E-7 ID:SGTC_2353|Compound:9059630|FD-Score:3.77|P-value:9.49E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.23|P-value:6.99E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.06|P-value:9.42E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.41|P-value:3.75E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.19|P-value:7.99E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.25|P-value:4.77E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.27|P-value:6.11E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-4.25|P-value:8.44E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.13|P-value:9.97E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.84|P-value:5.03E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.18|P-value:6.21E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.21|P-value:5.49E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.24|P-value:6.80E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.47|P-value:2.74E-8 ID:SGTC_3108|Compound:9121785|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.83|P-value:3.34E-9

Top fitness defect scores for YLR255C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_917 harmaline 6.31 728.1 nM 1.65E-10 ergosterol biosynthesis 4 1.35E-10
2 SGTC_3152 9099253 5.83 49.5 µM 3.34E-9 NEO1-PIK1 59 2.76E-9
3 SGTC_410 α-linolenic acid 5.49 100.0 µM 2.48E-8 excess fatty acid 15 2.06E-8
4 SGTC_3101 9120531 5.47 49.5 µM 2.74E-8 7 2.29E-8
5 SGTC_2413 inermin 5.41 26.1 µM 3.75E-8 24 3.13E-8
6 SGTC_363 0455-0021 5.04 3.1 µM 2.75E-7 azole & statin 40 2.31E-7
7 SGTC_2342 7990637 5.03 118.9 µM 2.96E-7 RNA processing & uracil transport 13 2.49E-7
8 SGTC_406 estrone 4.91 100.0 µM 5.29E-7 4 4.46E-7
9 SGTC_1313 1220-0047 4.64 237.0 µM 2.02E-6 23 1.71E-6
10 SGTC_312 4092-0653 4.57 6.8 µM 2.93E-6 ergosterol depletion effects on membrane 67 2.48E-6
11 SGTC_1568 digitonin 4.31 820.0 nM 9.53E-6 sphingolipid biosynthesis & PDR1 25 8.14E-6
12 SGTC_909 3448-9333 4.31 149.0 µM 9.69E-6 12 8.28E-6
13 SGTC_327 1273-0057 4.28 4.0 µM 1.10E-5 azole & statin 26 9.38E-6
14 SGTC_6 0844-0013 4.07 19.8 µM 2.77E-5 78 2.38E-5
15 SGTC_513 4245-1575 3.94 41.7 µM 4.76E-5 unfolded protein response 118 4.11E-5
16 SGTC_2353 9059630 3.77 146.7 µM 9.49E-5 21 8.22E-5
17 SGTC_863 0466-0191 3.76 129.0 µM 9.82E-5 cell wall 78 8.50E-5
18 SGTC_2321 7390090 3.64 138.8 µM 1.55E-4 37 1.34E-4
19 SGTC_1259 0671-0132 3.63 43.0 µM 1.62E-4 34 1.41E-4
20 SGTC_1908 st060353 3.57 56.5 µM 2.04E-4 RPP1 & pyrimidine depletion 56 1.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 7.58E-30 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.162 3.22E-21 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.151 1.25E-18 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.136 3.24E-15 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.134 8.06E-15 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.128 1.29E-13 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.126 2.86E-13 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.123 7.87E-13 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.122 1.06E-12 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.115 1.98E-11 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.115 2.82E-11 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.112 7.20E-11 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.110 1.44E-10 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.110 2.00E-10 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.107 4.55E-10 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation