YLR258W / GSY2

Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR258W / GSY2

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:4.22|P-value:3.05E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.78|P-value:2.87E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:4.48|P-value:1.07E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.31|P-value:8.00E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.26|P-value:9.20E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.44|P-value:8.11E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.41|P-value:5.63E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.38|P-value:6.28E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.32|P-value:7.71E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.41|P-value:5.63E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.93|P-value:1.02E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:3.64|P-value:2.66E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.24|P-value:9.93E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.75|P-value:1.75E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.19|P-value:3.41E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.93|P-value:1.54E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.67|P-value:2.34E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.79|P-value:2.48E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:6.04|P-value:5.67E-9 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.49|P-value:4.31E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.52|P-value:3.89E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.62|P-value:5.91E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.51|P-value:4.14E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.58|P-value:3.24E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.50|P-value:4.19E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.49|P-value:4.37E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.76|P-value:2.78E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.79|P-value:1.54E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.31|P-value:3.59E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.59|P-value:6.57E-6 ID:SGTC_2179|Compound:6298986|FD-Score:3.54|P-value:3.71E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.12|P-value:4.50E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.74|P-value:1.86E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.74|P-value:1.85E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-3.48|P-value:7.02E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.97|P-value:7.92E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-6.36|P-value:2.04E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.50|P-value:6.67E-4 ID:SGTC_2971|Compound:9092186|FD-Score:9.12|P-value:4.28E-18 ID:SGTC_3132|Compound:9126706|FD-Score:3.53|P-value:3.84E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.59|P-value:5.03E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.32|P-value:7.54E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.72|P-value:3.21E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.91|P-value:1.63E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:4.22|P-value:3.05E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.78|P-value:2.87E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:4.48|P-value:1.07E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.31|P-value:8.00E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.26|P-value:9.20E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.44|P-value:8.11E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.41|P-value:5.63E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.38|P-value:6.28E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.32|P-value:7.71E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.41|P-value:5.63E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.93|P-value:1.02E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:3.64|P-value:2.66E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.24|P-value:9.93E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.75|P-value:1.75E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.19|P-value:3.41E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.93|P-value:1.54E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.67|P-value:2.34E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.79|P-value:2.48E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:6.04|P-value:5.67E-9 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.49|P-value:4.31E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.52|P-value:3.89E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.62|P-value:5.91E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.51|P-value:4.14E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.58|P-value:3.24E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.50|P-value:4.19E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.49|P-value:4.37E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.76|P-value:2.78E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.79|P-value:1.54E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.31|P-value:3.59E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.59|P-value:6.57E-6 ID:SGTC_2179|Compound:6298986|FD-Score:3.54|P-value:3.71E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.12|P-value:4.50E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.74|P-value:1.86E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.74|P-value:1.85E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-3.48|P-value:7.02E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.97|P-value:7.92E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-6.36|P-value:2.04E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.50|P-value:6.67E-4 ID:SGTC_2971|Compound:9092186|FD-Score:9.12|P-value:4.28E-18 ID:SGTC_3132|Compound:9126706|FD-Score:3.53|P-value:3.84E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.59|P-value:5.03E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.32|P-value:7.54E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.72|P-value:3.21E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.91|P-value:1.63E-4

Top fitness defect scores for YLR258W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2971 9092186 9.12 9.9 µM 4.28E-18 ergosterol biosynthesis 1 3.78E-20
2 SGTC_1249 0481-0015 6.04 10.2 µM 5.67E-9 8 7.87E-10
3 SGTC_785 1270-0111 5.93 65.3 µM 1.02E-8 2 1.52E-9
4 SGTC_16 erodoxin 4.78 22.8 µM 2.87E-6 unfolded protein response 41 8.68E-7
5 SGTC_1471 k673-0312 4.62 37.0 µM 5.91E-6 RNA processing & uracil transport 7 1.96E-6
6 SGTC_2067 5224629 4.59 34.1 µM 6.57E-6 12 2.20E-6
7 SGTC_24 0417-1663 4.48 219.0 µM 1.07E-5 13 3.80E-6
8 SGTC_12 0849-0099 4.22 9.3 µM 3.05E-5 19 1.23E-5
9 SGTC_913 3487-1245 4.19 167.0 µM 3.41E-5 21 1.39E-5
10 SGTC_2329 6138490 4.12 200.0 µM 4.50E-5 26 1.90E-5
11 SGTC_2712 st079126 3.97 47.7 µM 7.92E-5 14 3.58E-5
12 SGTC_1105 epirubicin 3.88 18.1 µM 1.11E-4 anthracycline transcription coupled DNA repair 21 5.20E-5
13 SGTC_806 3966-4455 3.84 5.9 µM 1.28E-4 23 6.15E-5
14 SGTC_1925 st057770 3.79 10.1 µM 1.54E-4 TSC3-RPN4 20 7.50E-5
15 SGTC_870 0573-2213 3.75 57.6 µM 1.75E-4 ERG2 24 8.70E-5
16 SGTC_2573 2',4'-dihydroxychalcone 3.74 15.0 µM 1.85E-4 61 9.22E-5
17 SGTC_2474 5321570 3.74 43.3 µM 1.86E-4 20 9.27E-5
18 SGTC_1171 0368-0077 3.67 21.4 µM 2.34E-4 27 1.20E-4
19 SGTC_1467 k284-1082 3.65 293.0 µM 2.50E-4 25 1.29E-4
20 SGTC_788 1182-0090 3.64 188.0 µM 2.66E-4 endomembrane recycling 92 1.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.73E-19 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.100 6.39E-9 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.095 4.11E-8 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.084 1.14E-6 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.082 1.79E-6 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.081 2.99E-6 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.080 3.24E-6 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.080 3.62E-6 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.078 5.33E-6 YPL213W LEA1 hom Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein
0.074 1.57E-5 YCL056C PEX34 hom Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation
0.074 1.91E-5 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.074 1.99E-5 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.072 2.94E-5 YER137C_p YER137C_p hom Putative protein of unknown function
0.070 4.54E-5 YHL015W-A_p YHL015W-A_p hom Putative protein of unknown function
0.069 6.95E-5 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data