YLR261C_d / VPS63

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR261C / VPS63

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:-5.15|P-value:1.50E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:13.10|P-value:9.79E-20 ID:SGTC_56|Compound:0957-0365|FD-Score:5.15|P-value:2.37E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.90|P-value:3.00E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.79|P-value:5.83E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.60|P-value:9.05E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:7.74|P-value:6.26E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:4.62|P-value:8.74E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-5.22|P-value:1.23E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-7.22|P-value:2.29E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.25|P-value:1.79E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.89|P-value:4.56E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.70|P-value:3.85E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:4.78|P-value:5.86E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.11|P-value:1.48E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:-4.64|P-value:5.58E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.48|P-value:8.13E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-5.01|P-value:2.17E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:5.74|P-value:4.66E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:4.89|P-value:4.48E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.73|P-value:6.67E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-7.29|P-value:1.74E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.46|P-value:6.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-5.61|P-value:4.19E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-5.41|P-value:7.30E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.92|P-value:4.16E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.72|P-value:6.88E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.83|P-value:5.21E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.40|P-value:1.20E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:8.93|P-value:5.03E-10 ID:SGTC_1313|Compound:1220-0047|FD-Score:7.21|P-value:4.37E-7 ID:SGTC_1325|Compound:1431-0015|FD-Score:5.40|P-value:1.21E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:5.37|P-value:1.33E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-4.59|P-value:6.24E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:7.11|P-value:6.05E-7 ID:SGTC_1496|Compound:4469-0713|FD-Score:7.41|P-value:2.15E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:8.75|P-value:1.10E-9 ID:SGTC_1547|Compound:harmine|FD-Score:-8.04|P-value:9.95E-9 ID:SGTC_1573|Compound:oleylamine|FD-Score:-8.53|P-value:1.32E-9 ID:SGTC_1638|Compound:st008370|FD-Score:-5.32|P-value:9.48E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-5.18|P-value:1.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.47|P-value:6.26E-5 ID:SGTC_1773|Compound:st048542|FD-Score:-7.05|P-value:4.24E-7 ID:SGTC_1781|Compound:st038725|FD-Score:-5.08|P-value:1.82E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.61|P-value:8.81E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-7.28|P-value:1.82E-7 ID:SGTC_1826|Compound:st055655|FD-Score:-5.28|P-value:1.06E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.89|P-value:2.98E-4 ID:SGTC_1979|Compound:st071809|FD-Score:5.49|P-value:9.37E-5 ID:SGTC_1980|Compound:st071811|FD-Score:5.91|P-value:2.90E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-4.88|P-value:3.06E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-8.34|P-value:3.01E-9 ID:SGTC_2006|Compound:4011487|FD-Score:-7.06|P-value:3.99E-7 ID:SGTC_2030|Compound:5175110|FD-Score:5.94|P-value:2.62E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-5.62|P-value:4.13E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.32|P-value:9.44E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-5.38|P-value:8.05E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-6.21|P-value:6.85E-6 ID:SGTC_2133|Compound:5320837|FD-Score:4.64|P-value:8.23E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.09|P-value:2.73E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-5.67|P-value:3.55E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-5.14|P-value:1.52E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-4.40|P-value:9.87E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.96|P-value:3.85E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.90|P-value:2.98E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.86|P-value:4.91E-4 ID:SGTC_2325|Compound:6158266|FD-Score:5.94|P-value:2.67E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-5.85|P-value:2.06E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-4.87|P-value:3.08E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.26|P-value:1.74E-4 ID:SGTC_2460|Compound:5552655|FD-Score:7.77|P-value:5.69E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:-6.14|P-value:8.50E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.10|P-value:2.67E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.59|P-value:6.21E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:6.45|P-value:5.53E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.72|P-value:6.93E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.58|P-value:7.48E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.41|P-value:9.51E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-5.64|P-value:3.89E-5 ID:SGTC_2851|Compound:9015922|FD-Score:5.75|P-value:4.59E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-4.71|P-value:4.62E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-6.98|P-value:5.39E-7 ID:SGTC_2991|Compound:9074669|FD-Score:-7.72|P-value:3.51E-8 ID:SGTC_2993|Compound:9054257|FD-Score:-4.54|P-value:6.97E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-7.12|P-value:3.28E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-12.70|P-value:6.85E-19 ID:SGTC_3143|Compound:9086658|FD-Score:-4.76|P-value:4.10E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.99|P-value:3.51E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-6.45|P-value:3.25E-6 ID:SGTC_3229|Compound:9132204|FD-Score:5.53|P-value:8.48E-5 ID:SGTC_3236|Compound:9132701|FD-Score:6.24|P-value:1.05E-5 ID:SGTC_3238|Compound:9133470|FD-Score:5.71|P-value:5.18E-5 ID:SGTC_3269|Compound:9137823|FD-Score:5.67|P-value:5.69E-5 ID:SGTC_3279|Compound:9140807|FD-Score:5.56|P-value:7.82E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-4.97|P-value:2.43E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:-5.15|P-value:1.50E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:13.10|P-value:9.79E-20 ID:SGTC_56|Compound:0957-0365|FD-Score:5.15|P-value:2.37E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.90|P-value:3.00E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.79|P-value:5.83E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.60|P-value:9.05E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:7.74|P-value:6.26E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:4.62|P-value:8.74E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-5.22|P-value:1.23E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-7.22|P-value:2.29E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.25|P-value:1.79E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.89|P-value:4.56E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.70|P-value:3.85E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:4.78|P-value:5.86E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.11|P-value:1.48E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:-4.64|P-value:5.58E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.48|P-value:8.13E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-5.01|P-value:2.17E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:5.74|P-value:4.66E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:4.89|P-value:4.48E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.73|P-value:6.67E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-7.29|P-value:1.74E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.46|P-value:6.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-5.61|P-value:4.19E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-5.41|P-value:7.30E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.92|P-value:4.16E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.72|P-value:6.88E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.83|P-value:5.21E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.40|P-value:1.20E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:8.93|P-value:5.03E-10 ID:SGTC_1313|Compound:1220-0047|FD-Score:7.21|P-value:4.37E-7 ID:SGTC_1325|Compound:1431-0015|FD-Score:5.40|P-value:1.21E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:5.37|P-value:1.33E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-4.59|P-value:6.24E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:7.11|P-value:6.05E-7 ID:SGTC_1496|Compound:4469-0713|FD-Score:7.41|P-value:2.15E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:8.75|P-value:1.10E-9 ID:SGTC_1547|Compound:harmine|FD-Score:-8.04|P-value:9.95E-9 ID:SGTC_1573|Compound:oleylamine|FD-Score:-8.53|P-value:1.32E-9 ID:SGTC_1638|Compound:st008370|FD-Score:-5.32|P-value:9.48E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-5.18|P-value:1.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.47|P-value:6.26E-5 ID:SGTC_1773|Compound:st048542|FD-Score:-7.05|P-value:4.24E-7 ID:SGTC_1781|Compound:st038725|FD-Score:-5.08|P-value:1.82E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.61|P-value:8.81E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-7.28|P-value:1.82E-7 ID:SGTC_1826|Compound:st055655|FD-Score:-5.28|P-value:1.06E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.89|P-value:2.98E-4 ID:SGTC_1979|Compound:st071809|FD-Score:5.49|P-value:9.37E-5 ID:SGTC_1980|Compound:st071811|FD-Score:5.91|P-value:2.90E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-4.88|P-value:3.06E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-8.34|P-value:3.01E-9 ID:SGTC_2006|Compound:4011487|FD-Score:-7.06|P-value:3.99E-7 ID:SGTC_2030|Compound:5175110|FD-Score:5.94|P-value:2.62E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-5.62|P-value:4.13E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.32|P-value:9.44E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-5.38|P-value:8.05E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-6.21|P-value:6.85E-6 ID:SGTC_2133|Compound:5320837|FD-Score:4.64|P-value:8.23E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.09|P-value:2.73E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-5.67|P-value:3.55E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-5.14|P-value:1.52E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-4.40|P-value:9.87E-4 ID:SGTC_2242|Compound:6630449|FD-Score:4.96|P-value:3.85E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.90|P-value:2.98E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.86|P-value:4.91E-4 ID:SGTC_2325|Compound:6158266|FD-Score:5.94|P-value:2.67E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-5.85|P-value:2.06E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-4.87|P-value:3.08E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.26|P-value:1.74E-4 ID:SGTC_2460|Compound:5552655|FD-Score:7.77|P-value:5.69E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:-6.14|P-value:8.50E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.10|P-value:2.67E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.59|P-value:6.21E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:6.45|P-value:5.53E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.72|P-value:6.93E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.58|P-value:7.48E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.41|P-value:9.51E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-5.64|P-value:3.89E-5 ID:SGTC_2851|Compound:9015922|FD-Score:5.75|P-value:4.59E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-4.71|P-value:4.62E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-6.98|P-value:5.39E-7 ID:SGTC_2991|Compound:9074669|FD-Score:-7.72|P-value:3.51E-8 ID:SGTC_2993|Compound:9054257|FD-Score:-4.54|P-value:6.97E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-7.12|P-value:3.28E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-12.70|P-value:6.85E-19 ID:SGTC_3143|Compound:9086658|FD-Score:-4.76|P-value:4.10E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.99|P-value:3.51E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-6.45|P-value:3.25E-6 ID:SGTC_3229|Compound:9132204|FD-Score:5.53|P-value:8.48E-5 ID:SGTC_3236|Compound:9132701|FD-Score:6.24|P-value:1.05E-5 ID:SGTC_3238|Compound:9133470|FD-Score:5.71|P-value:5.18E-5 ID:SGTC_3269|Compound:9137823|FD-Score:5.67|P-value:5.69E-5 ID:SGTC_3279|Compound:9140807|FD-Score:5.56|P-value:7.82E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-4.97|P-value:2.43E-4

Top fitness defect scores for YLR261C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_22 0964-0034 13.10 14.5 µM 9.79E-20 unfolded protein response 5 9.57E-40
2 SGTC_1184 1269-1718 8.93 139.0 µM 5.03E-10 1 2.11E-19
3 SGTC_1510 1123-0200 8.75 71.5 µM 1.10E-9 6 1.08E-18
4 SGTC_528 3492-0019 8.11 172.0 µM 1.48E-8 calcium & mitochondrial duress 69 2.46E-16
5 SGTC_2460 5552655 7.77 174.2 µM 5.69E-8 amide catabolism 6 4.08E-15
6 SGTC_133 0724-0033 7.74 378.9 µM 6.26E-8 3 4.99E-15
7 SGTC_1496 4469-0713 7.41 57.4 µM 2.15E-7 6 6.55E-14
8 SGTC_1313 1220-0047 7.21 237.0 µM 4.37E-7 10 2.86E-13
9 SGTC_1470 k295-0292 7.11 231.0 µM 6.05E-7 3 5.62E-13
10 SGTC_2689 tacrolimus 6.45 100.0 µM 5.53E-6 8 5.58E-11
11 SGTC_3236 9132701 6.24 49.5 µM 1.05E-5 TSC3-RPN4 3 2.13E-10
12 SGTC_2030 5175110 5.94 200.0 µM 2.62E-5 Golgi 4 1.40E-9
13 SGTC_2325 6158266 5.94 200.0 µM 2.67E-5 4 1.46E-9
14 SGTC_1980 st071811 5.91 45.7 µM 2.90E-5 RPP1 & pyrimidine depletion 2 1.73E-9
15 SGTC_2290 7904846 5.90 200.0 µM 2.98E-5 4 1.83E-9
16 SGTC_91 0417-1751 5.90 58.4 µM 3.00E-5 Golgi 16 1.86E-9
17 SGTC_2851 9015922 5.75 71.4 µM 4.59E-5 9 4.49E-9
18 SGTC_643 k048-0106 5.74 28.4 µM 4.66E-5 RSC & ERG11 2 4.64E-9
19 SGTC_3238 9133470 5.71 49.5 µM 5.18E-5 3 5.77E-9
20 SGTC_3269 9137823 5.67 49.5 µM 5.69E-5 60S ribosome export 2 6.99E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 3.28E-200 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.445 5.43E-162 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.441 2.82E-159 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.345 1.30E-94 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.304 1.90E-72 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.303 8.42E-72 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.289 1.54E-65 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.276 1.54E-59 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.271 3.03E-57 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.270 4.47E-57 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.203 2.02E-32 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.200 1.41E-31 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.178 2.91E-25 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.176 8.98E-25 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
0.174 2.87E-24 YGL223C COG1 hom Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments